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anti-Human FURIN Antikörper:
anti-Mouse (Murine) FURIN Antikörper:
anti-Rat (Rattus) FURIN Antikörper:
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Cow (Bovine) Polyclonal FURIN Primary Antibody für IHC (p), ELISA - ABIN2473712
Bray: Notch signalling: a simple pathway becomes complex. in Nature reviews. Molecular cell biology 2006
Human Polyclonal FURIN Primary Antibody für ELISA, WB - ABIN4312814
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
findings uncover a role of ERK1 (zeige MAPK3 Antikörper) in the regulation of furin activity by supporting a self-sustaining loop for high TGF-beta (zeige TGFB1 Antikörper) activity in glioma-initiating cells.
Divers studies have confirmed the expression of furin in a large spectrum of cancers. Functional studies modulating its activity uncovered its importance for the processing of many cancer-related substrates and strongly indicate that high furin activity promotes the malignant phenotype of cancer cells. [review]
Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP (zeige YAP1 Antikörper) pathway and may be a potential target for anti-pancreatic cancer.
Results suggest that (pro)renin receptor (zeige ATP6AP2 Antikörper) (s(P)RR (zeige ATP6AP2 Antikörper)) is generated by sequential processing by site-1 protease (S1P (zeige MBTPS1 Antikörper)) and furin protein.
our study provides evidence that furin activity and epithelial-mesenchymal transition are potential indicators of the aggressive phenotype in recurrent laryngeal cancer after irradiation and that furin is a potentially useful target against laryngeal cancer
Data show that both furin and brain type natriuretic peptide (BNP) were more sensitive than corin (zeige CORIN Antikörper) in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
The authors show that Human papillomavirus type 16 L2 is cleaved during virion morphogenesis in differentiated tissue and that tissue-derived native virus initiates infection independent of cellular furin.
Data suggest that the full Crimean-Congo hemorrhagic fever virus can be reproduced by reverse genetics; in this system, furin cleavage of the nonstructural glycoprotein reveals mature GP38 (zeige PDPN Antikörper).
we could not confirm an effect of the SNP on FURIN expression in vitro and no correlations could be found in vivo with FURIN expression or outcome.
Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.
PC7 (zeige PCSK7 Antikörper) and the related proteases Furin and Pace4 (zeige PCSK6 Antikörper) regulate E-cadherin (zeige CDH1 Antikörper) function during blastocyst formation.
work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation
the role of serpinB8 (zeige SERPINB8 Antikörper)/furin in obesity-associated chronic inflammation
Furin has a role as the primary in vivo convertase of ANGPTL3 (zeige ANGPTL3 Antikörper) and endothelial lipase (zeige LIPG Antikörper) in hepatocytes
overexpression of PCs, furin and PC5 (zeige PCSK5 Antikörper), but not PC7 (zeige PCSK7 Antikörper), which are all expressed in SMC (zeige DYM Antikörper), increase PKGI (zeige PRKG1 Antikörper) cleavage in a dose-dependent manner
we observed an increased susceptibility to UV in single furin transgenic mice that was not substantially enhanced in the double furin/PACE4 (zeige PCSK6 Antikörper) transgenic mice.
These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue.
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9 (zeige PCSK9 Antikörper)) is active and modulates low density lipoprotein receptor (zeige LDLR Antikörper) and serum cholesterol levels.
Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.
furin (paired basic amino acid cleaving enzyme)
, furin A
, furin B
, FES upstream region
, dibasic processing enzyme
, dibasic-processing enzyme
, furin, membrane associated receptor protein
, paired basic amino acid residue-cleaving enzyme
, proprotein convertase subtilisin/kexin type 3
, paired basic amino acid residue cleaving enzyme
, prohormone convertase 3
, subtilisin pro-protein processing enzyme
, paired basic amino acid cleaving enzyme
, trans Golgi network protease furin
, Paired basic amino acid cleaving enzyme (furin)
, Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
, proprotein convertase subtilisin/kexin type3