Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Data show that phosphorylated forms of nucleophosmin 1 (NPM1 (zeige NPM1 Proteine)) interact with androgen receptor (AR) in nucleoplasm.
We show AR expressed in cancer-associated fibroblasts (CAFs) contributes to the tumor-promoting abilities that CAFs exert on epithelial prostate cancer cells. Further, we found that decreased AR expression in CAFs is also associated with an increase in stem cell marker gene expression in prostate cancer epithelial cells.
Within an institutional cohort, the RNA ISH (zeige ANTXR2 Proteine) assay identified AR-V7 within FFPE tissue and may have prognostic value in metastatic castration-sensitive prostate cancer. These preliminary findings warrant further study in larger cohorts.
increases hematogenous metastasis (zeige MOK Proteine)yet decreases lymphatic metastasis of renal cell carcinoma through differential regulation of VEGF-A vs. VEGF-C via miR-185-5p
Data show that enzalutamide resistance was accompanied by increased androgen receptor (AR) mRNA and protein expression as well as AR gene amplification.
Lipocalin 2 (zeige LCN2 Proteine) could facilitate proliferation of castration-resistant prostate cancer cells by activating androgen receptor transcriptional activity.
Tumor cell clusters were more prevalent and bigger in bone marrow aspirates than in blood, expressed higher levels of the androgen receptor protein per tumor cell, and were prognostic in metastatic castration-resistant prostate cancer
Plasma androgen receptor mutational status assessment identifies castration-resistant prostate cancer patients with worse outcome to enzalutamide or abiraterone.
In a 46,XY phenotypically female patient bearing testes in inguinal canal, and diagnosed with complete androgen insensitivity syndrome, the dysfunctioning of AR by mutation enhanced AMH (zeige AMH Proteine) expression which ultimately leads to the failure in maturation of Sertoli cells.
increased Snail (zeige SNAI1 Proteine) expression during progression to metastatic disease may prime cells for resistance to AR-targeted therapies by promoting AR activity in prostate cancer
in clear cell renal cell carcinoma (zeige MOK Proteine), enhances lung and liver metastases, while suppressing lymphatic metastasis
Glandular epithelial AR inactivation (with persistent stromal AR action) enhanced PTEN deletion-induced uterine pathology possibly by downregulating progesterone receptor (zeige PGR Proteine) expression in the uterus.
CDK2 (zeige CDK2 Proteine) phosphorylates polyQ-AR specifically at Ser (zeige SIGLEC1 Proteine)(96). Phosphorylation of polyQ-AR by CDK2 (zeige CDK2 Proteine) increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.
experimental manipulation of the prenatal androgen level, by blocking the androgen receptor with flutamide or activating the androgen receptor with dihydrotestosterone (DHT), leads to changes in the length of the fingers of all paws in males and females.
Silencing of androgen receptor rescues the muscular spinal atrophy transgenic mice.
Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
Prostate 5aR1 levels were positively correlated with adjusted prostate most severe lesion scores. Downregulation of androgen receptor and 5alpha-reductase 2, along with upregulation of 5a-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP (zeige DPT Proteine) mice
Bisphenol A inhibits Sertoli cell proliferation by interfering with androgen receptor signaling pathway.
Findings indicate that targeting androgen receptor (AR) with ASC (zeige STS Proteine)-J9 in experimental autoimmune myocarditis (EAM) resulted in an attenuation in the severity of disease and cardiac injury.
substantial up-regulation of androgen receptor expression during trophoblast giant cell differentiation suggests that androgens may be related to this process and are active products of bovine placental steroidogenesis
no association between the AR CAG polymorphism and the relative risk of prostate cancer in white Brazilian individuals with a CAG repeat (zeige CELF3 Proteine)
FSHR (zeige FSHR Proteine) is specifically regulated through androgen receptor in granulosa cells
Roles of IGF-I (zeige IGF1 Proteine) and the estrogen, androgen and IGF-I (zeige IGF1 Proteine) receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
In GD20 and PD2 (zeige PAF1 Proteine) males we found the reduction of the luminal compartment, inflammatory changes, decreased androgen receptor and increased Cx43 (zeige GJA1 Proteine) expression
Data suggest that signal transduction involving androgen receptor is involved in apoptosis of granulosa cells (as seen in follicular atresia).
Pig ejaculated spermatozoa express androgen receptor.
Androgen receptor (AR) and Wilms' tumor gene 1 expression dramatically decreased after heat treatment in Sertoli cells
Sertoli cell maturation during puberty in the stallion was accompanied by a reduced expression of anti-Mullerian hormone (zeige AMH Proteine) and its receptor, arrest of cell proliferation, increased expression of androgen receptor
The vesicular gland of castrated goats showed significantly lower AR and COX-2 immuno-expression than intact goats indicating that both AR and COX-2 are androgen dependent.
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
androgen nuclear receptor variant 2
, dihydrotestosterone receptor
, nuclear receptor subfamily 3 group C member 4
, testicular feminization
, androgen receptor (Testicular feminization), same as Tfm
, androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)
, androgen receptor AR
, Ar beta
, androgen receptor
, prostate androgen receptor