anti-ATM (ATM) Antikörper

Bezeichnung:
anti-Ataxia Telangiectasia Mutated Antikörper (ATM)
Auf www.antikoerper-online.de finden Sie aktuell 355 Ataxia Telangiectasia Mutated (ATM) Antikörper von 32 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ATM Kits (46) und ATM Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 420 ATM Produkte verfügbar.
Synonyme:
AI256621, AT1, ATA, ATC, ATD, ATDC, ATE, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, TEL1, TELO1, Xatm

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Am meisten referenzierte anti-ATM Antikörper

  1. Human Monoclonal ATM Primary Antibody für ChIP, ELISA - ABIN151775 : Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 114 Referenzen für 151775

  2. Human Polyclonal ATM Primary Antibody für ICC, FACS - ABIN151030 : Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005 (PubMed)
    Zeige alle 76 Referenzen für 151030

  3. Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN151772 : Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008 (PubMed)
    Zeige alle 19 Referenzen für 151772

  4. Human Polyclonal ATM Primary Antibody für IF, WB - ABIN319313 : Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: Involvement of human MOF in ATM function. in Molecular and cellular biology 2005 (PubMed)
    Zeige alle 4 Referenzen für 319313

  5. Human Polyclonal ATM Primary Antibody für IHC (p) - ABIN196822 : Bernstein, Seminara, Børresen-Dale: Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002. in Breast cancer research : BCR 2002 (PubMed)
    Zeige alle 4 Referenzen für 196822

  6. Human Polyclonal ATM Primary Antibody für IP, PLA - ABIN151739 : Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006 (PubMed)
    Zeige alle 4 Referenzen für 151739

  7. Human Monoclonal ATM Primary Antibody für WB - ABIN1449283 : Canman, Lim, Cimprich, Taya, Tamai, Sakaguchi, Appella, Kastan, Siliciano: Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. in Science (New York, N.Y.) 1998 (PubMed)
    Zeige alle 3 Referenzen für 1449283

  8. Human Monoclonal ATM Primary Antibody für ICC, IF - ABIN2668604 : Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009 (PubMed)
    Zeige alle 3 Referenzen für 2668604

  9. Human Polyclonal ATM Primary Antibody für EIA - ABIN358435 : Brunet, Gutiérrez-Enríquez, Torres, Bérez, Sanjosé, Galceran, Izquierdo, Menéndez, Gumà, Borràs: ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations. in Clinical genetics 2008 (PubMed)
    Zeige alle 2 Referenzen für 358435

  10. Human Polyclonal ATM Primary Antibody für DB, IF - ABIN389888 : Tsai, Chung, Takahashi, Xu, Hu: Functional interaction between FOXO3a and ATM regulates DNA damage response. in Nature cell biology 2008 (PubMed)
    Zeige alle 2 Referenzen für 389888

Weitere Antikörper gegen ATM Interaktionspartner

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  2. TCTP (zeige TPT1 Antikörper) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

  3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

  4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

  5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

  6. ATM checkpoint kinase (zeige ATR Antikörper) plays a role in telomere maintenance that is independent of telomerase regulation.

  7. Drosophila ATM and Mre11 (zeige MRE11A Antikörper) are essential for the G2/M checkpoint induced by low-dose irradiation.

  8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. Dna2 (zeige DNA2 Antikörper) co-localizes in foci with RPA (zeige RPA1 Antikörper) and is found in a complex with replication fork components And-1 and Mcm10 (zeige MCM10 Antikörper). Dna2 (zeige DNA2 Antikörper) interacts with the DSB repair and checkpoint proteins Nbs1 (zeige NLRP2 Antikörper) and ATM.

  2. ATM and ATR (zeige ATR Antikörper) prevent accumulation of chromosomal abnormalities by promoting Mre11 (zeige MRE11A Antikörper)/Rad50 (zeige RAD50 Antikörper)/Nbs1 (zeige NLRP2 Antikörper) dependent recovery of collapsed replication forks.

  3. ATM and ATR (zeige ATR Antikörper) phosphorylate the functionally critical replication protein Mcm2 (zeige MCM2 Antikörper) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (zeige TOPBP1 Antikörper) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (zeige TOPBP1 Antikörper) with ATR (zeige ATR Antikörper)(ATM and Rad3-related).

  6. ATM and ATR (zeige ATR Antikörper) control mitotic events in vertebrate cells by targeting CEP63 (zeige CEP63 Antikörper) and centrosome dependent spindle assembly.

  7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (zeige TOPBP1 Antikörper)-dependent activation of ATR (zeige ATR Antikörper)-ATRIP (zeige ATRIP Antikörper) in response to double-stranded DNA breaks.

  8. The Fanconi anemia protein (zeige FANCF Antikörper) FANCM (zeige FANCM Antikörper) is controlled by FANCD2 (zeige FANCD2 Antikörper) and the ATR (zeige ATR Antikörper)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

  2. Characterization of ataxia (zeige USP14 PLURAL_@14456@) telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. We report that endogenous huntingtin (zeige HTT Antikörper) protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin (zeige HTT Antikörper) in live cells, we show that localization of huntingtin (zeige HTT Antikörper) to DNA damage sites is dependent on the kinase activity of ataxia telangiectasia mutated (ATM) protein.

  2. The study showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

  3. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (zeige PALB2 Antikörper), CHEK2 (zeige CHEK2 Antikörper) and ATM

  4. Taken together, the findings suggest that a protein-protein interaction between ATM and p400 (zeige EP400 Antikörper) ATPase (zeige DNAH8 Antikörper) occurs independently of DNA damage and contributes to efficient DNA damage response and repair.

  5. following reprogramming the early and late replicating genome is differentially affected by copy number variations in ATM-deficient induced pluripotent stem cells (iPSCs) relative to wild-type iPSCs.

  6. ATM mutation is associated with ataxia (zeige USP14 PLURAL_@14456@)-telangiectasia.

  7. Results provide evidence that ATM along with 53BP1 (zeige TP53BP1 Antikörper) is involved in breast cancer cells resistance for PARP (zeige COL11A2 Antikörper) inhibitor; its deficiency causes resistance in 53BP1 (zeige TP53BP1 Antikörper)-depleted tumor cells.

  8. WRNIP1 (zeige WRNIP1 Antikörper) connects PCNA (zeige PCNA Antikörper) monoubiquitination with ATMIN (zeige ATMIN Antikörper)/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  9. Mutant IDH1 (zeige IDH1 Antikörper) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (zeige FUT1 Antikörper) self-renewal, independent of TET2 (zeige TET2 Antikörper).

  10. ATM rs189037 polymorphism is associated with reduced risk of T2DM

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. Ataxia (zeige USP14 PLURAL_@14456@) telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

  2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

  3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. radiation-induced eNOS (zeige NOS3 Antikörper) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (zeige HSP90 Antikörper)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)-regulated apoptosis and the p53 (zeige TP53 Antikörper)/PCNA (zeige PCNA Antikörper)- and ATM/ATR (zeige ATR Antikörper)-Chk1 (zeige CHEK1 Antikörper)/2-controlled DNA-damage response pathways.

  2. this study shows that Atm-/- mice are more susceptible to pulmonary Streptococcus pneumoniae infection in a manner consistent with inflammasome defects

  3. This study show that like ataxia (zeige USP14 Antikörper) telangiectasia cells, ISG15 (zeige ISG15 Antikörper) is elevated in Atm-deficient mouse cerebellums.

  4. This study identifies attenuation of type I interferon (zeige IFNA Antikörper) responses as the primary mechanism underlying proviral function of ATM during gammaherpesvirus infection.

  5. Mutant IDH1 (zeige IDH1 Antikörper) downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC (zeige FUT1 Antikörper) self-renewal, independent of TET2 (zeige TET2 Antikörper).

  6. USP7 (zeige USP7 Antikörper) inhibition is selectively cytotoxic to CLL cells independently of ATM and p53 (zeige TP53 Antikörper) and synergizes with chemotherapy.

  7. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53 (zeige TP53 Antikörper)/Atm-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (zeige CRK Antikörper) in response to prolonged exposure to IR.

  8. ATM, ATR (zeige ATR Antikörper) and DNA-PKcs (zeige PRKDC Antikörper) have unique and essential roles during the DNA damage response in the nervous system.

  9. TRAF6 (zeige TRAF6 Antikörper) and H2AX (zeige H2AFX Antikörper) overexpression and gammaH2AX (zeige H2AFX Antikörper)-mediated HIF1alpha (zeige HIF1A Antikörper) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (zeige HIF1A Antikörper)-driven tumorigenesis, glycolysis and metastasis.

  10. These results reveal a new requirement for ATMIN (zeige ATMIN Antikörper)-dependent ATM signaling in TP53 (zeige TP53 Antikörper)-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

ATM Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Alternative names and synonyms associated with ATM

  • telomere fusion (tefu) Antikörper
  • ataxia telangiectasia mutated (atm) Antikörper
  • ataxia telangiectasia mutated (ATM) Antikörper
  • ataxia telangiectasia mutated (EDI_100660) Antikörper
  • ataxia telangiectasia mutated (CpipJ_CPIJ001772) Antikörper
  • ataxia telangiectasia mutated (BDBG_08252) Antikörper
  • ataxia telangiectasia mutated (PAAG_02532) Antikörper
  • ataxia telangiectasia mutated (MCYG_05088) Antikörper
  • ataxia telangiectasia mutated (VDBG_06833) Antikörper
  • ataxia telangiectasia mutated (atm) (ACLA_015700) Antikörper
  • ataxia telangiectasia mutated (atm) (AaeL_AAEL014900) Antikörper
  • ataxia telangiectasia mutated (MGYG_07634) Antikörper
  • ataxia telangiectasia mutated (PGTG_14279) Antikörper
  • ataxia telangiectasia mutated (Atm) Antikörper
  • ataxia telangiectasia mutated (LOC100349299) Antikörper
  • ataxia telangiectasia mutated homolog (human) (Atm) Antikörper
  • AI256621 Antikörper
  • AT1 Antikörper
  • ATA Antikörper
  • ATC Antikörper
  • ATD Antikörper
  • ATDC Antikörper
  • ATE Antikörper
  • atm Antikörper
  • atm/tefu Antikörper
  • C030026E19Rik Antikörper
  • CG6535 Antikörper
  • dATM Antikörper
  • Dmel\\CG6535 Antikörper
  • tef Antikörper
  • Tefu Antikörper
  • TEL1 Antikörper
  • TELO1 Antikörper
  • Xatm Antikörper

Bezeichner auf Proteinebene für ATM

CG6535-PB , ataxia telangiectasia mutated , ataxia telengiesctasia mutated , ataxia-telangiectasia mutated , drosophila ATM , tefu-PB , chunp9624 , ataxia telangiectasia mutated (includes complementation groups A, C and D) , ataxia telangiectasia mutated protein , serine-protein kinase ATM-like , ataxia telangiectasia mutated (atm) , A-T mutated , AT mutated , TEL1, telomere maintenance 1, homolog , serine-protein kinase ATM , Ataxia telangiectasia gene mutated in human beings , ataxia telangiectasia mutated homolog , A-T mutated homolog , ATM (ataxia telangiectasia mutated) , ataxia telangiectasia gene mutated in human beings

GENE ID SPEZIES
41839 Drosophila melanogaster
398148 Xenopus laevis
403064 Danio rerio
451530 Pan troglodytes
577188 Strongylocentrotus purpuratus
5882524 Entamoeba dispar SAW760
6032926 Culex quinquefasciatus
8501759 Ajellomyces dermatitidis SLH14081
9099145 Paracoccidioides sp. 'lutzii' Pb01
9230975 Arthroderma otae CBS 113480
9537397 Verticillium alfalfae VaMs.102
100026797 Monodelphis domestica
100061765 Equus caballus
100217707 Taeniopygia guttata
100427400 Macaca mulatta
100451505 Pongo abelii
100480638 Ailuropoda melanoleuca
4706457 Aspergillus clavatus NRRL 1
5565620 Aedes aegypti
10025630 Arthroderma gypseum CBS 118893
10535503 Puccinia graminis f. sp. tritici CRL 75-36-700-3
472 Homo sapiens
300711 Rattus norvegicus
100349299 Oryctolagus cuniculus
100717983 Cavia porcellus
100101922 Sus scrofa
479450 Canis lupus familiaris
526824 Bos taurus
395401 Gallus gallus
101105847 Ovis aries
11920 Mus musculus
Ausgewählte Anbieter für anti-ATM (ATM) Antikörper
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