anti-RBPJ (RBPJ) Antikörper

Bezeichnung:
anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region Antikörper (RBPJ)
Auf www.antikoerper-online.de finden Sie aktuell 86 Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) Antikörper von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen RBPJ Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 100 RBPJ Produkte verfügbar.
Synonyme:
AI843960, AOS3, CBF1, csl, Igkjrb, IGKJRB1, Igkrsbp, KBF2, RBP-J, RBP-J kappa, RBPjk, Rbpsuh, Su(H), SUH, XSu(H), xsu(h)1

Meistgesuchte Reaktivitäten zu anti-RBPJ (RBPJ) Antikörper

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anti-Rat (Rattus) RBPJ Antikörper:

anti-Human RBPJ Antikörper:

anti-Mouse (Murine) RBPJ Antikörper:

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Am meisten referenzierte anti-RBPJ Antikörper

  1. Cow (Bovine) Polyclonal RBPJ Primary Antibody für IP, IHC - ABIN2777213 : MacKenzie, Duriez, Larrivée, Chang, Pollet, Wong, Yip, Karsan: Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa. in Blood 2004 (PubMed)

  2. Human Monoclonal RBPJ Primary Antibody für ChIP, EMSA - ABIN2668822 : Ehm, Göritz, Covic, Schäffner, Schwarz, Karaca, Kempkes, Kremmer, Pfrieger, Espinosa, Bigas, Giachino, Taylor, Frisén, Lie: RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)

  3. Human Monoclonal RBPJ Primary Antibody für WB - ABIN2668739 : Maier, Santak, Mantik, Grabusic, Kremmer, Hammerschmidt, Kempkes et al.: A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 ... in Journal of virology 2005 (PubMed)

Weitere Antikörper gegen RBPJ Interaktionspartner

Human Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) Interaktionspartner

  1. Mean CBF1 expression is significantly increased in isocitrate dehydrogenase 1 (IDH1 (zeige IDH1 Antikörper)) R132H mutant glioblastoma. Hypoxic regions of glioblastoma have higher CBF1 activation and exposure to low oxygen can induce its expression in glioma cells in vitro.

  2. structural and biophysical studies demonstrate that RITA (zeige ZNF331 Antikörper) binds RBP-J similarly to the RAM (zeige RAB27A Antikörper) (RBP-J-associated molecule) domain of Notch (zeige NOTCH1 Antikörper), our biochemical and cellular assays suggest that RITA (zeige ZNF331 Antikörper) interacts with additional regions in RBP-J.

  3. The present findings indicate that p53 (zeige TP53 Antikörper), in turn, decreases CSL (zeige CSHL1 Antikörper) expression, which can serve to enhance p53 (zeige TP53 Antikörper) activity in acute DNA damage response of cells.

  4. RBP-J mediated by miR (zeige MLXIP Antikörper)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  5. These results suggest that PSK (zeige TAOK2 Antikörper) suppresses Hedgehog (zeige SHH Antikörper) signaling through down-regulation of MAML3 (zeige MAML3 Antikörper) and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK (zeige TAOK2 Antikörper) as a Hedgehog (zeige SHH Antikörper) inhibitor

  6. our findings reconcile the 2 biological events and point to a multistep process of CAF (zeige KAT2B Antikörper) activation under convergent CSL (zeige CSHL1 Antikörper) and p53 (zeige TP53 Antikörper) control. Activation of p53 (zeige TP53 Antikörper) provides a failsafe mechanism against consequences of compromised CSL (zeige CSHL1 Antikörper) activity in stromal cells.

  7. RBPJ polymorphism [rs874040(CC) allele] skews memory T cells toward a pro-inflammatory phenotype involving Notch (zeige NOTCH1 Antikörper) signaling, thus increasing the susceptibility to develop rheumatoid arthritis.

  8. The role of CSL (zeige CSHL1 Antikörper)-dependent and independent Notch (zeige NOTCH1 Antikörper) signaling pathways in cell apoptosis is described in normal tissue homeostasis and in tumorigenesis. (Review)

  9. These results support a model in which EBNA2 and EBNA3s compete for distinct subsets of RBPJ sites to regulate cell genes and where EBNA3 (zeige EBNA-3A Antikörper) subset specificity is determined by interactions with other cell transcription factors.

  10. Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 (zeige MAML3 Antikörper) and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer.

Xenopus laevis Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) Interaktionspartner

  1. findings reveal that, in response to Wnt (zeige WNT2 Antikörper) signalling, Dishevelled (zeige DVL2 Antikörper) inhibits CSL (zeige SMPX Antikörper) transcription factors to regulate Notch (zeige NOTCH1 Antikörper) signalling and cell-fate decisions in vivo

  2. The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52 (zeige C12orf52 Antikörper)) as a novel rbpj/CBF-1-interacting protein.

  3. The results suggest that a cell-to-cell interaction via the Notch (zeige NOTCH1 Antikörper)/Su(H) pathway has a significant role in the PGC (zeige PGC Antikörper) migration by regulating cell motility.

  4. This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H) mRNA.

Mouse (Murine) Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ) Interaktionspartner

  1. RBP-J-mediated Notch (zeige NOTCH1 Antikörper) signalling is critical for basophil-dependent immunoregulation. Deficiency of RBP-J influences the immunoregulatory functions of BA, which include activation of T cells and their differentiation into T helper cell subtypes.

  2. Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (zeige MBD4 Antikörper) plays role in enamel formation; Med1 (zeige MBD4 Antikörper) induces Alpl (zeige ALPL Antikörper) via stimulation of Notch1 (zeige NOTCH1 Antikörper) signaling by forming Notch1 (zeige NOTCH1 Antikörper)-RBP-Jk complex on Alpl (zeige ALPL Antikörper) promoter. (Med1 (zeige MBD4 Antikörper) = mediator complex subunit 1 (zeige MED1 Antikörper); Alpl (zeige ALPL Antikörper) = alkaline phosphatase, liver-bone-kidney; Notch1 (zeige NOTCH1 Antikörper) = Notch gene homolog 1 (zeige NOTCH1 Antikörper); RBP-Jk = kappa J region recombining binding protein suppressor of hairless)

  3. study uncovered a regulatory network, where miR (zeige MLXIP Antikörper)-182 functions as an important new node that receives inputs from RBP-J and TNF-alpha (zeige TNF Antikörper) signaling and positively regulates inflammatory osteoclastogenesis; suppression of miR (zeige MLXIP Antikörper)-182 by RBP-J serves as an important mechanism that restrains TNF-alpha (zeige TNF Antikörper) induced osteoclastogenesis

  4. structural and biophysical studies demonstrate that RITA (zeige C12orf52 Antikörper) binds RBP-J similarly to the RAM (zeige FAM103A1 Antikörper) (RBP-J-associated molecule) domain of Notch (zeige NOTCH1 Antikörper), our biochemical and cellular assays suggest that RITA (zeige C12orf52 Antikörper) interacts with additional regions in RBP-J.

  5. Intronic Flk1 (zeige KDR Antikörper) genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.

  6. RBP-J mediated by miR (zeige MLXIP Antikörper)-133a probably contributed to the regulation of DCs maturation and activation in osteosarcoma

  7. Rbpj-kappa mediated Notch (zeige NOTCH1 Antikörper) signaling plays a critical role in development of hypothalamic Kisspeptin neurons.

  8. Results reveal an essential role for canonical Notch (zeige NOTCH1 Antikörper)/RBP-J signaling in hippocampal synaptic plasticity and suggest that role, at least in part, is mediated by the regulation of GABAergic signaling

  9. The bone marrow contains a progenitor that expresses renin (zeige REN Antikörper) throughout development and possesses a B-lymphocyte (zeige AKAP17A Antikörper) pedigree. This cell requires RBP-J to differentiate.

  10. functions as a transcriptional repressor on the promoter of the microRNA miR (zeige MLXIP Antikörper)-155

RBPJ Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.

Alternative names and synonyms associated with RBPJ

  • recombination signal binding protein for immunoglobulin kappa J region (Rbpj) Antikörper
  • recombination signal binding protein for immunoglobulin kappa J region (RBPJ) Antikörper
  • recombination signal binding protein for immunoglobulin kappa J region (rbpj) Antikörper
  • AI843960 Antikörper
  • AOS3 Antikörper
  • CBF1 Antikörper
  • csl Antikörper
  • Igkjrb Antikörper
  • IGKJRB1 Antikörper
  • Igkrsbp Antikörper
  • KBF2 Antikörper
  • RBP-J Antikörper
  • RBP-J kappa Antikörper
  • RBPjk Antikörper
  • Rbpsuh Antikörper
  • Su(H) Antikörper
  • SUH Antikörper
  • XSu(H) Antikörper
  • xsu(h)1 Antikörper

Bezeichner auf Proteinebene für RBPJ

recombining binding protein suppressor of hairless , CBF-1 , H-2K binding factor-2 , RBP-J kappa , RBP-JK , immunoglobulin kappa J region recombination signal binding protein 1 , renal carcinoma antigen NY-REN-30 , suppressor of hairless homolog , X-Su(H) , suppressor of hairless protein 1 , suppressor of hairless protein homolog , J kappa-recombination signal-binding protein

GENE ID SPEZIES
679028 Rattus norvegicus
3516 Homo sapiens
399453 Xenopus laevis
19664 Mus musculus
767928 Bos taurus
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