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The present studies aim to examine whether and how cilia function (Pkd1 (zeige PKD1 Proteine) or Pkd2 (zeige PKD2 Proteine)) and structure (Tg737 (zeige IFT88 Proteine)) play a role in cystic kidney and aneurysm through survivin downregulation.
Survivin 1 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
the Aurora B (zeige AURKB Proteine) chromosome passenger protein complex, including INCENP (zeige INCENP Proteine) and survivin, is regulated during oocyte maturation in Xenopus laevis
HDL (zeige HSD11B1 Proteine)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (zeige STAT3 Proteine) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (zeige PARP1 Proteine) activation and inhibits TNFalpha (zeige TNF Proteine)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (zeige TGFB1 Proteine) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (zeige GUSB Proteine) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (zeige WNT2 Proteine) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) cancer stem cell formation and cancer SCC (zeige CYP11A1 Proteine) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (zeige BCL2 Proteine) and ki67 (zeige MKI67 Proteine).
survivin is essential for B cell division but does not affect survival of naive B cells. Survival of proliferating B cells may be impacted indirectly by survivin deficiency because of increased genotoxic stress caused by failed chromosomal segregation.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate.
baculoviral IAP repeat-containing protein 5
, survivin 1
, baculoviral IAP repeat-containing protein 5.1
, Survivin 2
, baculoviral IAP repeat-containing 5, gene 2
, baculoviral IAP repeat-containing protein 5.2
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5 (survivin)
, apoptosis inhibitor 4