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These data demonstrated fascin (zeige FSCN1 ELISA Kits) as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch (zeige NOTCH1 ELISA Kits) self-renewal signaling pathway.
Examination of the molecular underpinnings of this "NOTCH2-BCR (zeige BCR ELISA Kits) axis" in cGVHD revealed imbalanced expression of the transcription factors IRF4 (zeige IRF4 ELISA Kits) and IRF8 (zeige IRF8 ELISA Kits), each critical to B (zeige TDO2 ELISA Kits)-cell differentiation and fate. All-trans retinoic acid (ATRA) increased IRF4 (zeige IRF4 ELISA Kits) expression, restored the IRF4 (zeige IRF4 ELISA Kits)-to-IRF8 (zeige IRF8 ELISA Kits) ratio, abrogated BCR (zeige BCR ELISA Kits)-NOTCH (zeige NOTCH1 ELISA Kits) hyperactivation, and reduced NOTCH2 expression in cGVHD B cells without compromising viability.
Genetic variation in NOTCH2 was associated with troponin T levels in women with psychosis.
miR (zeige MLXIP ELISA Kits)-34a expression is silenced epigenetically by EZH2 (zeige EZH2 ELISA Kits) and DNA methylation (zeige HELLS ELISA Kits), which promotes cholangiocarcinoma cell growth through activation of the Notch (zeige NOTCH1 ELISA Kits) pathway.
Human biliary atresia and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC (zeige DDC ELISA Kits))-induced experimental cholestasis in mice are associated with increased expression of Notch2.
In conclusion, Notch (zeige NOTCH1 ELISA Kits) siganling appears to be an important mediator of the liver inflammation by modulating hepatic IL-22 (zeige IL22 ELISA Kits)-secreting NKp46 (zeige NCR1 ELISA Kits)(+) innate lymphoid cells.
The data showed that the overexpression of miR (zeige MLXIP ELISA Kits)-18a-5p could downregulate Notch2 expression and subsequently suppress endothelial-mesenchymal transition and cardiac fibrosis.
Major genomic mutation profiles in lacrimal gland adenoid cystic carcinoma (LGACC) were uncovered by exome-seq. Although preliminary in nature, the Notch (zeige NOTCH1 ELISA Kits) pathway could be a potential therapeutic target for LGACC.
Data indicate that mRNA high expression level of Notch1 (zeige NOTCH1 ELISA Kits) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (zeige CYP11A1 ELISA Kits)), HR, and mRNA high expression levels of Notch2 and Notch3 (zeige NOTCH3 ELISA Kits) were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 (zeige NOTCH4 ELISA Kits) was not found to be associated with to OS for all NSCLC.
Mutation in NOTCH2 gene is associated with nodal marginal zone lymphoma.
Notch2 physiologically regulates bone remodeling by inhibiting trabecular bone formation in the appendicular skeleton.
Notch2 was crucial in maintaining the integrity of the epithelial and smooth muscle layers of the distal conducting airways, and our data suggest that epithelial Notch (zeige NOTCH1 ELISA Kits) signaling regulates multiple aspects of postnatal development in the distal lung and may represent a potential target for intervention in pulmonary diseases.
Authors confirmed that NOTCH2 is significantly over-expressed in EEA. In the most relevant endometrial adenocarcinoma cell model, Ishikawa H, altering miR (zeige MLXIP ELISA Kits)-181c expression produces significant changes in NOTCH2 expression, consistent with direct targeting.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (zeige HLCS ELISA Kits)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7 (zeige FBXW7 ELISA Kits)/NOTCH2 pathway as observed in patients with HCS (zeige HLCS ELISA Kits).
Hajdu-Cheney Syndrome is a devastating disease associated with a gain-of-NOTCH2 function resulting in diverse clinical manifestations
Lnc-LFAR1 binds directly to Smad2 (zeige SMAD2 ELISA Kits)/3 and promotes transcription of TGFbeta (zeige TGFB1 ELISA Kits), Smad2 (zeige SMAD2 ELISA Kits), Smad3 (zeige SMAD3 ELISA Kits), Notch2 and Notch3 (zeige NOTCH3 ELISA Kits) which, in turn, results in TGFbeta (zeige TGFB1 ELISA Kits) and Notch (zeige NOTCH1 ELISA Kits) pathway activation.
Study indicates that knockdown of Notch2 promotes in vivo growth of triple-negative breast cancer (TNBC) and proposes that Notch2 functions as a tumor growth suppressor in TNBC.
this study shows that Notch (zeige NOTCH1 ELISA Kits) signaling regulates basophils biological function, at least partially via the modulation of MAPK (zeige MAPK1 ELISA Kits)
Postnatal development analysis revealed that in cilia-deficient corneal epithelial cells downregulation of the Notch (zeige NOTCH1 ELISA Kits) pathway precedes cell proliferation defects.
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 (zeige NOTCH1 ELISA Kits) and Notch3 (zeige NOTCH3 ELISA Kits), suggesting that ORF2 interfered with the trans-activation potential of Notch (zeige NOTCH1 ELISA Kits).
DeltaC/Notch1a and Notch2 signaling is responsible for a survival signal provided by xanthophores to melanophores.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
, neurogenic locus notch homolog protein 2-like
, Notch homolog 2
, neurogenic locus notch homolog protein 2
, Motch B
, Notch gene homolog 2
, notch gene homolog 2
, notch receptor protein 6