p53 Proteine (TP53)

Bezeichnung:
Tumor Protein P53 Proteine (TP53)
Auf www.antikoerper-online.de finden Sie aktuell 84 Tumor Protein P53 (TP53) Proteine von 17 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen p53 Antikörper (2452) und p53 Kits (143) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 2844 p53 Produkte verfügbar.
Synonyme:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
alle Proteine anzeigen Gen GeneID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
Ratte TP53 TP53 24842 P10361

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Am meisten referenzierte p53 Proteine

  1. Cynomolgus p53 Protein expressed in Escherichia coli (E. coli) - ABIN2009672 : Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999 (PubMed)
    Zeige alle 4 Referenzen für 2009672

  2. Human p53 Protein expressed in Wheat germ - ABIN1323380 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)
    Zeige alle 3 Referenzen für 1323380

  3. Human p53 Protein expressed in Escherichia coli (E. coli) - ABIN1046804 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)
    Zeige alle 3 Referenzen für 1046804

  4. Human p53 Protein expressed in HEK-293 Cells - ABIN2734068 : Li, Xia, Su, Qin, Chen, Li, Dong, Ding, Li, Huang, Ge, Hou, Wang, Sun, Bai, Shen, Fang, Liu, Zhang, Zhang, Zhang, Shao: Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse. in Scientific reports 2016 (PubMed)
    Zeige alle 2 Referenzen für 2734068

Weitere Proteine zu p53 Interaktionspartnern

Mouse (Murine) Tumor Protein P53 (TP53) Interaktionspartner

  1. Key features of genome recognition by p53 and unprecedented insight into the pathways associated with p53 reactivation and tumour regression, paving the way for their therapeutic application.

  2. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53/PCNA (zeige PCNA Proteine)- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.

  3. The TP53 knockout shifted the phenotypes of A549 cells induced by ALKBH3 (zeige ALKBH3 Proteine) knockdown from cell cycle arrest to apoptosis induction, suggesting that the TP53 gene status is a critical determinant of the phenotypes induced by ALKBH3 (zeige ALKBH3 Proteine) knockdown in NSCLC cells.

  4. Our study demonstrates that unlike conventional tumoricidal therapies, which rely on effective p53 targeting in each tumor cell and often associate with systemic toxicity, this immune-based strategy requires only limited local p53 activation to alter the immune landscape of TME and subsequently amplify immune response to systemic antitumor immunity

  5. median survival of KPIC mice was longer than that of LSL-KrasG12D; Ink4flox/flox; Ptf1/p48 (zeige PTF1A Proteine)-Cre mice (KIC) (89 vs 62 days) and shorter than that of KRAS (KrasG12D), TP53 (Trp53R172H/+) and Ptf1/p48 (zeige PTF1A Proteine)-Cre (KPC) mice

  6. Combined deletion of Vhl (zeige VHL Proteine), Trp53 and Rb1 (zeige RB1 Proteine) specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (zeige MOK Proteine).

  7. Data show that Emu-Myc (zeige MYC Proteine) mice lacking both p21 and PUMA (zeige BBC3 Proteine) developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC Proteine);p53(+/-)mice.

  8. The loss of p53 function is a requirement for the formation of giant spermatogonia (GSG) whereas DNA damage acts as a promoting trigger. The formation of GSG does not translate to higher efficacy of testicular tumorigenesis arising from mutant p53 cells, which might be due to the presence of delayed-onset of p53-independent apoptosis.

  9. p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (zeige ROCK2 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 Proteine) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 loss and novel NF-kappaB (zeige NFKB1 Proteine) expression

  10. TP53 mutation is associated with Triple-Negative Breast Cancer.

Human Tumor Protein P53 (TP53) Interaktionspartner

  1. Data establish the DLX3 (zeige DLX3 Proteine)-p53 interplay as a major regulatory axis in epidermal differentiation and suggest that DLX3 (zeige DLX3 Proteine) is a modulator of skin carcinogenesis.

  2. Data show that Prima-1 (zeige PRIMA1 Proteine) kills hypoxic wt p53 KRAS-mutant cells resistant to 3-bromopyruvate (3-BrPA), partly by decreasing GLUT-1 (zeige SLC2A1 Proteine) expression.

  3. Results indicate that the induction of long non-coding RNA NEAT1 expression contributes to the tumor-suppressor function of p53 and suggest that p53 and NEAT1 constitute a transcriptional network contributing to various biological functions and tumor suppression.

  4. HULC activates p53-p21 (zeige CDKN1A Proteine) pathway and promotes nasopharyngeal carcinoma cell growth.

  5. Mutations in TP53 and STK11 (zeige STK11 Proteine) also impacted tumor biology regardless of KRAS status, with TP53 strongly associated with enhanced proliferation and STK11 (zeige STK11 Proteine) with suppression of immune surveillance.

  6. Sp100A exhibits tumor-suppressive activity, not only by stabilizing p53 transactivation but also by depressing E1A (zeige BCKDHA Proteine)/E1B (zeige BCKDHB Proteine)-55K-mediated transformation.

  7. Here we present, as far as we are aware, the first case of metastatic microcystic adnexal carcinoma with DNA sequencing results indicating a mutation in TP53 and chromosomal losses in cyclin dependent kinase inhibitor 2A (CDKN2A) and cyclin dependent kinase inhibitor 2B (CDKN2B (zeige CDKN2B Proteine)).

  8. This case contradicts previous reports of p53 and BRAF (zeige BRAF Proteine) mutations portending worsened tumor behavior and prognosis and demonstrates that further studies are needed to delineate the role of genetic characterization in the biologic understanding and management of gangliogliomas.

  9. This work highlights the importance of the p53-miR-191-SOX4 axis in the regulation of apoptosis and doxorubicin resistance in breast cancer cell lines (MCF7 and ZR-75)

  10. Results indicate that it is possible to detect mutated p53 genes with the circulating DNA (cirDNA) and that this could be used as a biomarker of tumor recurrence during the clinical evolution of the transplanted patients.

Pig (Porcine) Tumor Protein P53 (TP53) Interaktionspartner

  1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

  2. SIRT1 (zeige SIRT1 Proteine), p53 and NF-kappaB (zeige NFKB1 Proteine) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  4. Data indicate that higher hepatic glucocorticoid receptor (GR (zeige NR3C1 Proteine)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (zeige SP1 Proteine)).

  5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (zeige MAPK14 Proteine) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  6. role of transcription factor p53 and the metabolic hormone leptin (zeige LEP Proteine), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (zeige BCL2 Proteine) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  9. Suppressive effect of FSH (zeige BRD2 Proteine) and LH on p53 expression and caspase-3 (zeige CASP3 Proteine) activity with parallel increase in bcl-2 (zeige BCL2 Proteine) expression and increased P production was observed.

  10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) Interaktionspartner

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (zeige MAPK14 Proteine) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (zeige MAPK14 Proteine) plays a role by way of stimulating NF-kappaB (zeige NFKB1 Proteine), p53 and caspase-3 (zeige CASP3 Proteine) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (zeige BCL2 Proteine) proteins.

  4. Chronically activated, monomeric PDGFRA (zeige PDGFRA Proteine) induced prolonged activation of Akt (zeige AKT1 Proteine) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) Interaktionspartner

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (zeige CASP3 Proteine), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) Interaktionspartner

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Proteine) and DNMT3A (zeige DNMT3A Proteine) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (zeige AKT1 Proteine) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) Interaktionspartner

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) Interaktionspartner

  1. Expression of p53 and Ki67 (zeige MKI67 Proteine) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) Interaktionspartner

  1. C/ebpalpha (zeige CEBPA Proteine) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (zeige KLF8 Proteine), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (zeige MDM2 Proteine) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) Interaktionspartner

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Protein Überblick

Protein Überblick

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758)
  • tumor protein p53 (TP53)
  • tumor supressor p53 (tp53)
  • p53 tumor suppressor (P53)
  • transformation related protein 53 (Trp53)
  • transformation related protein 53, pseudogene (Trp53-ps)
  • trichoplein, keratin filament binding (TCHP)
  • tumor protein p53 (Tp53)
  • tumor protein p53 (tp53)
  • Wistar clone pR53P1 p53 pseudogene (p53-ps)
  • bbl Protein
  • BCC7 Protein
  • bfy Protein
  • bhy Protein
  • brp53 Protein
  • drp53 Protein
  • etID22686.5 Protein
  • fb40d06 Protein
  • LFS1 Protein
  • p44 Protein
  • P53 Protein
  • Tp53 Protein
  • TpMs Protein
  • Trp53 Protein
  • wu:fb40d06 Protein
  • Xp53 Protein
  • zgc:111919 Protein

Bezeichner auf Proteinebene für Tumor Protein P53 Proteine (TP53)

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPEZIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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