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Rat (Rattus) NR1H4 ELISA Kit für Sandwich ELISA - ABIN432477
Fotschki, Juśkiewicz, Jurgoński, Rigby, Sójka, Kołodziejczyk, Mackie, Zduńczyk: Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet. in The Journal of nutritional biochemistry 2017
we conclude that FXR-Gank (zeige PSMD10 ELISA Kits)-TSPs-Stem cells pathway is a key determinant of liver cancer in animal models and in pediatric liver cancer. Our data provide a strong basis for development of FXR-Gank (zeige PSMD10 ELISA Kits)-based therapy for treatment of patients with hepatoblastoma
PPARalpha (zeige PPARA ELISA Kits) and FXR function coordinately to integrate liver energy balance.
These studies investigated in differentiated HepaRG cells and in primary human hepatocytes (PHHs) effects of FXR activation on HBV replication and of infection on the FXR pathway.
Treatment with LXR (zeige NR1H3 ELISA Kits) and FXR ligands initiates coated platelet formation, which is thought to support coagulation but results in desensitization to platelet stimuli through inhibition of alphaIIbbeta3 consistent with their ability to inhibit platelet function and stable thrombus formation in vivo.
FXR ligands to inhibit platelet activation.
Taken together, our data provide the first evidence that FXR suppresses proliferation of human liver cancer cells via the inhibition of the mTOR (zeige FRAP1 ELISA Kits)/S6K (zeige RPS6KB1 ELISA Kits) signaling pathway. FXR expression can be used as a biomarker of personalized mTOR (zeige FRAP1 ELISA Kits) inhibitor treatment assessment for liver cancer patients.
Activated FXR inhibits leptin (zeige LEP ELISA Kits) signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy.
FXR may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4 (zeige PDK4 ELISA Kits)-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.
this is the first report of bile acid derivatives able to antagonize GPBAR1 (zeige GPBAR1 ELISA Kits) and and farnesoid X receptor (FXR) modulatory activity.
induction of SOCS3 (zeige SOCS3 ELISA Kits) may be a novel mechanism by which FXR exerts its anti-hepatocellular carcinoma effects
results suggest that hypothyroidism induces a moderate non-alcoholic steatohepatitis, alllowing the hepatic regeneration. The FXRalpha may be involved in the development of non-alcoholic steatohepatitis in hypothyroid subjects.
FXR is expressed in the ovary, in all regions of the oviduct, and all portions of the vagina of rabbits.
FXR activation ameliorated central nervous system autoimmunity in an IL-10 (zeige IL10 ELISA Kits)-dependent fashion and even suppressed advanced clinical disease upon therapeutic administration
In livers of mice, FXR regulates amino acid catabolism and detoxification of ammonium via ureagenesis and glutamine synthesis.
Data suggest that FXR and TGR5 (zeige GPBAR1 ELISA Kits) expression is down-regulated in aging kidney; caloric restriction prevents these age-related changes. Additionally, in long-lived Ames dwarf (zeige PROP1 ELISA Kits) mice, renal FXR and TGR5 (zeige GPBAR1 ELISA Kits) expression is up-regulated. Treatment of aged mice with dual FXR/TGR5 (zeige GPBAR1 ELISA Kits) agonist reverses age-related changes in kidney structure/function. (FXR = farnesoid X activated receptor; TGR5 (zeige GPBAR1 ELISA Kits) = G protein-coupled bile acid receptor 1 (zeige GPBAR1 ELISA Kits))
this study provides evidence for roles of FXR as an important regulator of placental inflammation
These findings suggest that bile acids and FXR play pivotal roles in sepsis via controlling the NLRP3 (zeige NLRP3 ELISA Kits) inflammasome.
Our results indicate that the gut (zeige GUSB ELISA Kits) microbiota promotes diet-induced obesity and associated phenotypes through FXR, and that FXR may contribute to increased adiposity by altering the microbiota composition.
findings uncovered a novel mechanism in which INT-767 activation of FXR induces Tgr5 (zeige GPBAR1 ELISA Kits) gene expression and increases Ca(2 (zeige CA2 ELISA Kits)+) levels and cAMP activity to stimulate GLP-1 (zeige GCG ELISA Kits) secretion and improve hepatic glucose and lipid metabolism in high-fat diet-induced obese mice.
In mice, we found transintestinal cholesterol excretion to be regulated by intestinal FXR via induction of its target gene Fgf15.
FXR could be a target molecule for reducing portal hypertension during hepatic fibrosis.
alterations in bile acid composition may have contributed to the observed disturbance in FXR-mediated signalling pathways in short bowel syndrome-associated liver disease
FXR splice variant has a dominant positive effect on wild type FXR.
In conclusion, PXR (zeige NR1I2 ELISA Kits) and FXR both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR (zeige NR1I2 ELISA Kits) and FXR transactivation at in vivo expression levels.
This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
nuclear receptor subfamily 1, group H, member 4
, orphan nuclear receptor FOR2
, bile acid receptor
, farnesoid X activated receptor
, bile acid receptor-like
, RXR-interacting protein 14
, farnesoid X nuclear receptor
, farnesoid X-activated receptor
, farnesol receptor HRR-1
, retinoid X receptor-interacting protein 14
, nuclear receptor subfamily 1 group H member 4