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The studies performed did not confirm the ability of the SF1 insulator to protect expression of reporter gene white from the chromosome position effect in transgenic lines.
we found that KLF6 (zeige KLF6 ELISA Kits) transcriptionally cooperates with NUR77 (zeige NR4A1 ELISA Kits) and SF1
Data suggest that Ad4BP (zeige NR5A1 ELISA Kits) plays role in regulation of intracellular NADPH (zeige FDXR ELISA Kits) concentration via transcription of Me1 (zeige ME1 ELISA Kits) and Mthfd2 (zeige MTHFD2 ELISA Kits) genes in adrenocortical cells. (Ad4BP (zeige NR5A1 ELISA Kits) = nuclear receptor subfamily 5 group A member 1 (zeige NR5A1 ELISA Kits); Me1 (zeige ME1 ELISA Kits) = malic enzyme 1 (zeige ME1 ELISA Kits); Mthfd2 (zeige MTHFD2 ELISA Kits) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
WT1 (zeige WT1 ELISA Kits) is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 expression. Without Wt1 (zeige WT1 ELISA Kits), the expression of Sf1 was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
SF1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity.
Data suggest that Sf1 and c-jun interact and cooperate to activate the Fdx1 promoter in MA-10 (tumorigenic cell line) and TM3 (non-tumorigenic cell line) Leydig cells; such activation requires different regulatory elements located between -124 and -306 bp of Fdx1 promoter and involves recruitment of Sf1 to this region. (Sf1 = splicing factor 1; c-jun = proto-oncogene c-jun; Fdx1 = ferredoxin 1)
Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (zeige NR5A1 ELISA Kits) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (zeige STAR ELISA Kits) and CYP11A1 (zeige CYP11A1 ELISA Kits), and a resulting increase in unmetabolized cholesterol.
The results of the current study show that EB treatment from P25 (zeige CDK5R1 ELISA Kits) to P36 (zeige ANXA2 ELISA Kits) could not restore the number of kisspeptin-ir cells in the AVPV in agonadal SF-1 KO mice to numbers found in gonadally intact WT or EB-treated WT/OVX females
the data suggest that the inhibitory effects of melatonin on testosterone production are mediated via down-regulation of GATA-4 (zeige GATA4 ELISA Kits) and SF-1 expression.
SF-1 is needed for proper development of fetal and adult Leydig cells but with distinct primary functions
Results clearly indicate that SF-1 is involved in the regulation of LIPE (zeige LIPE ELISA Kits) expression after activation of protein kinase A in adrenocortical cells.
this study identified a novel regulatory circuit for ovarian AMH (zeige AMH ELISA Kits) production; specifically, through the coordinated interplay between FOXL2 (zeige FOXL2 ELISA Kits) and SF-1 (zeige NR5A1 ELISA Kits) that could control ovarian follicle development.
SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA
SF1 (zeige NR5A1 ELISA Kits) was the only specific marker of uterine tumour resembling ovarian sex cord-stromal tumour
rete ovarii were positive for PAX-8 (zeige PAX8 ELISA Kits), weakly positive for SF-1 (zeige NR5A1 ELISA Kits), and negative for PAX-2 (zeige PAX2 ELISA Kits) and GATA-3 (zeige GATA3 ELISA Kits)
A novel function of SF1 (zeige NR5A1 ELISA Kits) in the initial recruitment of the U2 snRNP (zeige LSM2 ELISA Kits) through direct interactions with two U2 snRNP (zeige LSM2 ELISA Kits)-associated proteins.
Data suggest that post-translational processing of SF1 (zeige NR5A1 ELISA Kits) (phosphorylation of Ser20) down-regulates nuclear import of SF1 (zeige NR5A1 ELISA Kits) via alterations in kinetic interaction of SF1 (zeige NR5A1 ELISA Kits) nuclear localization signal (NLS (zeige ALDH1A2 ELISA Kits)) with NLS (zeige ALDH1A2 ELISA Kits) receptor isoforms.
We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65
Gomafu indirectly modulates the function of the splicing factors SF1 (zeige NR5A1 ELISA Kits) and Celf3 (zeige CELF3 ELISA Kits) by sequestering these proteins into separate nuclear bodies.
The conserved SPSP motif phosphorylation and the SF1 (zeige NR5A1 ELISA Kits)/U2AF interface are essential in vivo.
Findings suggest that Zinc finger motif-1 (ZFM1) is an important factor for the stabilization of a contractile SMC (zeige DYM ELISA Kits) phenotype under basal or mildly activating conditions.
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants.
zinc finger protein 162
, splicing factor 1
, splicing factor 1, isoform 1
, adrenal 4-binding protein
, embryonal LTR-binding protein
, embryonal long terminal repeat-binding protein
, fushi tarazu 1 factor homolog
, fushi tarazu factor homolog 1
, steroid hormone receptor Ad4BP
, steroid hydroxylase positive regulator
, steroidogenic factor 1
, mammalian branch point-binding protein
, transcription factor ZFM1
, zinc finger gene in MEN1 locus