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anti-Human PDCD6IP Antikörper:
anti-Mouse (Murine) PDCD6IP Antikörper:
anti-Rat (Rattus) PDCD6IP Antikörper:
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Human Polyclonal PDCD6IP Primary Antibody für WB - ABIN1881644
Inuzuka, Suzuki, Kawasaki, Shibata, Wakatsuki, Maki: Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition. in BMC structural biology 2010
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Human Polyclonal PDCD6IP Primary Antibody für IF, IHC - ABIN347079
Mahul-Mellier, Hemming, Blot, Fraboulet, Sadoul: Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
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Human Monoclonal PDCD6IP Primary Antibody für IF, IHC (p) - ABIN2477348
Bechmann, Weiss: Regulation of the proton/electron stoichiometry of mitochondrial ubiquinol:cytochrome c reductase by the membrane potential. in European journal of biochemistry / FEBS 1991
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Mouse (Murine) Monoclonal PDCD6IP Primary Antibody für IF, WB - ABIN968616
Chen, Borinstein, Gillis, Sykes, Bogler: The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes. in The Journal of biological chemistry 2000
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Mouse (Murine) Monoclonal PDCD6IP Primary Antibody für IF, WB - ABIN968617
Vito, Pellegrini, Guiet, DAdamio: Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction. in The Journal of biological chemistry 1999
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Human Monoclonal PDCD6IP Primary Antibody für ICC, IF - ABIN260230
Haga, Yan, Takahashi, Matsuda, Patel: Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice. in Stem cells translational medicine 2017
Human Polyclonal PDCD6IP Primary Antibody für IF, WB - ABIN523392
Kowal, Arras, Colombo, Jouve, Morath, Primdal-Bengtson, Dingli, Loew, Tkach, Théry: Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. in Proceedings of the National Academy of Sciences of the United States of America 2016
We conclude that ALIX and ESCRT-III coordinately control abscission in Drosophila fGSCs and that their complex formation is required for accurate abscission timing in GSCs in vivo.
farnesylation of K-Ras (zeige HRAS Antikörper) was required for its packaging within extracellular nanovesicles, yet expressing a K-Ras (zeige HRAS Antikörper) farnesylation mutant did not decrease the number of nanovesicles or the amount of Alix protein released per cell.
DAB2IP (zeige DAB2IP Antikörper) loss reprograms intracellular signal transduction and anti-apoptotic gene expression, which potentiates prostate cancer cell survival from androgen deprivation therapy-induced cell death.
Germ cell-specific or Sertoli cell-specific deletion of Aip1 gene each led to significant defects in germ cell migration after postnatal day 4 or 5, accompanied by elevated levels of actin filaments (F-actin) in the affected cells.
Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments.
results suggest that Dab2IP plays an important role in the migration and positioning of a subpopulation of later-born (layers II-IV) neurons, likely through the regulation of Rap1 and integrin signaling.
Our data reveal that AIP1, by inhibiting VEGFR2 (zeige KDR Antikörper)-dependent signaling in tumor niche, suppresses tumor EMT (zeige ITK Antikörper) switch, tumor angiogenesis, and tumor premetastatic niche formation to limit tumor growth and metastasis.
AIP1 was elevated in the brain of AD Tg2576 mice. Abeta1-42 treatment induced the interaction of AIP1 and ASK1 (zeige MAP3K5 Antikörper), which led to dissociation of ASK1 (zeige MAP3K5 Antikörper) and 14-3-3 (zeige YWHAQ Antikörper).
site-specific methylation of mDab2ip gene during cerebellar development may play a role in inclusion of exon 5, resulting in a Dab2ip (zeige DAB2IP Antikörper) transcript variant that encodes a full pleckstrin (zeige PLEK Antikörper) homology (PH) domain.
ATG12 (zeige ATG12 Antikörper)-ATG3 (zeige ATG3 Antikörper) interacts with Alix to promote basal autophagic flux and late endosome function.
Study showed that DAB2IP (zeige DAB2IP Antikörper) can be functionally inactivated by physical interaction with mutant p53 (zeige TP53 Antikörper) proteins with implications for the response of cancer cells to inflammatory cytokines.
These findings establish that Xp95/Alix is phosphorylated within the proline-rich domain during M-phase induction, and indicate that the phosphorylation may both positively and negatively modulate their interaction with partner proteins.
MRTF-A (zeige MKL1 Antikörper)-miR (zeige MLXIP Antikörper)-206-WDR1 (zeige WDR1 Antikörper) form feedback loop to regulate breast cancer cell migration.
Alix plays an important role in the proliferation of glioma cells and overexpression in gliomas predicts poor survival.
homozygous missense L153F/L293F mutation in the actin regulatory gene WDR1 (zeige WDR1 Antikörper) causes a new autoinflammatory disease in humans, with periodic fevers, immunodeficiency, and intermittent thrombocytopenia (PFIT).
These data suggest that WDR1 (zeige WDR1 Antikörper) plays an important role in suppressing platelet activity, where it alters the actin cytoskeleton dynamics, and downregulation of WDR1 (zeige WDR1 Antikörper) may contribute to the platelet-mediated pathogenesis of cardiovascular disease.
Mutations in WDR1 (zeige WDR1 Antikörper) affect neutrophil morphology, motility, and function, causing a novel primary immunodeficiency
ALIX regulates P2Y1 (zeige P2RY1 Antikörper) degradation.
Identify positive correlations between WDR1 (zeige WDR1 Antikörper) and CLNK (zeige CLNK Antikörper) gene polymorphisms in Chinese-Tibetan gout populations.
These findings indicate that Alix binds to Ago2 (zeige EIF2C2 Antikörper) and miRNAs, suggesting that it plays a key role in miRNA enrichment during extracellular vesicles biogenesis.
The authors find that HIV-1 nucleocapsid mimics the PDZ (zeige INADL Antikörper) domains of syntenin (zeige SDCBP Antikörper), a membrane-binding adaptor involved in cell-to-cell contact/communication, to capture the Bro1 (zeige HMGCR Antikörper) domain of ALIX, which is an ESCRTs recruiting cellular adaptor.
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
ALG-2 interacting protein 1
, ALG-2-interacting protein X
, PDCD6-interacting protein
, apoptosis-linked gene 2-interacting protein X
, dopamine receptor interacting protein 4
, programmed cell death 6-interacting protein
, ALG-2-interacting protein 1
, Alg2-interacting protein 1
, Alg2-interacting protein X
, E2f1-inducible protein
, ALG-2 interacting protein X
, programmed cell death 6 interacting protein
, Programmed cell death 6 interacting protein
, putative signal tranduction protein Xp95
, signal transduction protein Xp95