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ablation of Glut1 (zeige SLC2A1 Proteine) attenuated apoptosis and increased drug resistance via upregulation of p-Akt (zeige AKT1 Proteine)/p-GSK-3beta (Ser9)/beta-catenin (zeige CTNNB1 Proteine)/survivin.
Nuclear survivin expression correlates with endoglin (zeige ENG Proteine)-assessed microvascularisation in laryngeal squamous cell carcinoma.
survivin expression modes and YAP (zeige YAP1 Proteine) localization (Hippo pathway activation modes) were not correlated with survival. In addition, we confirmed that survivin small interference RNA (siRNA) transfection and YM155, an anti-survivin drug, elicited decreased nuclear survivin expression and cell proliferation in ISO-HAS-B cells which expressed survivin consistently
Survivin expression in lung squamous cell carcinoma was increased compared to normal tissue, and was unaffected by methylation status of the surviving gene.
Survivin gene promoter methylation was more frequent in gastric cancer patients than in controls.
These findings uncover the significance of Merlin (zeige NF2 Proteine) protein expression and Survivin labeling index as prognosticators for poor clinical outcome in two independent Malignant pleural mesothelioma cohorts.
circulating Survivin in prostate cancer patients was higher compared to controls, with the highest levels in African-American (AA) patients. AA patients with prostate cancer contained higher amounts of extracellular vesicles (EVs) in their plasma and sera than European-American (EA) patients. EVs from AA patients with prostate cancer contained higher amounts of Survivin, XIAP (zeige XIAP Proteine) and cIAP-2 (zeige BIRC3 Proteine) than EVs from EA patients.
results indicate that survivin is of prognostic signi fi cance in patients with renal cell carcinoma (zeige MOK Proteine)
The aim of this study was to compare the prognostic value of the histopathological grading and the conventional biomarker MIB-1 with expression of the anti-apoptotic protein survivin to see if this biomarker could complement recurrence prediction.
Data suggest that the first 22 bp of exon 3 in BIRC5 contain cis (zeige CISH Proteine)-acting elements that enhance the exclusion of exon 3 to generate the survivin DEx3 mRNA isoform via exclusion/deletion of exon 3; Sam68 (zeige KHDRBS1 Proteine) is a possible trans-acting factor that binds to this cis (zeige CISH Proteine)-acting element and regulates exon 3 splicing. (BIRC5/survivin = baculoviral IAP repeat containing 5; Sam68 (zeige KHDRBS1 Proteine) = GAP-associated tyrosine phosphoprotein p62 (zeige KHDRBS1 Proteine))
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (zeige HSD11B1 Proteine)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (zeige STAT3 Proteine) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (zeige PARP1 Proteine) activation and inhibits TNFalpha (zeige TNF Proteine)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (zeige TGFB1 Proteine) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (zeige GUSB Proteine) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (zeige WNT2 Proteine) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) cancer stem cell formation and cancer SCC (zeige CYP11A1 Proteine) development.
In colorectal cancer mice with downregulated expression of survivin, there were higher numbers of apoptotic cells and decreased expression levels of bcl2 (zeige BCL2 Proteine) and ki67 (zeige MKI67 Proteine).
The present studies aim to examine whether and how cilia function (Pkd1 (zeige PKD1 Proteine) or Pkd2 (zeige PKD2 Proteine)) and structure (Tg737 (zeige IFT88 Proteine)) play a role in cystic kidney and aneurysm through survivin downregulation.
Survivin 1 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
the Aurora B (zeige AURKB Proteine) chromosome passenger protein complex, including INCENP (zeige INCENP Proteine) and survivin, is regulated during oocyte maturation in Xenopus laevis
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)
, apoptosis inhibitor 4
, survivin variant 3 alpha
, survivin 1
, baculoviral IAP repeat-containing protein 5.1
, Survivin 2
, baculoviral IAP repeat-containing 5, gene 2
, baculoviral IAP repeat-containing protein 5.2