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Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy.
Data indicate acquired KRAS, NRAS (zeige NRAS Proteine) or HRAS mutations in more than one third of patients after cetuximab exposure.
HRAS mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (zeige PLAG1 Proteine) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (zeige PLAG1 Proteine) and HMGA2 correlates with the presence of TP53 (zeige TP53 Proteine), FBXW7 (zeige FBXW7 Proteine) mutations, or SMARCB1 (zeige SMARCB1 Proteine) deletion.
Analysis of HRAS mutations and their respiratory phenotype revealed that the common p.Gly12Ser mutation is more often associated with transient respiratory distress and other respiratory diagnoses.
we found that H-Ras proteins and particularly the G12V and G13D variants are significantly more flexible than their K-Ras counterparts.while most of the simulated proteins sampled the effector-interacting state 2 conformational state, G12V and G13D H-Ras adopted an open switch state 1 conformation that is defective in effector interaction
The HRAS mutation p.T58I could manifest with severe early-onset but stabilizing cardiomyopathy. The dysmorphic features are mild compared with the features of Costello syndrome. The phenotypic variability makes the diagnosis challenging, suggesting that this variant of Costello syndrome might go undiagnosed.
Age at diagnosis of follicular thyroid cancer (FTC (zeige FUT2 Proteine)) and frequency of extrathyroidal extension have changed over four decades; prevalence of RAS mutations has decreased; HRAS/NRAS (codon 61) and TERT (zeige TERT Proteine) (promoter) mutations may be associated with poor clinical outcomes in FTC (zeige FUT2 Proteine), especially when two mutations coexist; this retrospective study was conducted in Seoul.
Knockdown of forkhead Box M1 (FoxM1 (zeige FOXM1 Proteine)) reduced Prx (zeige PRDX6 Proteine) II levels in H-ras(G12V)-hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cells, indicating FoxM1 (zeige FOXM1 Proteine) as a direct transcription factor of Prx (zeige PRDX6 Proteine) II in HCC (zeige FAM126A Proteine).
we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 (zeige CIB1 Proteine) expression. We previously described the Ca(2 (zeige CA2 Proteine)+)-myristoyl switch function of CIB1 (zeige CIB1 Proteine), and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1 (zeige SPHK1 Proteine)), a location where SK1 is known to elicit oncogenic signalling.
Data suggest that isoform-specific sequences in the allosteric lobes of HRAS, KRAS, and NRAS (zeige NRAS Proteine) have an impact on biocatalysis (kinetics of GTP (zeige AK3 Proteine) hydrolysis) and interaction with c-Raf (zeige RAF1 Proteine) kinase, which must be due to allosteric effects on dynamics and conformational states, given the identical active sites of these isoenzymes.
Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish
Data demonstrate that H-Ras activation is important in the activation of the specific signaling events leading to the accelerated retinal capillary cell apoptosis in hyperglycemic conditions.
Activation of H-Ras and its downstream signaling pathway in the retina and its vasculature could be under the control of superoxide, and H-Ras activation in diabetes can be prevented by inhibiting superoxide accumulation.
Thrombospondin 1 (zeige THBS1 Proteine), fibronectin (zeige FN1 Proteine), and vitronectin (zeige VTN Proteine) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Proteine) for induction of vascular smooth muscle cell chemotaxis.
Loss of wild-type Hras promotes the earliest stages of pancreatic tumorigenesis, and moreover results in more rapid progression of the disease. As such, mechanisms leading to activation of wild-type Ras proteins, including but not limited to redox-dependent reactions, may influence the development of pancreatic cancer.
High HRAS expression is associated with hepatocarcinogenesis.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (zeige ROCK2 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 Proteine) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 Proteine) loss and novel NF-kappaB (zeige NFKB1 Proteine) expression
this study shows that retinoic acid stabilizes HRas protein during neurogenesis.
we provide genetic evidence that the wild-type H-Ras and K-Ras proteins are bioequivalent in spite of their different structural and biological properties
loss of one allele of Hras increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras allele. However, loss of one or both alleles of Nras (zeige NRAS Proteine) failed to alter tumor burden, either in the absence or presence of Hras, after exposure to urethane.
H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT (zeige AKT1 Proteine)/PI3K signaling pathway.
The long intergenic non-coding RNA CCR492 functions as a let-7 competitive endogenous RNA to de-repress c-Myc (zeige MYC Proteine) expression and to promote cell transformation assisted by the constitutively active H-Ras.
these contrasting signatures precisely match those proposed to confer bias toward Hras(CAA61CTA) versus Braf (zeige BRAF Proteine)(GTG636GAG) mutations in the original tumor sets. Our findings highlight a novel mechanism whereby exposure history acts through strand-biased mutagenesis to specify activation of preferred oncogenes
The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 (zeige BCL2 Proteine) suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
GTP- and GDP-binding peptide B
, GTPase HRas
, Ha-Ras1 proto-oncoprotein
, Ras family small GTP binding protein H-Ras
, c-has/bas p21 protein
, c-ras-Ki-2 activated oncogene
, p19 H-RasIDX protein
, transformation gene: oncogene HAMSV
, transforming protein p21
, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
, Transforming protein p21
, neuroblastoma ras oncogene
, v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
, Harvey ras1 protein
, Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog
, ras p21
, small G-protein H-Ras
, GTPase HRas (Transforming protein p21) (H-Ras-1) (c-H-ras)
, Harvey ras 1
, H-ras 1 protein
, c-Ha-ras p21 protein
, c-Ha-ras transgene
, transforming protein P21