anti-Nicastrin (NCSTN) Antikörper

anti-Nicastrin Antikörper (NCSTN)
Auf finden Sie aktuell 125 Nicastrin (NCSTN) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Nicastrin Proteine (14) und Nicastrin Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 153 Nicastrin Produkte verfügbar.
9430068N19Rik, AA727311, agro, Aph2, CG7012, D1Dau13e, DKFZp469O2418, Dmel\\CG7012, dNct, Kiaa0253, mKIAA0253, NCSTN, Nct, nic, S5A, ST96B

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anti-Human Nicastrin Antikörper:

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Am meisten referenzierte anti-Nicastrin Antikörper

  1. Chicken Monoclonal Nicastrin Primary Antibody für IF, WB - ABIN968805 : Chen, Yu, Arawaka, Nishimura, Kawarai, Yu, Tandon, Supala, Song, Rogaeva, Milman, Sato, Yu, Janus, Lee, Song, Zhang, Fraser, St George-Hyslop: Nicastrin binds to membrane-tethered Notch. in Nature cell biology 2001 (PubMed)
    Zeige alle 2 Referenzen für 968805

Weitere Antikörper gegen Nicastrin Interaktionspartner

Fruit Fly (Drosophila melanogaster) Nicastrin (NCSTN) Interaktionspartner

  1. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (zeige ABCA2 Antikörper)) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

  2. Co-expression of Drosophila Pen-2 (zeige PSENEN Antikörper) with Aph-1 (zeige APH1A Antikörper) and nicastrin increases the formation of Psn fragments as well as gamma-secretase activity

  3. Aph-1 (zeige APH1A Antikörper) and Nct may form a subcomplex that stabilizes the Psn holoprotein at an early step in gamma-secretase assembly.

  4. the proper assembly of the Aph-1 (zeige APH1A Antikörper).nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and Aph-1 (zeige APH1A Antikörper) functions as a stabilizing scaffold in the assembly of this complex

  5. presenilin, nicastrin, APH-1 (zeige APH1A Antikörper), and PEN-2 (zeige PSENEN Antikörper), are present and enriched on phagosome membranes from both murine macrophages and Drosophila S2 phagocytes

  6. Nicastrin is essential to early photoreceptor neuron development

Zebrafish Nicastrin (NCSTN) Interaktionspartner

  1. Zebrafish have an orthologue of human NCSTN, transcripts of the zebrafish ncstn gene are provided maternally, and the gene is then transcribed throughout embryogenesis and in adult zebrafish. Zebrafish ncstn transcripts are present in ventricular cells of the developing brain, Ncstn protein likely plays a role in Notch (zeige NOTCH1 Antikörper) signaling within the proliferative ventricular zone.

Human Nicastrin (NCSTN) Interaktionspartner

  1. The authors identified two nonsynonymous mutations in NCSTN in a white population, one of which had previously been described in African American and Chinese patients with HS. In addition, several intronic polymorphisms within the NCSTN were identified that were present at a significantly higher frequency in the HS population.

  2. The results lead the investigators to speculate that NCSTN may be one of the genes determining the clinical phenotype of follicular HS .

  3. Loss of function of nicastrin impacts on cell proliferation and differentiation-associated signalling pathways in a keratinocyte cell line.

  4. analysis of two novel mutations segregating with familial hidradenitis suppurativa (acne inversa) and acne conglobate in NCSTN

  5. Case Report: large Chinese family harboring novel NCSTN mutation associated with acne inversa.

  6. Nicastrin mutation is associated with schizophrenia.

  7. haploinsufficiency of the NCSTN gene caused by the nonsense mutation c.1258C>T (p.Q420X) contributes to the occurrence of hidradenitis suppurativa in this family.

  8. The "Lid" domain of nicastrin is not essential for regulating gamma-secretase activity.

  9. SNPs in Notch (zeige NOTCH1 Antikörper) pathway genes may be predictors of cutaneous melanoma disease-specific survival.

  10. Tumor necrosis factor-alpha (zeige TNF Antikörper) and interleukin-10 (zeige IL10 Antikörper) levels were elevated in acne inversa patients with nicastrin or presenilin enhancer (zeige PSENEN Antikörper) mutation.

Mouse (Murine) Nicastrin (NCSTN) Interaktionspartner

  1. mice defective of the nicastrin subunit of gamma-secretase in oligodendrocytes have hypomyelination in the central nervous system.

  2. The results of this study showed that elevated p-tau levels in NCT cKO mice and have demonstrated that changes on p-tau were likely caused by enhanced activity of CDK5 (zeige CDK5 Antikörper) but not GSK3beta (zeige GSK3b Antikörper).

  3. PS1 (zeige PSEN1 Antikörper)(exon8) interacts with nicastrin, participating in the gamma-secretase complex formation.

  4. nicastrin plays essential roles in the regulation of short- and long-term synaptic plasticity, highlighting the importance of gamma-secretase in the function of mature synapses

  5. These results reveal a key role for ncstn in modulating amyloid beta production and amyloid plaque formation.

  6. Upregulation of PS1 (zeige PSEN1 Antikörper)/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease.

  7. Pen-2 (zeige PSENEN Antikörper), as well as nicastrin and Aph-1alpha (zeige APH1A Antikörper), is dispensable for presenilin endoproteolysis

  8. SGK1 (zeige SGK1 Antikörper) is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.

  9. We propose a model that identifies critical TMDs of Aph-1 (zeige APH1A Antikörper) for associations with Nct and PS for the stepwise assembly of gamma-secretase components.

  10. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (zeige ABCA2 Antikörper)) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

Nicastrin (NCSTN) Antigen-Profil

Beschreibung des Gens

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease\; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined.

Alternative names and synonyms associated with Nicastrin (NCSTN)

  • nicastrin (NCSTN) Antikörper
  • nicastrin (nct) Antikörper
  • nicastrin (ncstn) Antikörper
  • nicastrin (CpipJ_CPIJ001617) Antikörper
  • nicastrin (Ncstn) Antikörper
  • Protein APH-2 (aph-2) Antikörper
  • 9430068N19Rik Antikörper
  • AA727311 Antikörper
  • agro Antikörper
  • Aph2 Antikörper
  • CG7012 Antikörper
  • D1Dau13e Antikörper
  • DKFZp469O2418 Antikörper
  • Dmel\\CG7012 Antikörper
  • dNct Antikörper
  • Kiaa0253 Antikörper
  • mKIAA0253 Antikörper
  • NCSTN Antikörper
  • Nct Antikörper
  • nic Antikörper
  • S5A Antikörper
  • ST96B Antikörper

Bezeichner auf Proteinebene für anti-Nicastrin (NCSTN) Antikörper

CG7012-PA , CG7012-PC , CG7012-PD , CG7012-PE , agoraphobic , dNicastrin , nct-PA , nct-PC , nct-PD , nct-PE , nicastrin , ATAG1874 , anterior pharynx-defective 2 , membrane protein

100058515 Equus caballus
42964 Drosophila melanogaster
457435 Pan troglodytes
488638 Canis lupus familiaris
494449 Danio rerio
719696 Macaca mulatta
6032584 Culex quinquefasciatus
100170459 Xenopus (Silurana) tropicalis
100172503 Pongo abelii
100549548 Meleagris gallopavo
100596812 Nomascus leucogenys
23385 Homo sapiens
59287 Mus musculus
289231 Rattus norvegicus
426905 Gallus gallus
100156098 Sus scrofa
514929 Bos taurus
172905 Caenorhabditis elegans
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