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Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874
Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21, PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
HOXA11 (zeige HOXA11 Proteine)-AS could simultaneously interact with enhancer of zeste homolog 2 (zeige EZH2 Proteine) to suppress its target p21 protein (zeige NRAS Proteine) expression
The intensity of p21 and Bcl-2 (zeige BCL2 Proteine) expressions in different grades of OSCC indicates a key role in progression of oral neoplasia.
The findings identify that CHD4 (zeige CHD4 Proteine) deficiency preferentially impairs cell survival via increasing the level of p21.
Glyoxalase 2 expression in prostate cancer was dependent on androgen receptor (zeige AR Proteine) and was aimed at stimulating cell proliferation and eluding apoptosis through a mechanism involving the p53 (zeige TP53 Proteine)-p21 axis
data suggest that PUMA (zeige BBC3 Proteine) cooperates with p21 to regulate normal acinus (zeige ACIN1 Proteine) formation and epithelial-to-mesenchymal transition.
LASS5 (zeige LASS5 Proteine) interacts with SDHB (zeige SDHB Proteine) and synergistically represses p53 (zeige TP53 Proteine) and p21 activity.
Schistosoma japonicum egg antigen p40 (zeige IL9 Proteine) through action on the STAT3 (zeige STAT3 Proteine)/p53 (zeige TP53 Proteine)/p21 pathway triggered cellular senescence, while knockdown of p53 (zeige TP53 Proteine) or STAT3 (zeige STAT3 Proteine) partly restored cell senescence.
No mutations in CDKN1A coding region were detected in 39 probands from families with criteria for Li-Fraumeni and Li-Fraumeni like syndromes.
Results suggest that the simultaneous evaluation of SRY (sex determining region Y)-box 2 (zeige SOX2 Proteine) protein (SOX2 (zeige SOX2 Proteine)) and cyclin dependent kinase inhibitor 1A (p21) in advanced endometrial cancer patients provides more accurate information for patient prognosis than either alone.
p21 adjusts the equilibrium between p65 (zeige GORASP1 Proteine)-p50 (zeige CD40 Proteine) and p50-p50 NF-kappaB (zeige NFKB1 Proteine) pathways to mediate macrophage plasticity in LPS (zeige IRF6 Proteine) tolerance
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 (zeige CDK2 Proteine) activity.
The study demonstrates an essential role of Setd2 in myoblast proliferation and differentiation, and uncovers Setd2-mediated molecular mechanism through regulating MyoG (zeige MYOG Proteine) and p21.
Schistosoma japonicum egg antigen p40 (zeige LANCL1 Proteine) through action on the STAT3 (zeige STAT3 Proteine)/p53 (zeige TP53 Proteine)/p21 pathway triggered cellular senescence, while knockdown of p53 (zeige TP53 Proteine) or STAT3 (zeige STAT3 Proteine) partly restored cell senescence.
Data show that Emu-Myc (zeige MYC Proteine) mice lacking both p21 and PUMA (zeige BBC3 Proteine) developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC Proteine);p53 (zeige TP53 Proteine)(+/-)mice.
Study reports that p27 (zeige CDKN1B Proteine) normally exerts a negative feedback on p21 expression: p27 (zeige CDKN1B Proteine) directly represses the expression of the transcription factor Pitx2 (zeige PITX2 Proteine) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27 (zeige CDKN1B Proteine), de-repression of Pitx2 (zeige PITX2 Proteine) causes the up-regulation of p21 showing a new mechanism by which p27 (zeige CDKN1B Proteine) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 Proteine) and p21.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (zeige ROCK2 Proteine)/NF-kappaB (zeige NFKB1 Proteine) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 Proteine) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 Proteine) loss and novel NF-kappaB (zeige NFKB1 Proteine) expression
In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 Proteine)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R Proteine)), in Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine)-deleted MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells. Similar to the effect of Runx1 (zeige RUNX1 Proteine)/Cbfb (zeige CBFB Proteine) deletion, PAR-1 (zeige MARK2 Proteine) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (zeige MLL Proteine)-AF9 (zeige MLLT3 Proteine) cells
both in vitro and in vivo studies proved that CypD (zeige CYPD Proteine) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (zeige CYPD Proteine) on the p53 (zeige TP53 Proteine)-p21 pathway participates in oncogene (zeige RAB1A Proteine)-dependent transformation.
FLT3 (zeige FLT3 Proteine)-ITD is capable of inhibiting FLT3 (zeige FLT3 Proteine)-ITD+ cell proliferation through the p21/Pbx1 (zeige PBX1 Proteine) axis
These data reveal a novel role for p21/waf1 in the resolution of inflammation via its ability to control neutrophil apoptosis.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein