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in vitro modeling with Hypoplastic left heart syndrome -human induced pluripotent stem cells bearing NOTCH1 mutations facilitated the discovery of a nitric oxide-dependent signaling component essential for cardiovascular cell lineage specification.
Pathogenic mutations in NOTCH1 were identified in 7% of familial left-sided congenital heart disease (LS-CHD (zeige CHDH ELISA Kits)) and in 1% of sporadic LS-CHD (zeige CHDH ELISA Kits). The penetrance is high; a cardiovascular malformation was found in 75% of NOTCH1 mutation carriers
Eogt resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. Combined deficiency of different Notch1 mutant alleles exacerbated the abnormalities in Eogt(-/-) retina, and Notch target gene expression was decreased in Eogt(-/-)endothelial cells.
These data demonstrated fascin (zeige FSCN1 ELISA Kits) as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch self-renewal signaling pathway.
Our overall findings provide preliminary evidence that NOTCH1 may be implicated in the susceptibility to anxiety and depression among sexual abuse victims. The study also underscores the potential importance of animal models for future studies on the health consequences of early-life stress and the mechanisms underlying increased risk for psychiatric disorders.
Results suggest that Notch signalling inhibition may represent a potential therapeutic target not only for lymphoid neoplasms, but also for acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)).
NOTCH1 mutations in CLL are associated with the overexpression of MYC (zeige MYC ELISA Kits) and MYC (zeige MYC ELISA Kits)-related genes involved in protein biosynthesis including NPM1 (zeige NPM1 ELISA Kits), which are allegedly responsible for cell growth and/or proliferation advantages of NOTCH1-mut (zeige MUT ELISA Kits) CLL
Jagged1 (JAG1) thymic medullary niche enriched for dendritic cells (DC)-lineage cells expressing Notch receptors indicate thymus as a DC-poietic organ, which provides selective microenvironments permissive for DC development.
miR (zeige MLXIP ELISA Kits)-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2 (zeige KDM5A ELISA Kits)/NOTCH1/CYCLIN D1 (zeige CCND1 ELISA Kits) coregulatory network.
The Sirt1 (zeige SIRT1 ELISA Kits)-Notch interaction may constitute an important checkpoint that tunes noncanonical Notch1 signaling.
data suggest that Notch signaling is an important regulator of DR and that in steatohepatitis, hepatocytes exposed to Jag1 (zeige JAG1 ELISA Kits)-positive HSC (zeige FUT1 ELISA Kits), contribute to pathologic DR by undergoing Notch-mediated differentiation towards an HPC-like phenotype
Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 (zeige PAX7 ELISA Kits) quiescent satellite cells, leading to severe defects in muscle growth and regeneration, and postnatal lethality. By contrast, myotube-specific Notch1 activation improves the regeneration and exercise performance of aged and dystrophic muscles.
a critical role for PRL2 (zeige PTP4A2 ELISA Kits) phosphatase in mediating Notch and c-Kit (zeige KIT ELISA Kits) signals in early T cell progenitors, is reported.
Protein O-fucosyltransferase1 (Pofut1 (zeige POFUT1 ELISA Kits)), which transfers O-fucose to the EGF (zeige EGF ELISA Kits) domains of the Notch1 receptor, is indispensable for Notch signaling activation
plasticity of Group 3 innate lymphoid cells is regulated by the balance between the opposing effects of Notch and TGF-beta (zeige TGFB1 ELISA Kits) signaling, maintaining homeostasis in the face of continual challenges
the cross-talk between SFRP4 (zeige SFRP4 ELISA Kits), integrin alpha1beta1, and Notch1 suppresses the cardiac differentiation of P19CL6 cells.
we show that Ascl1 (zeige ASCL1 ELISA Kits) induces the transcription factor MyT1 (zeige MYT1 ELISA Kits) while promoting neuronal differentiation...It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting the Notch1 receptor and many of its downstream targets
maternal decidual vascular endothelial cells are able to maintain decidual Regulatory T cells (Treg cell) identity and promote Treg cell differentiation through activation of Notch1 signal pathway.
it is suggested that Notch-1, NF-kappaB (zeige NFKB1 ELISA Kits)/p65 (zeige NFkBP65 ELISA Kits) and GSK-3beta (zeige GSK3b ELISA Kits) operate in synergy to inhibit microglia activation
Epidermal stem cells accelerate diabetic wound healing via the Notch1 signaling pathway; Jag1 (zeige JAG1 ELISA Kits) overexpression improves diabetic wound healing in vivo.
Notch initially destabilises beta-catenin (zeige CTNNB1 ELISA Kits) in a process that does not depend on its phosphorylation by GSK3 (zeige GSK3b ELISA Kits)
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (zeige SHH ELISA Kits) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (zeige MMP11 ELISA Kits) gene or the constitutively active form of Notch (IC).
ZFP423 (zeige 104125 ELISA Kits) coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (zeige HES5 ELISA Kits) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (zeige RBPJ ELISA Kits)) pathway has a significant role in the PGC (zeige PGC ELISA Kits) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (zeige BCL6 ELISA Kits) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (zeige MAML1 ELISA Kits)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin (zeige Actbeta ELISA Kits)-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (zeige SMAD2 ELISA Kits) nuclear localization and the competence of ectodermal cells for activin A (zeige INHBA ELISA Kits) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (zeige NOTCH3 ELISA Kits), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog