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We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 ELISA Kits), wee1 (zeige WEE1 ELISA Kits), p21, PCNA (zeige PCNA ELISA Kits) and cdk2 (zeige CDK2 ELISA Kits), but only weakly influences cyclin B1 (zeige CCNB1 ELISA Kits), cyclin B2 (zeige CCNB2 ELISA Kits) and cyclin E1 (zeige CCNE1 ELISA Kits) expression.
HOXA11 (zeige HOXA11 ELISA Kits)-AS could simultaneously interact with enhancer of zeste homolog 2 (zeige EZH2 ELISA Kits) to suppress its target p21 protein (zeige NRAS ELISA Kits) expression
The intensity of p21 and Bcl-2 (zeige BCL2 ELISA Kits) expressions in different grades of OSCC indicates a key role in progression of oral neoplasia.
The findings identify that CHD4 (zeige CHD4 ELISA Kits) deficiency preferentially impairs cell survival via increasing the level of p21.
Glyoxalase 2 expression in prostate cancer was dependent on androgen receptor (zeige AR ELISA Kits) and was aimed at stimulating cell proliferation and eluding apoptosis through a mechanism involving the p53 (zeige TP53 ELISA Kits)-p21 axis
data suggest that PUMA (zeige BBC3 ELISA Kits) cooperates with p21 to regulate normal acinus (zeige ACIN1 ELISA Kits) formation and epithelial-to-mesenchymal transition.
LASS5 interacts with SDHB (zeige SDHB ELISA Kits) and synergistically represses p53 (zeige TP53 ELISA Kits) and p21 activity.
Schistosoma japonicum egg antigen p40 (zeige IL9 ELISA Kits) through action on the STAT3 (zeige STAT3 ELISA Kits)/p53 (zeige TP53 ELISA Kits)/p21 pathway triggered cellular senescence, while knockdown of p53 (zeige TP53 ELISA Kits) or STAT3 (zeige STAT3 ELISA Kits) partly restored cell senescence.
No mutations in CDKN1A coding region were detected in 39 probands from families with criteria for Li-Fraumeni and Li-Fraumeni like syndromes.
Results suggest that the simultaneous evaluation of SRY (sex determining region Y)-box 2 (zeige SOX2 ELISA Kits) protein (SOX2 (zeige SOX2 ELISA Kits)) and cyclin dependent kinase inhibitor 1A (p21) in advanced endometrial cancer patients provides more accurate information for patient prognosis than either alone.
p21 adjusts the equilibrium between p65 (zeige GORASP1 ELISA Kits)-p50 (zeige CD40 ELISA Kits) and p50-p50 NF-kappaB (zeige NFKB1 ELISA Kits) pathways to mediate macrophage plasticity in LPS (zeige IRF6 ELISA Kits) tolerance
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 (zeige CDK2 ELISA Kits) activity.
The study demonstrates an essential role of Setd2 in myoblast proliferation and differentiation, and uncovers Setd2-mediated molecular mechanism through regulating MyoG (zeige MYOG ELISA Kits) and p21.
Schistosoma japonicum egg antigen p40 (zeige LANCL1 ELISA Kits) through action on the STAT3 (zeige STAT3 ELISA Kits)/p53 (zeige TP53 ELISA Kits)/p21 pathway triggered cellular senescence, while knockdown of p53 (zeige TP53 ELISA Kits) or STAT3 (zeige STAT3 ELISA Kits) partly restored cell senescence.
Data show that Emu-Myc (zeige MYC ELISA Kits) mice lacking both p21 and PUMA (zeige BBC3 ELISA Kits) developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC ELISA Kits);p53 (zeige TP53 ELISA Kits)(+/-)mice.
Study reports that p27 (zeige CDKN1B ELISA Kits) normally exerts a negative feedback on p21 expression: p27 (zeige CDKN1B ELISA Kits) directly represses the expression of the transcription factor Pitx2 (zeige PITX2 ELISA Kits) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27 (zeige CDKN1B ELISA Kits), de-repression of Pitx2 (zeige PITX2 ELISA Kits) causes the up-regulation of p21 showing a new mechanism by which p27 (zeige CDKN1B ELISA Kits) regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (zeige PITX2 ELISA Kits) and p21.
p21-associated inhibition of early-stage malignant progression and the intense expression in papilloma outgrowths, identifies a novel, significant antagonism between p21 and ras(Ha)/ROCK2 (zeige ROCK2 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) signalling in skin carcinogenesis.these data show that ROCK2 (zeige ROCK2 ELISA Kits) activation induces malignancy in ras(Ha)-initiated/promoted papillomas in the context of p53 (zeige TP53 ELISA Kits) loss and novel NF-kappaB (zeige NFKB1 ELISA Kits) expression
In this study, we found upregulation of several hemostasis-related genes, including the thrombin (zeige F2 ELISA Kits)-activatable receptor PAR-1 (protease-activated receptor-1 (zeige F2R ELISA Kits)), in Runx1 (zeige RUNX1 ELISA Kits)/Cbfb (zeige CBFB ELISA Kits)-deleted MLL (zeige MLL ELISA Kits)-AF9 (zeige MLLT3 ELISA Kits) cells. Similar to the effect of Runx1 (zeige RUNX1 ELISA Kits)/Cbfb (zeige CBFB ELISA Kits) deletion, PAR-1 (zeige MARK2 ELISA Kits) overexpression induced CDKN1A/p21 expression and attenuated proliferation in MLL (zeige MLL ELISA Kits)-AF9 (zeige MLLT3 ELISA Kits) cells
both in vitro and in vivo studies proved that CypD (zeige CYPD ELISA Kits) inhibitor-based treatment was able to efficiently impair this interaction, leading to a tumor formation reduction. All together, these findings indicate that the countering effect of CypD (zeige CYPD ELISA Kits) on the p53 (zeige TP53 ELISA Kits)-p21 pathway participates in oncogene (zeige RAB1A ELISA Kits)-dependent transformation.
FLT3 (zeige FLT3 ELISA Kits)-ITD is capable of inhibiting FLT3 (zeige FLT3 ELISA Kits)-ITD+ cell proliferation through the p21/Pbx1 (zeige PBX1 ELISA Kits) axis
These data reveal a novel role for p21/waf1 in the resolution of inflammation via its ability to control neutrophil apoptosis.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein