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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Box inhibit NICD1 degradation and that the N1-Box is transferable for the promotion of degradation of heterologous pro
ten candidate variants were prioritised. Of these, SRPK2 (zeige SRPK2 Proteine) (c.2044C>T[p.Arg682Trp]) and NOTCH1 (c.3835C>T[p.Arg1279Cys]), co-segregated with disease in the family; however, previous functional analyses on SRPK2 (zeige SRPK2 Proteine) make this an unlikely candidate. Functional analyses in the variant (c.3835C>T[p.Arg1279Cys]) of the known CHD (zeige CHDH Proteine) gene NOTCH1 demonstrated a non-significant decrease in signalling activity.
NOTCH1 inhibits activation of ATM (zeige ATM Proteine) by impairing the formation of an ATM (zeige ATM Proteine)-FOXO3a (zeige FOXO3 Proteine)-KAT5 (zeige KAT5 Proteine) complex.
Data demonstrate the possible involvement of Notch1 signaling in the pathogenesis and development of endometriosis, via regulating proliferation and migration of endometrial epithelial and stromal stem cells.
Studies suggest that embryonic signaling pathways, the likes of Notch, Wnt (zeige WNT2 Proteine), and Hedgehog (zeige SHH Proteine) and tumor marker Oct-4 (zeige POU5F1 Proteine) offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth.
Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer.
RBPJ (zeige RBPJ Proteine) interacts with L3MBTL3 (zeige L3MBTL3 Proteine) to promote repression of Notch signaling via histone demethylase (zeige MBD2 Proteine) KDM1A (zeige KDM1A Proteine).
Notch1/Snail1 (zeige SNAI1 Proteine)/E-cadherin (zeige CDH1 Proteine) pathway facilitates the EMT (zeige ITK Proteine) through HIF-1alpha (zeige HIF1A Proteine) in SRA01/04 cells during hypoxia and promotes LEC motility.
Data suggest that activation of Notch1 signaling inhibits apoptosis of dental follicle stem cells via both canonical mitochondrial pathway and non-canonical Akt (zeige AKT1 Proteine) signaling pathway (which is dependent on intracellular domain of Notch1), together with regulation of nuclear gene expression (repression of p53 (zeige TP53 Proteine) gene expression).
Data indicate that jagged 1 (zeige JAG1 Proteine) protein (JAG1 (zeige JAG1 Proteine))-mediated Notch signaling regulates differentiation of basal cells (BC) into secretory cells.
Treatment with antibodies targeting VCAM1 (zeige VCAM1 Proteine) or Notch receptors prevented NICD-mediated lung colonization; further, anti-VCAM1 (zeige VCAM1 Proteine) also significantly reduced neutrophil infiltration.Targeting endothelial cell Notch1 signaling or VCAM1 (zeige VCAM1 Proteine) may be a potential therapeutic strategy.
Induction of autophagy required ligand-dependent, Notch intracellular domain (NIC (zeige NCSTN Proteine)) activity, which controlled mitochondrial organization and survival of activated Tregs.
Our data demonstrate the role of endothelial Notch1 in the proper development of the semilunar valves and cardiac outflow tract.
BLOS2 (zeige BLOC1S2 Proteine) physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 (zeige BLOC1S2 Proteine) is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.
pre-coated Notch1 protein promotes Notch1-knocked down B cells to produce antibody in LPS (zeige TLR4 Proteine)-stimulated B cells suggesting that Notch1 in other cells may promote antibody production by binding its ligands Dll1 (zeige DLL1 Proteine) and Jag1 (zeige JAG1 Proteine) in B cells.
behavioral and functional studies demonstrated that POMC (zeige POMC Proteine)-Notch1(-/-) mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Notch1 haploinsufficiency decreased the expression of Ctgf (zeige CTGF Proteine) in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 intracellular domain (NICD) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1, not Notch3 (zeige NOTCH3 Proteine), directly modulates the expression of CTGF (zeige CTGF Proteine)
Notch signaling has roles in distinct aspects of prostate cancer biology, promoting metastasis in a prostate-specific Pten-null mouse model
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (zeige SHH Proteine) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (zeige MMP11 Proteine) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (zeige HES5 Proteine) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (zeige RBPJ Proteine)) pathway has a significant role in the PGC (zeige PGC Proteine) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (zeige BCL6 Proteine) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (zeige MAML1 Proteine)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (zeige SMAD2 Proteine) nuclear localization and the competence of ectodermal cells for activin A (zeige INHBA Proteine) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (zeige NOTCH3 Proteine), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog