anti-ADAM17 (ADAM17) Antikörper

Bezeichnung:
anti-ADAM Metallopeptidase Domain 17 Antikörper (ADAM17)
Auf www.antikoerper-online.de finden Sie aktuell 272 ADAM Metallopeptidase Domain 17 (ADAM17) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ADAM17 Kits (34) und ADAM17 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 332 ADAM17 Produkte verfügbar.
Synonyme:
adam17, ADAM18, CD156B, CSVP, NISBD, si:dkey-81b15.2, Tace

Meistgesuchte Reaktivitäten zu anti-ADAM17 (ADAM17) Antikörper

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anti-Mouse (Murine) ADAM17 Antikörper:

anti-Human ADAM17 Antikörper:

anti-Rat (Rattus) ADAM17 Antikörper:

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Am meisten referenzierte anti-ADAM17 Antikörper

  1. Human Monoclonal ADAM17 Primary Antibody für FACS - ABIN4897862 : Kermarrec, Selloum, Plantefeve, Chosidow, Paoletti, Lopez, Mantz, Desmonts, Gougerot-Pocidalo, Chollet-Martin: Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. in Critical care medicine 2005 (PubMed)
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  2. Human Monoclonal ADAM17 Primary Antibody für FACS - ABIN4897863 : Moreira-Tabaka, Peluso, Vonesch, Hentsch, Kessler, Reimund, Dumont, Muller: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. in PLoS ONE 2012 (PubMed)
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  3. Human Polyclonal ADAM17 Primary Antibody für ELISA, WB - ABIN1531481 : Bilousova, Taylor, Emirzian, Gylys, Frautschy, Cole, Teng: Parallel age-associated changes in brain and plasma neuronal pentraxin receptor levels in a transgenic APP/PS1 rat model of Alzheimer's disease. in Neurobiology of disease 2015 (PubMed)
    Zeige alle 3 Referenzen für 1531481

  4. Human Polyclonal ADAM17 Primary Antibody für ELISA, WB - ABIN1536098 : Moss, Jin, Milla, Bickett, Burkhart, Carter, Chen, Clay, Didsbury, Hassler, Hoffman, Kost, Lambert, Leesnitzer, McCauley, McGeehan, Mitchell, Moyer, Pahel, Rocque, Overton, Schoenen, Seaton, Su et al.: Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha. ... in Nature 1997 (PubMed)
    Zeige alle 2 Referenzen für 1536098

  5. Human Polyclonal ADAM17 Primary Antibody für FACS, WB - ABIN388309 : Tellier, Canault, Poggi, Bonardo, Nicolay, Alessi, Nalbone, Peiretti: HDLs activate ADAM17-dependent shedding. in Journal of cellular physiology 2007 (PubMed)
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  6. Human Polyclonal ADAM17 Primary Antibody für EIA, WB - ABIN357025 : Takamune, Ikebe, Nagano, Shinohara: Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma. in Biochemical and biophysical research communications 2007 (PubMed)
    Zeige alle 2 Referenzen für 357025

  7. Human Polyclonal ADAM17 Primary Antibody für ELISA, WB - ABIN184721 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)

  8. Human Polyclonal ADAM17 Primary Antibody für FACS, IF (p) - ABIN705671 : Li, Xie, He, Wang, Duan, Yang, Wang: Identification of ADAM10 and ADAM17 with potential roles in the spermatogenesis of the Chinese mitten crab, Eriocheir sinensis. in Gene 2015 (PubMed)

Weitere Antikörper gegen ADAM17 Interaktionspartner

Mouse (Murine) ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. Conditional ADAM17 knockout mice lacking ADAM17 in all leukocytes had a significant survival advantage during severe polymicrobial sepsis induced by CLP, associated with enhanced neutrophil recruitment at the infectious locus along with decreased bacterial spread and circulating levels of proinflammatory factors. Its induction during sepsis may tip the balance between efficient and impaired neutrophil recruitment.

  2. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 (zeige IL6 Antikörper) signals during inflammatory processes.

  3. These results show that TACE is a target of, and is downregulated by, soluble TNF (zeige TNF Antikörper)-induced AP-2alpha (zeige TFAP2A Antikörper) transcription factor in dendritic cells

  4. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 (zeige RHBDF2 Antikörper) in the regulation of the ADAM17 and EGFR (zeige EGFR Antikörper), and ADAM17 and TNFalpha (zeige TNF Antikörper) signaling pathways, was examined.

  5. Findings provide evidence that ADAM10 (zeige ADAM10 Antikörper), and not ADAM17, is indispensable for proper retinal development as a regulator of NOTCH (zeige NOTCH1 Antikörper) signaling.

  6. this study shows that the iRhom2 (zeige RHBDF2 Antikörper)/ADAM17 pathway plays an important role in regulating CSF1R (zeige CSF1R Antikörper) expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation

  7. Suggest an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFalpha (zeige TNF Antikörper) and TNFR2 (zeige TNFRSF1B Antikörper), thereby preventing overactivation of endogenous TNFR2 (zeige TNFRSF1B Antikörper) signaling in cells of the vasculature.

  8. Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Antikörper) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Antikörper) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  9. Thus, Leda-1/Pianp (zeige C12orf53 Antikörper) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10 (zeige ADAM10 Antikörper)/17 and intramembrane protease gamma-secretase.

  10. Matrix metalloproteases ADAM10 and TACE (ADAM17) cleave AXL receptor tyrosine (zeige AXL Antikörper)kinase (Axl) in lupus-prone leukocytes.

Human ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. TNF-alpha-converting enzyme -mediated cleavage of soluble RANKL (zeige TNFSF11 Antikörper) from activated lymphocytes, especially B cells, can promote osteoclastogenesis in periodontitis.

  2. Cell stimulation can downregulate expression of mature ADAM17 from the cell surface and induce release of exosomal ADAM17, which can then distribute and contribute to substrate shedding on more distant cells.

  3. Aging and obesity cooperatively reduce caveolin-1 (zeige CAV1 Antikörper) expression and increase vascular endothelial ADAM17 activity and soluble TNF (zeige TNF Antikörper) release in adipose tissue, which may contribute to the development of remote coronary microvascular dysfunction in older obese patients.

  4. Our data demonstrated that elevated serum Semaphorin5A (Sema5A (zeige SEMA5A Antikörper)) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A (zeige SEMA5A Antikörper).

  5. ADAM17 and ADAM10 (zeige ADAM10 Antikörper) cleave Nectin-4 (zeige PVRL4 Antikörper) and release soluble Nectin-4 (zeige PVRL4 Antikörper) (sN4).

  6. ADAM17 promotes epithelial-mesenchymal transition via the TGF-beta (zeige TGFB1 Antikörper)/Smad (zeige SMAD1 Antikörper) pathway. the present study demonstrates that ADAM17 plays a critical role in the development of gastric cancer and provides a potential therapeutic target for gastric cancer.

  7. FHL2 (zeige FHL2 Antikörper) interacts with ADAM-17 in normal, dysplastic and malignant colon epithelial cells. Colocalisation of these proteins is more frequent in malignant than in normal and dysplastic cells, suggesting a role for ADAM-17/FHL2 (zeige FHL2 Antikörper) complex in the development of colorectal cancer.

  8. The present study suggests that ADAM17-siRNA inhibits MCF-7 breast cancer and is activated through the EGFR (zeige EGFR Antikörper)-PI3K (zeige PIK3CA Antikörper)-AKT (zeige AKT1 Antikörper) signaling pathway

  9. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (zeige AXL Antikörper)) is rescued by combined matrix metalloproteases ADAM10 (zeige ADAM10 Antikörper) and TACE (ADAM17) inhibition.

  10. the TLR4 (zeige TLR4 Antikörper)/Gal-1 (zeige LGALS1 Antikörper) signaling pathway regulates lactate-mediated EMT (zeige ITK Antikörper) processes through the activation of ADAM10 (zeige ADAM10 Antikörper) and ADAM17 in colon cancer cells.

Pig (Porcine) ADAM Metallopeptidase Domain 17 (ADAM17) Interaktionspartner

  1. ADAM17 was involved in porcine CD16 (zeige CD16 Antikörper) shedding in porcine reproductive and respiratory syndrome virus-infected pigs.

  2. Overexpression of ADAM17 induced downregulation of CD163 (zeige CD163 Antikörper) expression and a reduction in reproductive and respiratory syndrome virus infection.

  3. activation of TACE/ADAM17 via a PKC (zeige FYN Antikörper)-induced c-Src (zeige SRC Antikörper)-dependent manner mediates proteolytic activation of the EGF (zeige EGF Antikörper)-like factors that are involved in the induction of granulosa cell differentiation, cumulus expansion, and meiotic maturation of porcine oocytes

  4. Data indicate that TNF-alpha (zeige TNF Antikörper) stimulates Rac (zeige AKT1 Antikörper), ADAM17/TACE, and RhoA (zeige RHOA Antikörper) through the guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) (GEF)-H1 (zeige ARHGEF2 Antikörper).

  5. progesterone-induced TACE/ADAM17 leads to production of soluble EGF (zeige EGF Antikörper) domain from cumulus cells, which enhances functional changes of cumulus cells and progresses meiotic maturation of oocytes

ADAM17 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway.

Alternative names and synonyms associated with ADAM17

  • ADAM metallopeptidase domain 17 (ADAM17) Antikörper
  • a disintegrin and metallopeptidase domain 17b (adam17b) Antikörper
  • ADAM metallopeptidase domain 17 (adam17) Antikörper
  • a disintegrin and metallopeptidase domain 17 (Adam17) Antikörper
  • ADAM metallopeptidase domain 17 (Adam17) Antikörper
  • adam17 Antikörper
  • ADAM18 Antikörper
  • CD156B Antikörper
  • CSVP Antikörper
  • NISBD Antikörper
  • si:dkey-81b15.2 Antikörper
  • Tace Antikörper

Bezeichner auf Proteinebene für ADAM17

ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) , a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) , disintegrin and metalloproteinase domain-containing protein 17 , tumor necrosis factor alpha converting enzyme , a disintegrin and metallopeptidase domain 17 , ADAM metallopeptidase domain 17 , a disintegrin and metalloprotease domain 17 , disintegrin metalloproteinase , disintegrin and metalloproteinase domain-containing protein 17-like , ADAM 17 , TNF-alpha convertase , TNF-alpha converting enzyme , TNF-alpha-converting enzyme , a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme , a disintegrin and metalloproteinase domain 17 , ADAM metallopeptidase domain 18 , snake venom-like protease , tumor necrosis factor, alpha, converting enzyme

GENE ID SPEZIES
421931 Gallus gallus
459018 Pan troglodytes
560657 Danio rerio
694429 Macaca mulatta
733430 Xenopus laevis
100072496 Equus caballus
100406520 Callithrix jacchus
100482770 Ailuropoda melanoleuca
11491 Mus musculus
6868 Homo sapiens
57027 Rattus norvegicus
475662 Canis lupus familiaris
397343 Sus scrofa
517541 Bos taurus
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