CDKN1A Proteine (CDKN1A)

Bezeichnung:
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) Proteine (CDKN1A)
Auf www.antikoerper-online.de finden Sie aktuell 16 Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDKN1A Antikörper (581) und CDKN1A Kits (24) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 658 CDKN1A Produkte verfügbar.
Synonyme:
CAP20, CCND1, CDKI, Cdkn1, CDKN1A, CIP1, MDA-6, mda6, p16Xic2, P21, p21Cip1, p21WAF, SDI1, si:ch1073-48m5.2, UV96, WAF1
alle Proteine anzeigen Gen GeneID UniProt
CDKN1A 114851  
CDKN1A 1026 P38936
CDKN1A 12575 P39689

Weitere Synonyme anzeigen

CDKN1A Proteine (CDKN1A) nach Spezies

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Am meisten referenzierte CDKN1A Proteine

  1. Human CDKN1A Protein expressed in Escherichia coli (E. coli) - ABIN1098681 : el-Deiry, Harper, OConnor, Velculescu, Canman, Jackman, Pietenpol, Burrell, Hill, Wang: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. in Cancer research 1994 (PubMed)
    Zeige alle 2 Referenzen für 1098681

  2. Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874 : Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)

Weitere Proteine zu CDKN1A Interaktionspartnern

Zebrafish Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Interaktionspartner

  1. We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a

  2. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21, PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.

Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Interaktionspartner

  1. SUMO and p21Cip1 regulate the transit of proteins through the nucleolus; disruption of nucleolar export by DNA damage induces SUMO and p21Cip1 to act as hub proteins to form a multiprotein complex in the nucleolus.

  2. HULC activates p53 (zeige TP53 Proteine)-p21 pathway and promotes nasopharyngeal carcinoma cell growth.

  3. We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a

  4. miRNAs miR (zeige MLXIP Proteine)-106b and miR (zeige MLXIP Proteine)-20a that target p21 were specifically downregulated in HIV-1 infected CD4 (zeige CD4 Proteine)+ T cells.

  5. Increased nuclear localization of p21(WAF1/CIP1) in SPRY2 (zeige SPRY2 Proteine) downregulated colon cancer cells may explain the inhibition of cell proliferation in colon cancer cells.

  6. This article discusses the controversial aspects of the two-faced involvement of p21 in cancer and speculate on how this new information may increase our understanding of its role in cancer pathogenesis. Prevailing notions indicate that p21 might also act as antiapoptotic agent, which may have relevant implications for future therapeutic strategies. [review]

  7. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells

  8. Results provide evidence that Foxp3 (zeige FOXP3 Proteine) is a downstream target of p53 (zeige TP53 Proteine) and that is sufficient to induce p21 expression, ROS (zeige ROS1 Proteine) production and p53 (zeige TP53 Proteine)-mediated senescence.

  9. both in vitro and in vivo studies proved that CypD (zeige CYPD Proteine) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (zeige CYPD Proteine) on the p53 (zeige TP53 Proteine)-p21 pathway participates in oncogene (zeige RAB1A Proteine)-dependent transformation.

  10. The deletion of CBX3 (zeige CBX3 Proteine) directly enforces the expression of CDK6 (zeige CDK6 Proteine) and p21.

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Interaktionspartner

  1. p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) Interaktionspartner

  1. Data show that Emu-Myc (zeige MYC Proteine) mice lacking both p21 and PUMA (zeige BBC3 Proteine) developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC Proteine);p53 (zeige TP53 Proteine)(+/-)mice.

  2. Study reports that p27 (zeige CDKN1B Proteine) normally exerts a negative feedback on p21 expression: p27 (zeige CDKN1B Proteine) directly represses the expression of the transcription factor Pitx2 (zeige PITX2 Proteine) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27 (zeige CDKN1B Proteine), de-repression of Pitx2 (zeige PITX2 Proteine) causes the up-regulation of p21 showing a new mechanism by which p27 (zeige CDKN1B Proteine) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 Proteine) and p21.

  3. p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (zeige ROCK2 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 Proteine) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 Proteine) loss and novel NF-kappaB (zeige NFKB1 Proteine) expression

  4. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells

  5. both in vitro and in vivo studies proved that CypD (zeige CYPD Proteine) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (zeige CYPD Proteine) on the p53 (zeige TP53 Proteine)-p21 pathway participates in oncogene (zeige RAB1A Proteine)-dependent transformation.

  6. FLT3 (zeige FLT3 Proteine)-ITD is capable of inhibiting FLT3 (zeige FLT3 Proteine)-ITD+ cell proliferation through the p21/Pbx1 (zeige PBX1 Proteine) axis

  7. These data reveal a novel role for p21/waf1 in the resolution of inflammation via its ability to control neutrophil apoptosis.

  8. the silencing of Cyclin-dependent kinase 5 (zeige CDK5 Proteine) preventing memory dysfunction

  9. Results show that p21 expression is regulated by OLA1 (zeige OLA1 Proteine) to promote cell proliferation and organogenesis.

  10. AS160 (zeige TBC1D4 Proteine) regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle.

CDKN1A Protein Überblick

Protein Überblick

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Alternative names and synonyms associated with CDKN1A

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (cdkn1a)
  • cyclin-dependent kinase inhibitor 1 (cki1)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A)
  • cyclin-dependent kinase inhibitor 1A (cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (LOC100348489)
  • cyclin-dependent kinase inhibitor 1A (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (p21, Cip1) (Cdkn1a)
  • cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a)
  • CAP20 Protein
  • CCND1 Protein
  • CDKI Protein
  • Cdkn1 Protein
  • CDKN1A Protein
  • CIP1 Protein
  • MDA-6 Protein
  • mda6 Protein
  • p16Xic2 Protein
  • P21 Protein
  • p21Cip1 Protein
  • p21WAF Protein
  • SDI1 Protein
  • si:ch1073-48m5.2 Protein
  • UV96 Protein
  • WAF1 Protein

Bezeichner auf Proteinebene für CDKN1A

cyclin dependent kinase inhibitor p16Xic2 , cyclin-dependent kinase inhibitor 1 , cyclin D1 , cyclin-dependent kinase inhibitor 1A (p21, Cip1) , cip1 , p21 , waf1 , cyclin-dependent kinase inhibitor 1A , cyclin-dependent kinase inhibitor 1A (P21) , CDK-interacting protein 1 , CDK-interaction protein 1 , DNA synthesis inhibitor , melanoma differentiation associated protein 6 , wild-type p53-activated fragment 1 , p21/WAF1 , melanoma differentiation-associated protein , p21

GENE ID SPEZIES
492305 Xenopus laevis
606440 Zea mays
747442 Pan troglodytes
100038054 Xenopus (Silurana) tropicalis
100302083 Ovis aries
100151416 Danio rerio
100348489 Oryctolagus cuniculus
114851 Rattus norvegicus
1026 Homo sapiens
474890 Canis lupus familiaris
513497 Bos taurus
100152215 Sus scrofa
100720449 Cavia porcellus
493943 Felis catus
12575 Mus musculus
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