ADAM17 Proteine (ADAM17)

Bezeichnung:
ADAM Metallopeptidase Domain 17 Proteine (ADAM17)
Auf www.antikoerper-online.de finden Sie aktuell 17 ADAM Metallopeptidase Domain 17 (ADAM17) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ADAM17 Antikörper (272) und ADAM17 Kits (34) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 332 ADAM17 Produkte verfügbar.
Synonyme:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace
alle Proteine anzeigen Gen GeneID UniProt
ADAM17 11491 Q9Z0F8
ADAM17 6868 P78536
ADAM17 57027 Q9Z1K9

Weitere Synonyme anzeigen

ADAM17 Proteine (ADAM17) nach Spezies

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Am meisten referenzierte ADAM17 Proteine

  1. Rat (Rattus) ADAM17 Protein expressed in Human Cells - ABIN2009530 : Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway. in The Journal of biological chemistry 2013 (PubMed)

Weitere Proteine zu ADAM17 Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.

  2. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (zeige IL6 Proteine) signals during inflammatory processes.

  3. These results show that TACE is a target of, and is downregulated by, soluble TNF (zeige TNF Proteine)-induced AP-2alpha (zeige TFAP2A Proteine) transcription factor in dendritic cells

  4. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (zeige RHBDF2 Proteine) in the regulation of the ADAM17 and EGFR (zeige EGFR Proteine), and ADAM17 and TNFalpha (zeige TNF Proteine) signaling pathways, was examined.

  5. Findings provide evidence that ADAM10 (zeige ADAM10 Proteine), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (zeige NOTCH1 Proteine) signaling.

  6. this study shows that the iRhom2 (zeige RHBDF2 Proteine)/ADAM17 pathway plays an important role in regulating CSF1R (zeige CSF1R Proteine) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation

  7. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (zeige TNF Proteine) and TNFR2 (zeige TNFRSF1B Proteine), thereby preventing overactivation of endogenous TNFR2 (zeige TNFRSF1B Proteine) signaling in cells of the vasculature.

  8. Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Proteine) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Proteine) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  9. Thus, Leda-1/Pianp (zeige C12orf53 Proteine) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (zeige ADAM10 Proteine)/17 and intramembrane protease gamma-secretase.

  10. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (zeige AXL Proteine)kinase (Axl) in lupus-prone leukocytes.

Human ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (zeige TNFSF11 Proteine) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  2. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  3. Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Proteine) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Proteine) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  4. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (zeige SEMA5A Proteine)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (zeige SEMA5A Proteine).

  5. ADAM17 and ADAM10 (zeige ADAM10 Proteine) cleave Nectin-4 (zeige PVRL4 Proteine) and release soluble Nectin-4 (zeige PVRL4 Proteine) (sN4).

  6. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  7. FHL2 (zeige FHL2 Proteine) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (zeige FHL2 Proteine) complex in the development of colorectal cancer.

  8. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (zeige EGFR Proteine)-PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine) signaling pathway

  9. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (zeige AXL Proteine)) is rescued by combined matrix metalloproteases ADAM10 (zeige ADAM10 Proteine) and TACE (ADAM17) inhibition.

  10. the TLR4 (zeige TLR4 Proteine)/Gal-1 (zeige LGALS1 Proteine) signaling pathway regulates lactate-mediated EMT (zeige ITK Proteine) processes through the activation of ADAM10 (zeige ADAM10 Proteine) and ADAM17 in colon cancer cells.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. ADAM17 was involved in porcine CD16 (zeige CD16 Proteine) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (zeige CD163 Proteine) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (zeige FYN Proteine)-induced c-Src (zeige SRC Proteine)-dependent manner mediates proteolytic activation of the EGF (zeige EGF Proteine)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (zeige TNF Proteine) stimulates Rac (zeige AKT1 Proteine), ADAM17/TACE, and RhoA (zeige RHOA Proteine) through the guanine nucleotide exchange factor (zeige ARHGEF12 Proteine) (GEF)-H1 (zeige ARHGEF2 Proteine).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (zeige EGF Proteine) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Protein Überblick

Protein Überblick

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17)
  • a disintegrin and metallopeptidase domain 17b (adam17b)
  • ADAM metallopeptidase domain 17 (adam17)
  • a disintegrin and metallopeptidase domain 17 (Adam17)
  • ADAM metallopeptidase domain 17 (Adam17)
  • adam17 Protein
  • ADAM18 Protein
  • CD156B Protein
  • CSVP Protein
  • NISBD Protein
  • si:dkey-81b15.2 Protein
  • Tace Protein

Bezeichner auf Proteinebene für ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPEZIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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