Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 ELISA Kits), wee1 (zeige WEE1 ELISA Kits), p21, PCNA (zeige PCNA ELISA Kits) and cdk2 (zeige CDK2 ELISA Kits), but only weakly influences cyclin B1 (zeige CCNB1 ELISA Kits), cyclin B2 (zeige CCNB2 ELISA Kits) and cyclin E1 (zeige CCNE1 ELISA Kits) expression.
Nurr1 (zeige NR4A2 ELISA Kits) was induced during intestinal regeneration after I/R injury. Nurr1 (zeige NR4A2 ELISA Kits) promoted proliferation of intestinal epithelial cells after H/R injury. Nurr1 (zeige NR4A2 ELISA Kits) inhibited p21 expression in a p53 (zeige TP53 ELISA Kits)-independent manner. Nurr1 (zeige NR4A2 ELISA Kits) inhibited p21 gene transcription by binding to p21 promoter directly.
Germline mutations in TERT (zeige TERT ELISA Kits) (rs2736100, n = 33) and CDKN1A (rs2395655, n = 27) associated with idiopathic pulmonary fibrosis risk were detected in most samples.
methylation at m6A (zeige GPM6A ELISA Kits) by METTL3 (zeige METTL3 ELISA Kits)/METTL14 (zeige METTL14 ELISA Kits) facilitates the methylation of m5C by NSUN2 (zeige NSUN2 ELISA Kits), and vice versa. NSUN2 (zeige NSUN2 ELISA Kits)-mediated m5C and METTL3 (zeige METTL3 ELISA Kits)/METTL14 (zeige METTL14 ELISA Kits)-mediated m6A (zeige GPM6A ELISA Kits) methylation synergistically enhance p21 expression at the translational level
Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).
Results show that p21CIP1 expression is regulated by IL9 (zeige IL9 ELISA Kits) in diffuse large B-cell lymphoma.
Results demonstrated that dsRNA-mediated p21 induction in human cell lines is a common phenomenon. This process occurs at the transcriptional level, and the complementary p21 promoter is the intended dsRNA target.
expression of p21 potentially can contribute to inhibition of HIV-1 replication in monocyte-derived dendritic cells through multiple mechanisms. p21 decreased size of the intracellular dNTP pool; p21 prevented SAMHD1 (zeige SAMHD1 ELISA Kits) phosphorylation and promoted SAMHD1 (zeige SAMHD1 ELISA Kits) dNTPase-independent antiviral activity
C5a/C5aR pathway promotes gastric cancer pathogenesis by suppressing p21/p-p21 expression via activation of PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits) signaling.
p21 expression showed a significant positive correlation with tumoral FOXP3 (zeige FOXP3 ELISA Kits) expression in gastric adenocarcinoma cells.
The PPARgamma (zeige PPARG ELISA Kits)-SETD8 (zeige SETD8 ELISA Kits) axis constitutes an epigenetic, p53 (zeige TP53 ELISA Kits)-independent checkpoint on p21-mediated cellular senescence.
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
our genetic and biochemical data show an important function of p21 in the regulation of growth-related processes in the heart.
The Smad3 (zeige SMAD3 ELISA Kits) and Bmal1 (zeige ARNTL ELISA Kits) regulate p21 and S100A4 (zeige S100A4 ELISA Kits) expression in myocardial stromal fibroblasts through TNF-alpha (zeige TNF ELISA Kits).
Data suggest BAF180 (zeige PBRM1 ELISA Kits) protein as a critical regulator of cellular senescence and HSC (zeige FUT1 ELISA Kits) homeostasis, which is at least partially regulated through BAF180 (zeige PBRM1 ELISA Kits)-mediated suppression of cell cycle regulator p21 expression.
Histone methyltransferase Suv39h1 (zeige SUV39H1 ELISA Kits) attenuates high glucose-induced fibronectin (zeige FN1 ELISA Kits) and p21(WAF1) in mesangial cells
It has been observed that even in tissues with no detectable Linc-p21 transcript, deletion of the locus significantly affects local gene expression, including of the cell cycle regulator Cdkn1a.
The findings suggest that p21 facilitates the development of cardiac hypertrophy, and regulating the expression of p21 may be an approach to attenuate hypertrophic growth of cardiomyocytes.
Ad-p21 inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 (zeige CDK2 ELISA Kits) activity.
The study demonstrates an essential role of Setd2 in myoblast proliferation and differentiation, and uncovers Setd2-mediated molecular mechanism through regulating MyoG (zeige MYOG ELISA Kits) and p21.
Schistosoma japonicum egg antigen p40 (zeige LANCL1 ELISA Kits) through action on the STAT3 (zeige STAT3 ELISA Kits)/p53 (zeige TP53 ELISA Kits)/p21 pathway triggered cellular senescence, while knockdown of p53 (zeige TP53 ELISA Kits) or STAT3 (zeige STAT3 ELISA Kits) partly restored cell senescence.
Data show that Emu-Myc (zeige MYC ELISA Kits) mice lacking both p21 and PUMA (zeige BBC3 ELISA Kits) developed lymphoma at a rate considerably longer latency than Emu-Myc (zeige MYC ELISA Kits);p53 (zeige TP53 ELISA Kits)(+/-)mice.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein