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anti-APAF1 (APAF1) Antikörper

Bezeichnung:
anti-Apoptotic Peptidase Activating Factor 1 Antikörper (APAF1)
Auf www.antikoerper-online.de finden Sie aktuell 211 Apoptotic Peptidase Activating Factor 1 (APAF1) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APAF1 Kits (43) und APAF1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 269 APAF1 Produkte verfügbar.
Synonyme:
6230400I06Rik, anon-53Fa, APAF-1, apaf1, Apaf1l, arc, ark, CED4, CG6829, D-Apaf-1, dapaf, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, hac-1, Hac-1/Dark, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543

Meistgesuchte Reaktivitäten zu anti-APAF1 (APAF1) Antikörper

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anti-Human APAF1 Antikörper:

anti-Mouse (Murine) APAF1 Antikörper:

anti-Rat (Rattus) APAF1 Antikörper:

Alle verfügbaren anti-APAF1 Antikörper

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Am meisten referenzierte anti-APAF1 Antikörper

  1. Human Polyclonal APAF1 Primary Antibody für WB - ABIN967648 : Cecconi, Alvarez-Bolado, Meyer, Roth, Gruss: Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. in Cell 1998 (PubMed)
    Zeige alle 6 Referenzen für ABIN967648

  2. Human Monoclonal APAF1 Primary Antibody für IF, WB - ABIN968496 : Cain, Brown, Langlais, Cohen: Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. in The Journal of biological chemistry 1999 (PubMed)
    Zeige alle 5 Referenzen für ABIN968496

  3. Human Monoclonal APAF1 Primary Antibody für EIA, IHC (fro) - ABIN400811 : Zou, Henzel, Liu, Lutschg, Wang: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. in Cell 1997 (PubMed)
    Zeige alle 4 Referenzen für ABIN400811

  4. Cow (Bovine) Polyclonal APAF1 Primary Antibody für WB - ABIN222876 : Dirks, Leeuwenburgh: Apoptosis in skeletal muscle with aging. in American journal of physiology. Regulatory, integrative and comparative physiology 2002 (PubMed)
    Zeige alle 4 Referenzen für ABIN222876

  5. Human Polyclonal APAF1 Primary Antibody für EIA, IHC (p) - ABIN499289 : Li, Nijhawan, Budihardjo, Srinivasula, Ahmad, Alnemri, Wang: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. in Cell 1997 (PubMed)
    Zeige alle 4 Referenzen für ABIN499289

  6. Human Polyclonal APAF1 Primary Antibody für EIA, IHC (p) - ABIN499287 : Hu, Benedict, Wu, Inohara, Núñez: Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Zeige alle 4 Referenzen für ABIN499287

  7. Gerbil Polyclonal APAF1 Primary Antibody für ICC, IHC (fro) - ABIN252079 : Kim, Lee, Park, Chung, Im, Noh, Han, Moon, Jung, Ryu: Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. in Virchows Archiv : an international journal of pathology 2015 (PubMed)

Weitere Antikörper gegen APAF1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Apoptotic Peptidase Activating Factor 1 (APAF1) Interaktionspartner

  1. polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis

  2. structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]

  3. ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.

  4. Daxx (zeige DAXX Antikörper)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level

Human Apoptotic Peptidase Activating Factor 1 (APAF1) Interaktionspartner

  1. the markers Ets-1 (zeige ETS1 Antikörper) and APAF-1 relative to p53 (zeige TP53 Antikörper), Ki-67 (zeige MKI67 Antikörper) and PTEN (zeige PTEN Antikörper) expression in colon adenomas/polyps, were investigated.

  2. Different selenium concentrations had varying effects on BAK1 (zeige BAK1 Antikörper) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD

  3. miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (zeige TBX1 Antikörper)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.

  4. HDAC (zeige HDAC3 Antikörper) inhibitors can induce p53 (zeige TP53 Antikörper) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.

  5. Renal APAF1 expression is increased in diabetes and diabetic nephropathy.

  6. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  7. These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.

  8. The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.

  9. cytochrome c (zeige CYCS Antikörper) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly

  10. NF-kappaB (zeige NFKB1 Antikörper) response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO (zeige ZBTB33 Antikörper) and p53 (zeige TP53 Antikörper)

Mouse (Murine) Apoptotic Peptidase Activating Factor 1 (APAF1) Interaktionspartner

  1. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death

  2. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  3. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.

  4. study demonstrates that MMP-3 (zeige MMP3 Antikörper) leads to caspase-9 (zeige CASP9 Antikörper) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

  5. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

  6. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (zeige HSP70 Antikörper)

  7. miR (zeige MLXIP Antikörper)-23a/b and miR (zeige MLXIP Antikörper)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.

  8. a role for Apaf1 at the mitochondria

  9. The Apaf-1-independent caspase (zeige CASP3 Antikörper) activation was not inhibited by Bcl-2 (zeige BCL2 Antikörper), and occurred without the release of cytochrome c (zeige CYCS Antikörper) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.

  10. These data are consistent with a model in which alterations of GH signaling and/or insulin (zeige INS Antikörper) sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes.

Pig (Porcine) Apoptotic Peptidase Activating Factor 1 (APAF1) Interaktionspartner

  1. Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (zeige BIRC2 Antikörper).

Zebrafish Apoptotic Peptidase Activating Factor 1 (APAF1) Interaktionspartner

  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

APAF1 Antigen-Profil

Beschreibung des Gens

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with APAF1

  • Apaf-1-related-killer (Ark) Antikörper
  • apoptotic peptidase activating factor 1 (apaf1) Antikörper
  • apoptotic peptidase activating factor 1 (APAF1) Antikörper
  • apoptotic peptidase activating factor 1 (Apaf1) Antikörper
  • apoptotic protease activating factor 1 (apaf1) Antikörper
  • 6230400I06Rik Antikörper
  • anon-53Fa Antikörper
  • APAF-1 Antikörper
  • apaf1 Antikörper
  • Apaf1l Antikörper
  • arc Antikörper
  • ark Antikörper
  • CED4 Antikörper
  • CG6829 Antikörper
  • D-Apaf-1 Antikörper
  • dapaf Antikörper
  • dapaf-1 Antikörper
  • dApaf-1/DARK/HAC-1 Antikörper
  • Dapaf-1/HAC-1 Antikörper
  • dapaf-1L Antikörper
  • dapaf-1S Antikörper
  • dApaf1 Antikörper
  • dark Antikörper
  • Dark/Apaf-I Antikörper
  • dark/dapaf-1/hac-1 Antikörper
  • Dark/Dapaf-1/HAC1 Antikörper
  • dark/hac-1/dapaf-1 Antikörper
  • Dark/Hac-1/dApaf1 Antikörper
  • Dmel\\CG6829 Antikörper
  • fog Antikörper
  • hac-1 Antikörper
  • Hac-1/Dark Antikörper
  • hac1 Antikörper
  • l(2)SH0173 Antikörper
  • mKIAA0413 Antikörper
  • T1 Antikörper
  • zgc:136543 Antikörper

Bezeichner auf Proteinebene für APAF1

Apaf-1 related , Apaf-1 related killer , Apaf-1-related killer , Ark-PA , Ark-PB , CG6829-PA , CG6829-PB , apaf1-related killer , dark , drosophila Apaf-1-related killer , lethal (2) SH0173 , transcription unit 1 , apoptotic peptidase activating factor 1 , apoptotic protease-activating factor 1-like , apoptotic protease-activating factor 1 , apoptotic protease activating factor 1 , forebrain overgrowth , apaf-1

GENE ID SPEZIES
36914 Drosophila melanogaster
444261 Xenopus laevis
100127738 Xenopus (Silurana) tropicalis
452153 Pan troglodytes
694164 Macaca mulatta
768257 Felis catus
100013051 Monodelphis domestica
100459074 Pongo abelii
100464163 Ailuropoda melanoleuca
100549497 Meleagris gallopavo
100556318 Anolis carolinensis
100590369 Nomascus leucogenys
317 Homo sapiens
11783 Mus musculus
78963 Rattus norvegicus
537782 Bos taurus
482620 Canis lupus familiaris
417926 Gallus gallus
100719903 Cavia porcellus
100513283 Sus scrofa
100052552 Equus caballus
100135699 Ovis aries
58131 Danio rerio
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