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Cow (Bovine) Monoclonal PPARA Primary Antibody für ChIP, FACS - ABIN152696
Sumanasekera, Tien, Turpey, Vanden Heuvel, Perdew: Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. in The Journal of biological chemistry 2003
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Cow (Bovine) Polyclonal PPARA Primary Antibody für ChIP, ELISA - ABIN153509
Selwyn, Cheng, Klaassen, Cui: Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. in Drug metabolism and disposition: the biological fate of chemicals 2016
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Human Monoclonal PPARA Primary Antibody für WB - ABIN1944858
Mukherjee, Jow, Noonan, McDonnell: Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. in The Journal of steroid biochemistry and molecular biology 1995
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Human Polyclonal PPARA Primary Antibody für ICC, IHC (fro) - ABIN3044397
Zhou, Zhang, Xu, Wang: Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. in Journal of pharmacological sciences 2015
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Mouse (Murine) Polyclonal PPARA Primary Antibody für IF, IP - ABIN285918
Suardíaz, Estivill-Torrús, Goicoechea, Bilbao, Rodríguez de Fonseca: Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. in Pain 2007
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Mouse (Murine) Polyclonal PPARA Primary Antibody für IHC, ELISA - ABIN1043876
Plutzky: Medicine. PPARs as therapeutic targets: reverse cardiology? in Science (New York, N.Y.) 2003
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Mouse (Murine) Polyclonal PPARA Primary Antibody für FACS, WB - ABIN656834
Spruiell, Richardson, Cullen, Awumey, Gonzalez, Gyamfi: Role of pregnane X receptor in obesity and glucose homeostasis in male mice. in The Journal of biological chemistry 2014
Mouse (Murine) Polyclonal PPARA Primary Antibody für IHC, ELISA - ABIN105798
Zak, Gelebart, Lai: Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. in Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2010
Human Polyclonal PPARA Primary Antibody für ELISA, WB - ABIN2476186
Yoneda, Lyall, Alsina, Persons, Spada, Levitzki, Zilberstein, Mundy: The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. in Cancer research 1991
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Human Polyclonal PPARA Primary Antibody für IF (p), IHC (p) - ABIN753163
Mölzer, Wallner, Kern, Tosevska, Schwarz, Zadnikar, Doberer, Marculescu, Wagner: Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health. in Scientific reports 2016
These findings suggested that PPARalpha activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA (zeige ARID4B Antikörper) and FFA metabolism.
Hepatic PARP1 (zeige PARP1 Antikörper) activation inhibits FAO pathway upregulation through poly(ADP-ribosyl)ation of PPARalpha, worsening hepatic steatosis and inflammatory responses associated with overnutrition.
TGF-beta (zeige TGFB1 Antikörper) and PPARalpha signaling pathways are involved in radiation-induced heart fibrosis, metabolic dysregulation, and impaired heart contractility, a pathophysiological condition that is often observed in patients that received high radiation doses in thorax.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
findings identify a new important innate immune function for the PPARalpha signaling pathway in regulating intestinal inflammation, mucosal immunity, and commensal homeostasis
our data indicate that PPAR-alpha mediates antimicrobial responses to mycobacterial infection by inducing TFEB (zeige TFEB Antikörper) and lipid catabolism.
adiponectin (zeige ADIPOQ Antikörper) inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (zeige PRKAA1 Antikörper)/PPARalpha/ATF2 (zeige ATF2 Antikörper) pathway.
It was concluded that decreased cardiac PPARalpha expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dietary fat.
these results indicate that PPAR-a accelerates important pathways for the clearance of a-ClFA, and a-ClFA may, in part, accelerate its catabolism by serving as a ligand for PPAR-a
PPARgamma (zeige PPARG Antikörper) controls the cancer stem cell niche
Taken together, our data suggest that eupatilin inhibits TNFalpha (zeige TNF Antikörper)-induced MMP-2 (zeige MMP2 Antikörper)/-9 expression by suppressing NF-kappaB (zeige NFKB1 Antikörper) and MAPKAP-1 (zeige MAPKAP1 Antikörper) pathways via PPARalpha. Our findings suggest the usefulness of eupatilin for preventing skin aging.
Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma (zeige PPARG Antikörper).
Study reports a molecular mechanism by which glucocorticoid-induced PPARalpha expression negatively affects the activity of PPARgamma (zeige PPARG Antikörper) and downregulates BCO1 (zeige BCMO1 Antikörper) gene expression. Results explicate novel aspects of local glucocorticoid:retinoid interactions that may contribute to alveolar tissue remodeling in chronic lung diseases that affect children and, possibly, adults.
Interference with PLIN2 (zeige PLIN2 Antikörper) and PPARalpha resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism.
PPARalpha and FXR (zeige NR1H4 Antikörper) function coordinately to integrate liver energy balance.
An association was found with PPARalpha polymorphism and patients with nicotine dependency and schizophrenia.
PPAR agonists have shown to have anti proliferative effect in squamous cell carcinoma of the head and neck.
Results show that PPARalpha is downregulated and SREBP-1c (zeige SREBF1 Antikörper) is upregulated in steatosis L-02 cells. These changes increase lipid synthesis and reduce lipid disposal, which ultimately lead to hepatic steatosis.
Perfluoroalkyl acids addition to activating PPARalpha as a primary target, also have the potential to activate CAR, PPARgamma (zeige PPARG Antikörper), and ERalpha (zeige ESR1 Antikörper) as well as suppress STAT5B (zeige STAT5B Antikörper).
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (zeige DGAT1 Antikörper) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (zeige ADIPOR1 Antikörper) (SSC10p13) and CREB (zeige CREB1 Antikörper) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (zeige SLC22A5 Antikörper) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (zeige PPARG Antikörper)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (zeige PTGS2 Antikörper) levels in bovine endometrial stromal cells.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
peroxisome proliferator-activated receptor alpha
, ppar alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor-alpha
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, xPPAR alpha