anti-FBXW7 (FBXW7) Antikörper

Auf www.antikoerper-online.de finden Sie aktuell 138 F-Box and WD Repeat Domain Containing 7 (FBXW7) Antikörper von 19 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FBXW7 Kits (12) und FBXW7 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 161 FBXW7 Produkte verfügbar.
Synonyme:
1110001A17Rik, AGO, Cdc4, FBW6, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, hAgo, hCdc4, SEL-10, SEL10
Alle Antikörper anzeigen Gen GeneID UniProt
FBXW7 100360914  
FBXW7 55294 Q969H0
FBXW7 50754 Q8VBV4

Meistgesuchte Reaktivitäten zu anti-FBXW7 (FBXW7) Antikörper

anti-Rat (Rattus) FBXW7 Antikörper:

anti-Human FBXW7 Antikörper:

anti-Mouse (Murine) FBXW7 Antikörper:

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Weitere Antikörper gegen FBXW7 Interaktionspartner

Human F-Box and WD Repeat Domain Containing 7 (FBXW7) Interaktionspartner

  1. C-MYC (zeige MYC Antikörper) and FBXW7 affect Adult T-cell Leukemia/Lymphoma proliferation and progression, and low FBXW7 may increase C-MYC (zeige MYC Antikörper) expression. C-MYC (zeige MYC Antikörper) was a critical prognostic factor in Adult T-cell Leukemia/Lymphoma patients.

  2. The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  3. Findings demonstrate that Fbw7 targets CDX2 (zeige CDX2 Antikörper) for ubiquitin-mediated proteasome degradation in a GSK3b (zeige GSK3b Antikörper)-dependent manner where GSK3b (zeige GSK3b Antikörper) presumably phosphorylates CDX2 (zeige CDX2 Antikörper) within the two potential phosphodegron motifs.

  4. Plk2 (zeige PLK2 Antikörper) represents an independent prognostic marker and regulates tumor growth and apoptosis by targeting Fbxw7/Cyclin E (zeige CCNE1 Antikörper) pathway in colorectal carcinoma.

  5. Here, we show that the SCFFBW7alpha ubiquitin ligase targets SOX9 (zeige SOX9 Antikörper) for proteasomal degradation and provide experimental evidence of a role for FBW7 in modulating medulloblastoma malignancy and cisplatin resistance by controlling SOX9 (zeige SOX9 Antikörper) proteolysis.

  6. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex.

  7. In colorectal cancers, mutations in the FBXW7 gene were more common in the younger cohort (27.5% vs 9.7%; P = .0022) as were mutations in the proofreading domain of polymerase epsilon catalytic subunit (POLE) (9.8% vs 1%; P = .0048).

  8. Study found that EYA1 (zeige EYA1 Antikörper) affects FBW7-Myc (zeige MYC Antikörper) binding to regulate the FBW7-mediated Myc (zeige MYC Antikörper) degradation machinery.

  9. Our findings reveal a novel regulatory mechanism for SOX9 (zeige SOX9 Antikörper) stability and uncover a unique function of SOX9 (zeige SOX9 Antikörper) in the cellular response to DNA damage. This new mechanism underlying a FBW7-SOX9 (zeige SOX9 Antikörper) axis in cancer could have implications in therapy resistance.

  10. Our results provide a novel mechanistic insight into the activation of Myc (zeige MYC Antikörper) by 27-HC via transcriptional repression of PP2A (zeige PPP2R4 Antikörper), SCP1 (zeige SYCP1 Antikörper) and FBW7 to increase Myc (zeige MYC Antikörper) protein stability in breast cancer cells.

Mouse (Murine) F-Box and WD Repeat Domain Containing 7 (FBXW7) Interaktionspartner

  1. The findings reveal a PLK1 (zeige PLK1 Antikörper)-Fbw7-Myc (zeige MYC Antikörper) signaling circuit that underlies tumorigenesis and validate PLK1 (zeige PLK1 Antikörper) inhibitors, alone or with Bcl2 (zeige BCL2 Antikörper) antagonists, as potential effective therapeutics for MYC (zeige MYC Antikörper)-overexpressing cancers.

  2. Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (zeige YAP1 Antikörper)-dependent mechanism.

  3. Study identifies a REV-ERBalpha (zeige NR1D1 Antikörper) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (zeige CDK1 Antikörper)) phosphorylation of REV-ERBalpha (zeige NR1D1 Antikörper) is recognized by the F-box protein (zeige FBXO30 Antikörper), FBXW7alpha, to direct REV-ERBalpha (zeige NR1D1 Antikörper) degradation via the proteasome. Disruption of this CDK1 (zeige CDK1 Antikörper)-FBXW7-mediated REV-ERBalpha (zeige NR1D1 Antikörper) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  4. Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (zeige FRAP1 Antikörper) pathway in radiation-induced mouse thymic lymphomas.

  5. Prion (zeige PRNP Antikörper) infection induced the expression of FBXW7 in brain.

  6. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (zeige XRCC4 Antikörper) in tumor cells.

  7. data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 (zeige RUNX2 Antikörper) for ubiquitin-mediated degradation in a GSK3beta (zeige GSK3b Antikörper)-dependent manner

  8. In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (zeige USP28 Antikörper), modulate intestinal homeostasis and cancer.

  9. These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.

  10. Dual regulation of Fbw7 activity by Usp28 (zeige USP28 Antikörper) is a safeguard mechanism for maintaining physiological levels of proto-oncogenic Fbw7 substrates, which is equivalently disrupted by loss or overexpression of Usp28 (zeige USP28 Antikörper).

FBXW7 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FBXW7

  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7) Antikörper
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) Antikörper
  • F-box and WD repeat domain containing 7 (FBXW7) Antikörper
  • F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (fbxw7) Antikörper
  • F-box and WD-40 domain protein 7 (Fbxw7) Antikörper
  • 1110001A17Rik Antikörper
  • AGO Antikörper
  • Cdc4 Antikörper
  • FBW6 Antikörper
  • Fbw7 Antikörper
  • Fbwd6 Antikörper
  • Fbx30 Antikörper
  • Fbxo30 Antikörper
  • Fbxw6 Antikörper
  • hAgo Antikörper
  • hCdc4 Antikörper
  • SEL-10 Antikörper
  • SEL10 Antikörper

Bezeichner auf Proteinebene für FBXW7

F-box and WD-40 domain protein 7 , F-box/WD repeat-containing protein 7 , F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) , F-box protein FBW7 , F-box protein FBX30 , F-box protein SEL-10 , archipelago , homolog of C elegans sel-10 , F-box and WD-40 domain protein 7, archipelago homolog , F-box and WD-40 domain-containing protein 7 , F-box protein Fbxw6 , F-box-WD40 repeat protein 6 , f-box only protein 30

GENE ID SPEZIES
100360914 Rattus norvegicus
475465 Canis lupus familiaris
100620112 Sus scrofa
540932 Bos taurus
100145670 Xenopus (Silurana) tropicalis
55294 Homo sapiens
101104688 Ovis aries
50754 Mus musculus
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