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anti-Mouse (Murine) ADAM17 Antikörper:
anti-Human ADAM17 Antikörper:
anti-Rat (Rattus) ADAM17 Antikörper:
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Human Monoclonal ADAM17 Primary Antibody für CyTOF, FACS - ABIN4900517
Zingoni, Cecere, Vulpis, Fionda, Molfetta, Soriani, Petrucci, Ricciardi, Fuerst, Amendola, Mytilineos, Cerboni, Paolini, Cippitelli, Santoni: Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. in Journal of immunology (Baltimore, Md. : 1950) 2015
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Human Monoclonal ADAM17 Primary Antibody für CyTOF, FACS - ABIN4900516
Breshears, Schlievert, Peterson: A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1). in The Journal of biological chemistry 2012
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Human Monoclonal ADAM17 Primary Antibody für FACS - ABIN4897862
Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005
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Human Polyclonal ADAM17 Primary Antibody für IHC - ABIN965510
Rabie, Strehl, Ludwig, Nieswandt: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. in The Journal of biological chemistry 2005
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Human Monoclonal ADAM17 Primary Antibody für FACS - ABIN4897863
Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012
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Human Polyclonal ADAM17 Primary Antibody für ICC, ELISA - ABIN1003300
Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997
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Human Monoclonal ADAM17 Primary Antibody für IHC (p), PLA - ABIN563080
Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. in British journal of cancer 2009
Human Polyclonal ADAM17 Primary Antibody für ICC, ELISA - ABIN1003301
Rosendahl, Ko, Long, Brewer, Rosenzweig, Hedl, Anderson, Pyle, Moreland, Meyers, Kohno, Lyons, Lichenstein: Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases. in The Journal of biological chemistry 1997
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Human Polyclonal ADAM17 Primary Antibody für ICC, FACS - ABIN1030720
McGowan, Mullooly, Caiazza, Sukor, Madden, Maguire, Pierce, McDermott, Crown, ODonovan, Duffy: ADAM-17: a novel therapeutic target for triple negative breast cancer. in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013
Chicken Polyclonal ADAM17 Primary Antibody für ELISA, WB - ABIN2478641
Umetsu, Yamashita, Suzuki: Purification and carbohydrate-binding specificities of a blood type B binding lectin from hemolymph of a crab (Charybdis japonica). in Journal of biochemistry 1991
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most defects in formation of the postnatal epidermal barrier upon keratinocyte-specific ADAM17 deletion are mediated via EGFR (zeige EGFR Antikörper)
ADAM17 is either not required in T cells under homoeostatic conditions and for control of listeria infection or can be effectively compensated by other mechanisms
In a clinically relevant CADASIL (zeige NOTCH3 Antikörper) mouse model, we show that exogenous ADAM17 or HB-EGF (zeige HBEGF Antikörper) restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (zeige KCNAB2 Antikörper) (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3 (zeige TIMP3 Antikörper)-induced deficits.
Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.
These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (zeige IL6 Antikörper) signals during inflammatory processes.
These results show that TACE is a target of, and is downregulated by, soluble TNF (zeige TNF Antikörper)-induced AP-2alpha (zeige TFAP2A Antikörper) transcription factor in dendritic cells
the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (zeige RHBDF2 Antikörper) in the regulation of the ADAM17 and EGFR (zeige EGFR Antikörper), and ADAM17 and TNFalpha (zeige TNF Antikörper) signaling pathways, was examined.
Findings provide evidence that ADAM10 (zeige ADAM10 Antikörper), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (zeige NOTCH1 Antikörper) signaling.
this study shows that the iRhom2 (zeige RHBDF2 Antikörper)/ADAM17 pathway plays an important role in regulating CSF1R (zeige CSF1R Antikörper) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation
Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (zeige TNF Antikörper) and TNFR2 (zeige TNFRSF1B Antikörper), thereby preventing overactivation of endogenous TNFR2 (zeige TNFRSF1B Antikörper) signaling in cells of the vasculature.
the chaperone 78-kDa glucose-regulated protein (GRP78 (zeige HSPA5 Antikörper)) protects the MPD (zeige MVD Antikörper) against PDI (zeige PADI1 Antikörper)-dependent disulfide-bond isomerization by binding to this domain and, thereby, preventing ADAM17 inhibition.
The ADAM17 messenger RNA (mRNA) and protein levels were significantly higher in the inferior turbinate than in nasal polyps (p < 0.05). The ADAM10 (zeige ADAM10 Antikörper) mRNA and protein levels did not differ significantly between NPs (zeige NPS Antikörper) and inferior turbinates (p > 0.05). ADAM10 (zeige ADAM10 Antikörper) and ADAM17 were expressed primarily in inflammatory cells, submucosal glandular cells, and lining epithelial cells.
The iRhom2 (zeige RHBDF2 Antikörper) N-terminus stabilizes mature ADAM17 at the cell surface where it cleaves TNF (zeige TNF Antikörper) and EGFR (zeige EGFR Antikörper) in inflammatory and innate immune responses. (Review)
inhibition of ADAM17 enhanced the purity of expanded NK cells and the antibody-dependent cellular cytotoxicity activity of these cells against trastuzumab treated breast cancer cell lines.
hypoxia instigates the RSK1 (zeige RPS6KA1 Antikörper)-dependent C/EBPbeta (zeige CEBPB Antikörper) signaling pathway, which in turn initiates binding of C/EBPbeta (zeige CEBPB Antikörper) to the ADAM 17 promoter and ultimately induces ADAM 17 expression in human lung fibroblasts.
TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (zeige TNFSF11 Antikörper) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.
Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.
Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Antikörper) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Antikörper) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.
Our data demonstrated that elevated serum Semaphorin5A (Sema5A (zeige SEMA5A Antikörper)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (zeige SEMA5A Antikörper).
ADAM17 and ADAM10 (zeige ADAM10 Antikörper) cleave Nectin-4 (zeige PVRL4 Antikörper) and release soluble Nectin-4 (zeige PVRL4 Antikörper) (sN4).
ADAM17 was involved in porcine CD16 (zeige CD16 Antikörper) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.
Overexpression of ADAM17 induced downregulation of CD163 (zeige CD163 Antikörper) expression and a reduction in reproductive and respiratory syndrome virus infection.
activation of TACE/ADAM17 via a PKC (zeige FYN Antikörper)-induced c-Src (zeige SRC Antikörper)-dependent manner mediates proteolytic activation of the EGF (zeige EGF Antikörper)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes
Data indicate that TNF-alpha (zeige TNF Antikörper) stimulates Rac (zeige AKT1 Antikörper), ADAM17/TACE, and RhoA (zeige RHOA Antikörper) through the guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) (GEF)-H1 (zeige ARHGEF2 Antikörper).
progesterone-induced TACE/ADAM17 leads to production of soluble EGF (zeige EGF Antikörper) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme)
, disintegrin and metalloproteinase domain-containing protein 17
, tumor necrosis factor alpha converting enzyme
, a disintegrin and metallopeptidase domain 17
, ADAM metallopeptidase domain 17
, a disintegrin and metalloprotease domain 17
, disintegrin metalloproteinase
, disintegrin and metalloproteinase domain-containing protein 17-like
, ADAM 17
, TNF-alpha convertase
, TNF-alpha converting enzyme
, TNF-alpha-converting enzyme
, a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme
, a disintegrin and metalloproteinase domain 17
, ADAM metallopeptidase domain 18
, snake venom-like protease
, tumor necrosis factor, alpha, converting enzyme