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Results show that DLL4 is involved in SYNJ2BP (zeige SYNJ2BP ELISA Kits)-induced hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) development though activating its pathway.
Positive Jagged1 (zeige JAG1 ELISA Kits) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with gallbladder cancers.
We show that GIT1, which also contains an ANK (zeige ANK1 ELISA Kits) domain, inhibits the Notch1 (zeige NOTCH1 ELISA Kits)-Dll4 signaling pathway by competing with Notch1 (zeige NOTCH1 ELISA Kits) ANK (zeige ANK1 ELISA Kits) domain for binding to RBP-J (zeige RBPJ ELISA Kits) in stalk cells
Results provide evidence that DLL4 is associated with gastric cancer stem/progenitor cells (GCSPCs), and its expression impacts CSPC (zeige GZMH ELISA Kits) stemness characteristics associated with the Notch-1 (zeige NOTCH1 ELISA Kits) pathway including self-renewal, differentiation, proliferation, and tumor formation.
The authors present novel structures of human ligands Jagged2 (zeige JAG2 ELISA Kits) and Delta-like4 and human Notch2 (zeige NOTCH2 ELISA Kits), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (zeige NOTCH1 ELISA Kits) binding is likely to be critical in establishing the optimal context for Notch (zeige NOTCH1 ELISA Kits) signalling.
Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (zeige BCL2 ELISA Kits) expression, while decreasing Bax (zeige BAX ELISA Kits) expression, apoptosis rate and DNA damage
In gastric epithelial cells co-cultured with Helicobacter pylori, the expression level of the ligand DLL4 was found to be significantly increased.
Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.
Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (zeige VEGFA ELISA Kits) isoform-dependent manner, and in perivascular cells in a VEGF (zeige VEGFA ELISA Kits)-independent manner. The contribution of VEGF-A (zeige VEGFA ELISA Kits) isoforms to disease progression also indicates that IH may be associated with altered splicing.
Dll4 modulates liver inflammatory response by down-regulating chemokine (zeige CCL1 ELISA Kits) expression
Dll4 seems to promote Apc (zeige APC ELISA Kits) (Min/+) tumorigenesis.
Dll4-Notch1 (zeige NOTCH1 ELISA Kits) signalling couples sprouting angiogenesis and artery formation.
Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.
DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.
The results demonstrate that the Vegf (zeige VEGFA ELISA Kits)-Dll4/Notch (zeige NOTCH1 ELISA Kits) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.
Cyclic AMP Response Element Binding Protein (zeige CREB ELISA Kits) Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (zeige NOTCH1 ELISA Kits) Signaling
miRNA-30e targeted the 3'-UTR (zeige UTS2R ELISA Kits) of Dll4 and downregulated Dll4 expression
Dll4/Notch (zeige NOTCH1 ELISA Kits) signaling and HIF-1alpha (zeige HIF1A ELISA Kits) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (zeige NOTCH1 ELISA Kits) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Tmem230a may have a modulatory role in vessel-network formation and growth, regulating endothelial cell number by Dll4/Notch (zeige NOTCH1 ELISA Kits) pathway.
Thsd7a (zeige THSD7A ELISA Kits) could regulate ISV angiogenesis via Notch (zeige NOTCH1 ELISA Kits)-dll4 signaling. Thus, Thsd7a (zeige THSD7A ELISA Kits) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (zeige NOTCH1 ELISA Kits) signalling via down-regulation of dll4
Microinjection of miR (zeige MYLIP ELISA Kits)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (zeige NOTCH1 ELISA Kits) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (zeige NOTCH1 ELISA Kits) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (zeige NOTCH1 ELISA Kits) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (zeige VEGFC ELISA Kits)/Flt4 (zeige FLT4 ELISA Kits) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2