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anti-Human Notch1 Antikörper:
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Human Polyclonal Notch1 Primary Antibody für DB, ELISA - ABIN152590
Bertrand, Eckfeldt, Lysholm, LeBien: Notch-1 and Notch-2 exhibit unique patterns of expression in human B-lineage cells. in Leukemia 2001
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Human Monoclonal Notch1 Primary Antibody für ICS, IHC - ABIN967360
Anderson, Robey, Huang: Notch signaling in lymphocyte development. in Current opinion in genetics & development 2001
Show all 8 Pubmed References
Human Polyclonal Notch1 Primary Antibody für IHC - ABIN966679
Ellisen, Bird, West, Soreng, Reynolds, Smith, Sklar: TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. in Cell 1991
Show all 7 Pubmed References
Human Polyclonal Notch1 Primary Antibody für IHC - ABIN966680
Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: Human ligands of the Notch receptor. in The American journal of pathology 1999
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Human Polyclonal Notch1 Primary Antibody für IHC - ABIN966681
Wu, Sun, Kobayashi, Gao, Griffin: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. in Molecular and cellular biology 2002
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Human Monoclonal Notch1 Primary Antibody für FACS, ICC - ABIN807924
Kefas, Comeau, Floyd, Seleverstov, Godlewski, Schmittgen, Jiang, diPierro, Li, Chiocca, Lee, Fine, Abounader, Lawler, Purow: The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
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Human Monoclonal Notch1 Primary Antibody für IHC (f), ICC - ABIN2749161
Tagami, Okochi, Yanagida, Ikuta, Fukumori, Matsumoto, Ishizuka-Katsura, Nakayama, Itoh, Jiang, Nishitomi, Kamino, Morihara, Hashimoto, Tanaka, Kudo, Chiba, Takeda: Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. in Molecular and cellular biology 2007
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Human Monoclonal Notch1 Primary Antibody für CyTOF, FACS - ABIN256488
Ray, Yao, Nowotny, Mumm, Zhang, Wu, Kopan, Goate: Evidence for a physical interaction between presenilin and Notch. in Proceedings of the National Academy of Sciences of the United States of America 1999
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Human Monoclonal Notch1 Primary Antibody für FACS, ICC - ABIN807923
Espinosa, Santos, Inglés-Esteve, Muñoz-Canoves, Bigas: p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR. in Journal of cell science 2002
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Human Monoclonal Notch1 Primary Antibody für ICC, IF - ABIN4340379
Groeneweg, Hall, Zhang, Kim, Byron, Tambouret, Sathayanrayanan, Foster, Rueda, Growdon: Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model. in Gynecologic oncology 2014
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Sirt6 (zeige SIRT6 Antikörper) inhibits Notch1 and Notch4 (zeige NOTCH4 Antikörper) transcription by deacetylating histone H3K9.
increased expression of activated NOTCH1 was found in NOTCH1/FBXW7 (zeige FBXW7 Antikörper) hotspot exon-mutated cases. Study suggests that NOTCH1/FBXW7 (zeige FBXW7 Antikörper) hotspot-mutated T-ALL cases had better response to ALL BFM-95 protocol.
aberrant Notch1 is linked to hepatocellular carcinoma development, tumor recurrence and invasion, which might be mediated, at least in part, through the Notch1-E-Cadherin (zeige CDH1 Antikörper) pathway
Data show that long non-coding RNA HOTAIR was a strong inducer of tumour growth and modulated the expression of epithelial-mesenchymal transition and Notch-Wnt (zeige WNT2 Antikörper) signalling pathway-related genes.
Pim (zeige PIM1 Antikörper) kinases phosphorylate Notch1 on Serine 2152 within the intracellular domain, and thereby enhance the nuclear localization and activity of Notch1. This crosstalk between Pim (zeige PIM1 Antikörper) and Notch proteins enhances tumorigenic growth of breast and prostate cancer cells.
in vitro modeling with Hypoplastic left heart syndrome -human induced pluripotent stem cells bearing NOTCH1 mutations facilitated the discovery of a nitric oxide-dependent signaling component essential for cardiovascular cell lineage specification.
Pathogenic mutations in NOTCH1 were identified in 7% of familial left-sided congenital heart disease (LS-CHD (zeige CHDH Antikörper)) and in 1% of sporadic LS-CHD (zeige CHDH Antikörper). The penetrance is high; a cardiovascular malformation was found in 75% of NOTCH1 mutation carriers
Eogt (zeige C3orf64 Antikörper) resulted in defective retinal angiogenesis, with a mild phenotype similar to that caused by reduced Notch signaling in retina. Combined deficiency of different Notch1 mutant alleles exacerbated the abnormalities in Eogt (zeige C3orf64 Antikörper)(-/-) retina, and Notch target gene expression was decreased in Eogt (zeige C3orf64 Antikörper)(-/-)endothelial cells.
These data demonstrated fascin (zeige FSCN1 Antikörper) as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch self-renewal signaling pathway.
Our overall findings provide preliminary evidence that NOTCH1 may be implicated in the susceptibility to anxiety and depression among sexual abuse victims. The study also underscores the potential importance of animal models for future studies on the health consequences of early-life stress and the mechanisms underlying increased risk for psychiatric disorders.
Notch signaling is required for the formation of all nephron segments and it primes nephron progenitors for differentiation rather than directing their cell fates into a specific nephron segment.
Hypothyroidism induces a significant reduction of proteases Isp1 and Isp2 (zeige PRSS29 Antikörper) gene expressions and Notch signaling.
Results indicate a key role of the Notch1 receptor in myeloid cells for the initiation and progression of experimental autoimmune encephalomyelitis (EAE).
PrP(C (zeige PRNP Antikörper)) controls the expression of the epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)) downstream from Notch.
data suggest that Notch signaling is an important regulator of DR and that in steatohepatitis, hepatocytes exposed to Jag1 (zeige JAG1 Antikörper)-positive HSC (zeige FUT1 Antikörper), contribute to pathologic DR by undergoing Notch-mediated differentiation towards an HPC-like phenotype
Specifically, constitutive Notch1 activation dedifferentiates myocytes into Pax7 (zeige PAX7 Antikörper) quiescent satellite cells, leading to severe defects in muscle growth and regeneration, and postnatal lethality. By contrast, myotube-specific Notch1 activation improves the regeneration and exercise performance of aged and dystrophic muscles.
a critical role for PRL2 (zeige PTP4A2 Antikörper) phosphatase in mediating Notch and c-Kit (zeige KIT Antikörper) signals in early T cell progenitors, is reported.
Protein O-fucosyltransferase1 (Pofut1 (zeige POFUT1 Antikörper)), which transfers O-fucose to the EGF (zeige EGF Antikörper) domains of the Notch1 receptor, is indispensable for Notch signaling activation
plasticity of Group 3 innate lymphoid cells is regulated by the balance between the opposing effects of Notch and TGF-beta (zeige TGFB1 Antikörper) signaling, maintaining homeostasis in the face of continual challenges
Notch initially destabilises beta-catenin (zeige CTNNB1 Antikörper) in a process that does not depend on its phosphorylation by GSK3 (zeige GSK3b Antikörper)
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (zeige SHH Antikörper) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (zeige MMP11 Antikörper) gene or the constitutively active form of Notch (IC).
ZFP423 (zeige 104125 Antikörper) coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (zeige HES5 Antikörper) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (zeige RBPJ Antikörper)) pathway has a significant role in the PGC (zeige PGC Antikörper) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (zeige BCL6 Antikörper) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (zeige MAML1 Antikörper)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin (zeige Actbeta Antikörper)-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (zeige SMAD2 Antikörper) nuclear localization and the competence of ectodermal cells for activin A (zeige INHBA Antikörper) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (zeige NOTCH3 Antikörper), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog