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the finding of this meta-analysis concluded that VDR (zeige CYP27B1 Proteine) Bsm1, Apa1 (zeige ZNF410 Proteine), Fok1, and Poly (A) gene polymorphisms may be susceptible for breast cancer development
1,25(OH)2D3 indirectly modulates the differentiation of Treg/Th17 cells by a ff ;ecting the VDR (zeige CYP27B1 Proteine)/PLC-gamma1 (zeige PLCG1 Proteine)/TGF-beta1pathway. These results indicate that administration 1,25(OH)2D3 supplements may be a beneficial treatment for organ transplantation recipients.
In conclusion, vitamin D receptors ApaI and TaqI confer high breast cancer susceptibility, particularly in Egyptians females carrying haplotype ATT. However, further studies focusing on the vitamin D receptor variants and haplotypes effects on vitamin D and vitamin D receptor concentrations, activities, and functionalities are needed.
The strength of associations between polymorphisms of vitamin D receptor and cancer risk.
Our results indicated that 25(OH) vitamin D, MMP-9 levels and VDR gene FokI polymorphisms play a critical role in the development and progression of CAD and may contribute to susceptibility to CAD in Iranian populations.
The findings implied that low vitamin D levels might be associated with an increased risk for hepatitis C virus (HCV) infection and chronicity, and favorable VDR (zeige CYP27B1 Proteine) variants (rs7975232-C, rs2239185-T and rs11574129-T) might contribute to a decreased susceptibility to HCV infection in a high-risk Chinese population.
In elderly subjects, adequate serum vitamin D concentrations are involved in the homeostasis of glucose metabolism and oxidative stress. The BsmI polymorphism has a significant effect on the lipid profile, suggesting the influence of VDR (zeige CYP27B1 Proteine) function in fatty acid metabolism.
Vitamin D receptor gene Cdx2 (zeige CDX2 Proteine) and Apa1 (zeige ZNF410 Proteine) polymorphisms are not associated with prostate cancer.
Polymorphic variations in VDR (zeige CYP27B1 Proteine) and CASR (zeige CASR Proteine) may be associated with survival after a diagnosis of colorectal neoplasms.
Study identified an association between VDR (zeige CYP27B1 Proteine) polymorphisms with lung cancer risk in the Polish population and points toward the possible association between low 25(OH)D serum concentration and an increased likelihood of disease.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (zeige TNF Proteine) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (zeige NOS2 Proteine)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (zeige NOS2 Proteine) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
Loss of the vitamin D receptor in macrophages and granulocytes mildly affected colitis-associated symptoms but greatly increased proinflammatory cytokine expression in the inflamed colon, suggesting a prominent role for innate immune cell vitamin D signaling in controlling gut (zeige GUSB Proteine) inflammation.
Vdr (zeige CYP27B1 Proteine) and Casr (zeige CASR Proteine) are required for beta-catenin (zeige CTNNB1 Proteine)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.
Absence of VDR (zeige CYP27B1 Proteine)-mediated PPARgamma (zeige PPARG Proteine) suppression underlies alopecia in VDR (zeige CYP27B1 Proteine)-/- mice.
Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.
VDR (zeige CYP27B1 Proteine) is important for the maintenance of physiological level of Axin1 (zeige AXIN1 Proteine)
The data support the hypothesis that Vdr (zeige CYP27B1 Proteine) in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.
The data demonstrate that deficiency in the vitamin D signaling via VDR (zeige CYP27B1 Proteine) knockout enhances the pathological phenotype in this experimental cardiomyopathy and suggest an important role for vitamin D in modulating disease severity in common cardiovascular disorders.
Absence of VDR (zeige CYP27B1 Proteine) or presence of an unliganded VDR (zeige CYP27B1 Proteine) does not affect the profile and function of ex vivo generated bone marrow-derived dendritic cells.
JNK1 (zeige MAPK8 Proteine) physically and functionally interacted with VDR (zeige CYP27B1 Proteine) and positively regulated VDR (zeige CYP27B1 Proteine) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.
Vitamin D receptor activation reduces dissecting abdominal aortic aneurysm formation induced by Ang-II (zeige AGT Proteine) in apoE (zeige APOE Proteine)(-/-) mice
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor