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Human MDM2 ELISA Kit für Sandwich ELISA - ABIN422415
Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for osteosarcoma susceptibility in different populations [review and meta-analysis]
The MDM2 T/T genotype was predictive of poorer survival in a Japanese population of lung adenocarcinoma patients.
Blocking the MDM2 protein-XIAP (zeige XIAP ELISA Kits) mRNA interaction reduces MDM2 and XIAP (zeige XIAP ELISA Kits) levels and activates p53 (zeige TP53 ELISA Kits).
Patients with alterations in TP53 (zeige TP53 ELISA Kits) or MDM2 had a reduced progression-free survival, and TP53 (zeige TP53 ELISA Kits)/MDM2 alterations were an independent predictor of disease progression after cisplatin-based chemotherapy. TP53 (zeige TP53 ELISA Kits) alterations were identified in 72% of patients with primary mediastinal nonseminoma, which may explain their inferior outcomes.
our findings indicate the functional role of HBx in regulating the stem-like properties of OV6(+) CSCs in HCC (zeige FAM126A ELISA Kits) through the MDM2/CXCL12 (zeige CXCL12 ELISA Kits)/CXCR4 (zeige CXCR4 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling axis, and identify HBx, MDM2, CXCR4 (zeige CXCR4 ELISA Kits) and OV6 as a novel prognostic pathway and potential therapeutic targets for patients with HBV-related HCC (zeige FAM126A ELISA Kits) patients
This study suggests that MDM2 activates Smad (zeige SMAD1 ELISA Kits) pathway to promote EMT (zeige ITK ELISA Kits) in ovarian cancer metastasis.
The MDM2 SNP309 in retinal pigment epithelial cells enhances their potential of proliferative vitreoretinopathy pathogenesis.
High MDM2 expression is associated with acute myeloid leukemia (zeige BCL11A ELISA Kits).
mutant Mdm2 was unable to rescue a p53 (zeige TP53 ELISA Kits)-induced apoptotic phenotype.
High MDM2 expression is associated with Sjogren's syndrome.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (zeige TP53 ELISA Kits)-dependent apoptosis of Theileria parva (zeige PARVA ELISA Kits)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (zeige PARVA ELISA Kits), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (zeige PARVA ELISA Kits)-infected lymphocytes
Data indicate that knockdown of the Mdm2 and Mdm4 (zeige MDM4 ELISA Kits) caused dramatic accumulation of mutant p53 protein (zeige TP53 ELISA Kits).
Together with p53 (zeige TP53 ELISA Kits), provides an experimental model for characterizing drugs and genes that affect p53 (zeige TP53 ELISA Kits) signaling.
Data show that liver-specific expression of p53 (zeige TP53 ELISA Kits)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the existence of an unusual functional interplay between STATs and CREB (zeige CREB1 ELISA Kits) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (zeige TP53 ELISA Kits). Moreover, results suggest that p73 (zeige ARHGAP24 ELISA Kits) compensates for loss of p53 (zeige TP53 ELISA Kits).
In Fmr1 (zeige FMR1 ELISA Kits) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (zeige MEF2C ELISA Kits) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (zeige TSFM ELISA Kits) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (zeige FMR1 ELISA Kits) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (zeige DLG4 ELISA Kits) ubiquitination, degradation and synapse elimination in Fmr1 (zeige FMR1 ELISA Kits) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (zeige TP53 ELISA Kits) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (zeige TP53 ELISA Kits)-independent pathway dependant on Notch1 (zeige NOTCH1 ELISA Kits) ubiquitination and proteasome degradation.
These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (zeige TP53 ELISA Kits)/Mdm2-Mdm4 (zeige MDM4 ELISA Kits) via a RING domain-mediated biochemical mechanism.
both MDM2 and MDMX (zeige MDM4 ELISA Kits) deletion-caused pancreatic defects are completely rescued by loss of p53 (zeige TP53 ELISA Kits), verifying the crucial role of the MDM2 and/or MDMX (zeige MDM4 ELISA Kits) in regulating p53 (zeige TP53 ELISA Kits) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
Vif (zeige BTG1 ELISA Kits) stabilization by CBFbeta (zeige CBFB ELISA Kits) is mainly caused by impairing MDM2-mediated degradation.
These results demonstrated a critical prosurvival role for MDM2 in the oocytes
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog