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Rat (Rattus) ADAM17 Protein expressed in Human Cells - ABIN2009530
Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013
most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (zeige EGFR Proteine)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
In a clinically relevant CADASIL (zeige NOTCH3 Proteine) mouse model, we show that exogenous ADAM17 or HB-EGF (zeige HBEGF Proteine) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (zeige KCNAB2 Proteine) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (zeige TIMP3 Proteine)-induced deficits.
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (zeige IL6 Proteine) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (zeige TNF Proteine)-induced AP-2alpha (zeige TFAP2A Proteine) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (zeige RHBDF2 Proteine) in the regulation of the ADAM17 and EGFR (zeige EGFR Proteine), and ADAM17 and TNFalpha (zeige TNF Proteine) signaling pathways, was examined.
Findings provide evidence that ADAM10 (zeige ADAM10 Proteine), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (zeige NOTCH1 Proteine) signaling.
this study shows that the iRhom2 (zeige RHBDF2 Proteine)/ADAM17 pathway plays an important role in regulating CSF1R (zeige CSF1R Proteine) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (zeige TNF Proteine) and TNFR2 (zeige TNFRSF1B Proteine), thereby preventing overactivation of endogenous TNFR2 (zeige TNFRSF1B Proteine) signaling in cells of the vasculature.
The ADAM17 messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 (zeige ADAM10 Proteine) mRNA and protein levels did not differ significantly between NPs (zeige NPS Proteine) and inferior turbinates (p > 0.05). ADAM10 (zeige ADAM10 Proteine) and ADAM17 were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
The iRhom2 (zeige RHBDF2 Proteine) N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF (zeige TNF Proteine) and EGFR (zeige EGFR Proteine) in inflammatory and innate immune responses. (Review)
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (zeige RPS6KA1 Proteine)-dependent C/EBPbeta (zeige CEBPB Proteine) signaling pathway, which in turn initiates binding of C/EBPbeta (zeige CEBPB Proteine) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (zeige TNFSF11 Proteine) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Proteine) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Proteine) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
Our data demonstrated that elevated serum Semaphorin5A (Sema5A (zeige SEMA5A Proteine)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (zeige SEMA5A Proteine).
ADAM17 and ADAM10 (zeige ADAM10 Proteine) cleave Nectin-4 (zeige PVRL4 Proteine) and release soluble Nectin-4 (zeige PVRL4 Proteine) (sN4).
ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.
ADAM17 was involved in porcine CD16 (zeige CD16 Proteine) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (zeige CD163 Proteine) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (zeige FYN Proteine)-induced c-Src (zeige SRC Proteine)-dependent manner mediates proteolytic activation of the EGF (zeige EGF Proteine)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (zeige TNF Proteine) stimulates Rac (zeige AKT1 Proteine), ADAM17/TACE, and RhoA (zeige RHOA Proteine) through the guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) (GEF)-H1 (zeige ARHGEF2 Proteine).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (zeige EGF Proteine) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme