ADAM10 Proteine (ADAM10)

Bezeichnung:
ADAM Metallopeptidase Domain 10 Proteine (ADAM10)
Auf www.antikoerper-online.de finden Sie aktuell 21 ADAM Metallopeptidase Domain 10 (ADAM10) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ADAM10 Antikörper (168) und ADAM10 Kits (44) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 237 ADAM10 Produkte verfügbar.
Synonyme:
1700031C13Rik, ad10, ADAM-10, ADAM 10, Adam10, cd156c, HsT18717, kuz, kuzbanian, LOC100219653, madm, wu:fc03d12, xadam10
alle Proteine anzeigen Gen GeneID UniProt
ADAM10 11487 O35598
ADAM10 102 O14672
ADAM10 29650  

Weitere Synonyme anzeigen

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Weitere Proteine zu ADAM10 Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase Domain 10 (ADAM10) Interaktionspartner

  1. these results show that ADAM10-Notch (zeige NOTCH1 Proteine) signaling in ovarian somatic cells governs the primordial follicle formation by controlling the development of ovarian pregranulosa cells.

  2. Findings provide evidence that ADAM10, and not ADAM17 (zeige ADAM17 Proteine), is indispensable for proper retinal development as a regulator of NOTCH (zeige NOTCH1 Proteine) signaling.

  3. this study shows that during positive selection in the spleen, B-cell receptor signaling causes immature type 1 transitional B cells to become receptive to Notch (zeige NOTCH1 Proteine) ligands via Taok3 (zeige TAOK3 Proteine)-mediated surface expression of ADAM10

  4. Thus, Leda-1/Pianp (zeige C12orf53 Proteine) is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.

  5. ADAM10 was dispensable for alpha-toxin (zeige PLC Proteine)-dependent xenophagic targeting of S. aureus, whereas a role for alpha-toxin (zeige PLC Proteine) attack on the plasma membrane was confirmed.

  6. ADAM10 was essentially involved in maxillofacial bone development. ADAM10 conditional knock-out KO mice present craniofacial dysmorphia and bone defects. Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

  7. Newborn mice deficient in ADAM10 exhibited organ-specific vascular defects.

  8. Findings demonstrate the direct requirement of ADAM10 in cortical radial migration and reveal the underlying mechanism by linking ADAM10-initiated regulated intramembrane proteolysis of Notch (zeige NOTCH1 Proteine) to the regulation of microtubule cytoskeleton through transcriptional control of Dcx (zeige DCX Proteine) expression

  9. our data afford the new insight that miR (zeige MLXIP Proteine)-103a inhibited abdominal aortic aneurysm (AAA (zeige AAAS Proteine)) growth via targeting ADAM10, which might be a promising therapeutic strategy to alleviate AAA (zeige AAAS Proteine).

  10. ADAM10 gene was predominantly expressed in the neurons of the cerebral cortex, hippocampus, thalamus and cerebellar granular cells in adult mouse CNS.

Human ADAM Metallopeptidase Domain 10 (ADAM10) Interaktionspartner

  1. Regulation of ADAM10 by the TspanC8 subgroup of tetraspanins, namely Tspan5 (zeige TSPAN5 Proteine), 10, 14, 15, 17 and 33 is reviewed.

  2. active ADAM10 form marks cancer stem-like cells with active Notch (zeige NOTCH1 Proteine) signaling, known to mediate chemoresistance.

  3. Data show that tetraspanin 33 (tspan33 (zeige TSPAN33 Proteine)) is an early activation marker, and that disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) protein expression does not correlate with Tspan33 (zeige TSPAN33 Proteine) expression in B cells.

  4. High ADAM10 expression is associated with metastasis of hepatocellular carcinoma.

  5. The dysregulation of ADAM10, Fas (zeige FAS Proteine) and FasL (zeige FASL Proteine) could be useful indicators of the progression and severity of OSCC.

  6. 1,25D3 causes ectodomain shedding of TLR4 (zeige TLR4 Proteine) and thereby decreases the responsiveness of cells to LPS (zeige IRF6 Proteine). ADAM10, activated by extracellular Ca2 (zeige CA2 Proteine)+ influx, was implicated in the ectodomain cleavage of TLR4 (zeige TLR4 Proteine).

  7. The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease.

  8. Pre-incubation with simvastatin prior to treatment with IL-1beta (zeige IL1B Proteine) + Oncostatin M (zeige OSM Proteine) decreased the level of CD44 (zeige CD44 Proteine) fragmentation, decreased the proportion of CD44 (zeige CD44 Proteine) that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 (zeige CD44 Proteine) and ADAM10.

  9. ADAM17 (zeige ADAM17 Proteine) and ADAM10 cleave Nectin-4 (zeige PVRL4 Proteine) and release soluble Nectin-4 (zeige PVRL4 Proteine) (sN4).

  10. Data show that mononuclear leukocytes (PBMC) AXL receptor tyrosine kinase (Axl (zeige AXL Proteine)) is rescued by combined matrix metalloproteases ADAM10 and TACE (ADAM17 (zeige ADAM17 Proteine)) inhibition.

Xenopus laevis ADAM Metallopeptidase Domain 10 (ADAM10) Interaktionspartner

  1. A dramatic decline in ephrinB2 (zeige EFNB2 PLURAL_@34830@) protein levels on the absence of flotillin-1 (zeige FLOT1 PLURAL_@34830@) expression is specific, and is partly the result of an increased susceptibility to cleavage by the metalloprotease (zeige ADAM8 PLURAL_@34830@) ADAM10.

Pig (Porcine) ADAM Metallopeptidase Domain 10 (ADAM10) Interaktionspartner

  1. significantly increased expression of ADAM10 in the ISR versus non-ISR segment in diabetic minipigs

Cow (Bovine) ADAM Metallopeptidase Domain 10 (ADAM10) Interaktionspartner

  1. Data show that ADAM10 and APLP2 (zeige APLP2 Proteine) are expressed in proximal tubule cells, and that ADAM10 activity has a pronounced effect on expression of specific brush-border proteins.

  2. Intracellular trafficking of ADAM10 critically requires a novel sorting signal within its cytoplasmic domain.

  3. N-glycosylation is crucial for ADAM10 processing and resistance to proteolysis, and results suggest that it is required for full-enzyme activity.

ADAM10 Protein Überblick

Protein Überblick

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin.

Alternative names and synonyms associated with ADAM10

  • a disintegrin and metalloprotease domain 10a (adam10a)
  • ADAM metallopeptidase domain 10 (ADAM10)
  • ADAM metallopeptidase domain 10 (LOC100219653)
  • ADAM metallopeptidase domain 10 (Adam10)
  • a disintegrin and metallopeptidase domain 10 (Adam10)
  • ADAM metallopeptidase domain 10 (adam10)
  • ADAM10 (LOC100101614)
  • 1700031C13Rik Protein
  • ad10 Protein
  • ADAM-10 Protein
  • ADAM 10 Protein
  • Adam10 Protein
  • cd156c Protein
  • HsT18717 Protein
  • kuz Protein
  • kuzbanian Protein
  • LOC100219653 Protein
  • madm Protein
  • wu:fc03d12 Protein
  • xadam10 Protein

Bezeichner auf Proteinebene für ADAM10

a disintegrin and metalloprotease domain 10a , ADAM metallopeptidase domain 10 , disintegrin and metalloproteinase domain-containing protein 10 , ADAM10 metallopeptidase , disintegrin and metalloproteinase domain-containing protein 10-like , ADAM 10 , a disintegrin and metalloprotease domain (ADAM) 10 , a disintegrin and metalloprotease domain 10 , kuzbanian protein homolog , mammalian disintegrin-metalloprotease , CDw156 , a disintegrin and metalloproteinase domain 10 , metalloprotease/disintegrin , xKuz , a disintegrin and metallopeptidase domain 10 , disintegrin-metalloproteinase , myelin-associated metalloproteinase

GENE ID SPEZIES
566044 Danio rerio
701355 Macaca mulatta
746942 Pan troglodytes
100068314 Equus caballus
100169741 Pongo abelii
100219653 Taeniopygia guttata
100313545 Saccoglossus kowalevskii
100476350 Ailuropoda melanoleuca
100606667 Nomascus leucogenys
11487 Mus musculus
102 Homo sapiens
399187 Xenopus laevis
29650 Rattus norvegicus
374113 Gallus gallus
478321 Canis lupus familiaris
397345 Sus scrofa
282132 Bos taurus
100718999 Cavia porcellus
100101614 Oryctolagus cuniculus
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