Notch1 Proteine (NOTCH1)

Bezeichnung:
Notch 1 Proteine (NOTCH1)
Auf www.antikoerper-online.de finden Sie aktuell 12 Notch 1 (NOTCH1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Notch1 Antikörper (389) und Notch1 Kits (22) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 436 Notch1 Produkte verfügbar.
Synonyme:
9930111A19Rik, hN1, lin-12, Mis6, N1, NOTCH, notch-1, NOTCH1, notch1-a, Tan1, xnotch, xnotch1, Xotch
alle Proteine anzeigen Gen GeneID UniProt
NOTCH1 4851 P46531
NOTCH1 18128 Q01705
Ratte NOTCH1 NOTCH1 25496  

Weitere Synonyme anzeigen

Notch1 Proteine (NOTCH1) nach Spezies

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Am meisten referenzierte Notch1 Proteine

  1. Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230 : Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009 (PubMed)

Weitere Proteine zu Notch1 Interaktionspartnern

Human Notch 1 (NOTCH1) Interaktionspartner

  1. In conclusion, Notch siganling appears to be an important mediator of the liver inflammation by modulating hepatic IL-22 (zeige IL22 Proteine)-secreting NKp46 (zeige NCR1 Proteine)(+) innate lymphoid cells.

  2. High Notch1 expression is associated with basal-like breast cancer.

  3. High NOTCH1 expression is associated with T-cell leukemia.

  4. this is the first report of a NOTCH1 mutation associated with familial cases of a single ventricle defect

  5. High NOTCH1 expression is associated with ovarian cancer.

  6. These data suggest that a key pathomechanism for this novel form of muscular dystrophy with POGLUT1 (zeige POGLUT1 Proteine) mutation is Notch-dependent loss of satellite cells.

  7. Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice with shortened telomeres were concordant with proosteoblast and proinflammatory gene network alterations

  8. The PROX1 (zeige PROX1 Proteine)/KLF2 (zeige KLF2 Proteine) complex upregulates the expression of DTX1 (zeige DTX1 Proteine) and DTX3L (zeige DTX3L Proteine). DTX1 (zeige DTX1 Proteine) and DTX3L (zeige DTX3L Proteine), functioning as a heterodimeric Notch E3 ligase, concertedly downregulate NOTCH1 activity and enhance lymphatic sprouting

  9. Taken together, our data demonstrate that JNK (zeige MAPK8 Proteine) regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 signaling via activation of c-Jun (zeige JUN Proteine) and indicate that JNK/c-Jun/Notch1 signaling is a potential therapeutic target for TNBC

  10. Studied the correlation between histone acetylation and Notch1 expression in lung carcinoma; results show a significant correlation between the level of acetylation of histone H3 (zeige HIST3H3 Proteine) surrounding the promoter region of Notch1, and expression of Notch1 in human lung cancer cell lines.

Mouse (Murine) Notch 1 (NOTCH1) Interaktionspartner

  1. Dll4 (zeige DLL4 Proteine)-Notch1 signalling couples sprouting angiogenesis and artery formation.

  2. Genes that were dysregulated due to NOTCH1 haploinsufficiency in mice with shortened telomeres were concordant with proosteoblast and proinflammatory gene network alterations

  3. this study shows that Notch signaling regulates basophils biological function, at least partially via the modulation of MAPK (zeige MAPK1 Proteine)

  4. The PROX1 (zeige C16orf35 Proteine)/KLF2 (zeige KLF2 Proteine) complex upregulates the expression of DTX1 (zeige DTX1 Proteine) and DTX3L (zeige DTX3L Proteine). DTX1 (zeige DTX1 Proteine) and DTX3L (zeige DTX3L Proteine), functioning as a heterodimeric Notch E3 ligase, concertedly downregulate NOTCH1 activity and enhance lymphatic sprouting

  5. Postnatal development analysis revealed that in cilia-deficient corneal epithelial cells downregulation of the Notch pathway precedes cell proliferation defects.

  6. a2V deficiency disrupts the endolysosomal route in Notch and TGF signaling, thereby impairing mammary gland development.

  7. ACTG2 (zeige ACTG2 Proteine) boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner.

  8. The results have unraveled a novel molecular pathway driven by interactions between prion protein (PrP (zeige PRNP Proteine)) and Notch1 in the progression of pancreatic ductal adenocarcinoma (PDAC), supporting a critical tumor-promoting role of Notch1 in PrP-expressing PDAC tumors.

  9. these results show that ADAM10 (zeige ADAM10 Proteine)-Notch signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.

  10. Notch1 and Notch2 (zeige NOTCH2 Proteine) are the primary Notch receptors regulating epithelial cell homoeostasis in mouse and human stomach.

Xenopus laevis Notch 1 (NOTCH1) Interaktionspartner

  1. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

  2. Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (zeige SHH Proteine) expression in the midline.

  3. Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (zeige MMP11 Proteine) gene or the constitutively active form of Notch (IC).

  4. ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (zeige HES5 Proteine) gene expression.

  5. results suggest that a cell-to-cell interaction via the Notch/Su(H (zeige RBPJ Proteine)) pathway has a significant role in the PGC (zeige PGC Proteine) migration by regulating cell motility

  6. the process of delimiting the three germ layers requires Notch signaling.

  7. BCL6 (zeige BCL6 Proteine) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (zeige MAML1 Proteine)) from binding.

  8. the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis

  9. Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.

  10. Notch controls smad2 (zeige SMAD2 Proteine) nuclear localization and the competence of ectodermal cells for activin A (zeige INHBA Proteine) in Xenopus embryos

Cow (Bovine) Notch 1 (NOTCH1) Interaktionspartner

  1. the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height

  2. bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (zeige NOTCH3 Proteine), suggesting that ORF2 interfered with the trans-activation potential of Notch.

  3. Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.

Notch1 (NOTCH1) Protein Überblick

Protein Überblick

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

Alternative names and synonyms associated with Notch1 (NOTCH1)

  • notch 1 (notch1)
  • notch 1 (NOTCH1)
  • Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
  • Notch homolog 1, translocation-associated (NOTCH1)
  • notch 1 (Notch1)
  • 9930111A19Rik Protein
  • hN1 Protein
  • lin-12 Protein
  • Mis6 Protein
  • N1 Protein
  • NOTCH Protein
  • notch-1 Protein
  • NOTCH1 Protein
  • notch1-a Protein
  • Tan1 Protein
  • xnotch Protein
  • xnotch1 Protein
  • Xotch Protein

Bezeichner auf Proteinebene für Notch 1 Proteine (NOTCH1)

notch 1 , Notch homolog 1, translocation-associated (Drosophila) , Notch homolog 1, translocation-associated , neurogenic locus notch homolog protein 1 , translocation-associated notch protein TAN-1 , Motch A , Notch gene homolog 1 , mT14 , major type A protein , p300 , transmembrane receptor Notch1 , Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila) , neurogenic locus notch protein homolog , NOTCH-1

GENE ID SPEZIES
100190917 Oncorhynchus mykiss
100631526 Amphimedon queenslandica
720888 Macaca mulatta
100037842 Xenopus (Silurana) tropicalis
100068764 Equus caballus
100144593 Sus scrofa
100224074 Taeniopygia guttata
4851 Homo sapiens
18128 Mus musculus
25496 Rattus norvegicus
394367 Xenopus laevis
395655 Gallus gallus
464865 Pan troglodytes
480676 Canis lupus familiaris
767866 Bos taurus
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