anti-Maus Tumor Necrosis Factor Antikörper für Biochemical Assay

Recommended Tumor Necrosis Factor Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Tumor Necrosis Factor (TNF) Antikörper
  • TNF
  • tnf
  • dif
  • tnfa
  • xtnf
  • TNF-a
  • tnfsf2
  • tnf-alpha
  • TNF-alpha
  • DIF
  • TNFA
  • TNFSF2
  • TNFalpha
  • Tnfa
  • Tnfsf1a
  • RATTNF
  • TNFa
  • cTNF
  • TNF-ALPHA
  • Cachectin
  • Tnf-alpha
  • tnfa-like
  • tumor necrosis factor (TNF superfamily, member 2)
  • tumor necrosis factor
  • tumour necrosis factor alpha-like
  • tumor necrosis factor alpha
  • lipopolysaccharide-induced TNF factor
  • tumor necrosis factor b (TNF superfamily, member 2)
  • TNF
  • tnf
  • tnf-alpha
  • LITAF
  • Tnf
  • tnfb
Reaktivität
Maus
1259
464
359
145
136
119
119
63
55
41
29
18
14
12
9
7
6
4
4
4
4
2
1
1
1
1
Wirt
Ratte
942
521
185
49
10
9
7
6
4
3
2
Klonalität
Monoklonal
Konjugat
Dieser Tumor Necrosis Factor Antikörper ist konjugiert mit PerCP-Cy5.5
169
100
78
50
32
30
28
27
26
25
25
25
25
25
24
24
24
23
13
9
8
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Biochemical Assay (BCA)
888
860
633
323
287
230
221
191
139
118
97
69
30
29
26
22
20
18
14
9
8
7
6
6
6
6
5
5
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Hersteller
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Bilder

Produktnummer ABIN2660471
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2660472 BCA PerCP-Cy5.5 Rat IgG1 kappa Anmelden zum Anzeigen MP6-XT22 11

General

Antigen Tumor Necrosis Factor (TNF) Antikörper
Reaktivität Maus
(1259), (464), (359), (145), (136), (119), (119), (63), (55), (41), (29), (18), (14), (12), (9), (7), (6), (4), (4), (4), (4), (2), (1), (1), (1), (1)
Wirt Ratte
(942), (521), (185), (49), (10), (9), (7), (6), (4), (3), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser Tumor Necrosis Factor Antikörper ist konjugiert mit PerCP-Cy5.5
(169), (100), (78), (50), (32), (30), (28), (27), (26), (25), (25), (25), (25), (25), (24), (24), (24), (23), (13), (9), (8), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Biochemical Assay (BCA)
(888), (860), (633), (323), (287), (230), (221), (191), (139), (118), (97), (69), (30), (29), (26), (22), (20), (18), (14), (9), (8), (7), (6), (6), (6), (6), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 11 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-Tumor Necrosis Factor Antikörper

Target Details Tumor Necrosis Factor Anwendungsinformationen Handhabung Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471) Bilder
Reinigung The antibody was purified by affinity chromatography, and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.
Klon MP6-XT22
Isotyp IgG1 kappa

Target Details Tumor Necrosis Factor

Produktdetails anti-Tumor Necrosis Factor Antikörper Anwendungsinformationen Handhabung Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471) Bilder zurück nach oben
Antigen
Andere Bezeichnung TNF-alpha (TNF Antibody Abstract)
Hintergrund TNF-α is secreted by macrophages, monocytes, neutrophils, T-cells (principally CD4+), and NK-cells. Many transformed cell lines also secrete TNF-α. Monomeric mouse TNF-α is a 156 amino acid protein (N-glycosylated) with a reported molecular weight of 17.5 kD. TNF-α forms multimeric complexes, stable trimers are most common in solution. A 26 kD membrane form of TNF-α has also been described. TNF-α binding to surface receptors elicits a wide array of biologic activities including: cytolysis and cytostasis of many tumor cell lines in vitro, hemorrhagic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Forschungsgebiet Inflammation, Cancer, Virology
Pathways NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus

Anwendungsinformationen

Produktdetails anti-Tumor Necrosis Factor Antikörper Target Details Tumor Necrosis Factor Handhabung Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-Tumor Necrosis Factor Antikörper Target Details Tumor Necrosis Factor Anwendungsinformationen Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471) Bilder zurück nach oben
Konzentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.

Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471)

Produktdetails anti-Tumor Necrosis Factor Antikörper Target Details Tumor Necrosis Factor Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Via, Shustov, Rus, Lang, Nguyen, Finkelman: "In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 12, pp. 6821-6, 2001

Infante-Duarte, Horton, Byrne, Kamradt: "Microbial lipopeptides induce the production of IL-17 in Th cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6107-15, 2000

Jacobs, Brown, Allie, Gulert, Ryffel: "Increased resistance to mycobacterial infection in the absence of interleukin-10." in: Immunology, Vol. 100, Issue 4, pp. 494-501, 2000

Williams, Marinova-Mutafchieva, Feldmann, Maini: "Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7240-5, 2000

Marinova-Mutafchieva, Williams, Mason, Mauri, Feldmann, Maini: "Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA)." in: Clinical and experimental immunology, Vol. 107, Issue 3, pp. 507-12, 1997

Mo, Sarawar, Doherty: "Induction of cytokines in mice with parainfluenza pneumonia." in: Journal of virology, Vol. 69, Issue 2, pp. 1288-91, 1995

Sarawar, Sangster, Coffman, Doherty: "Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 3, pp. 1246-53, 1994

Tracey, Cerami: "Tumor necrosis factor: an updated review of its biology." in: Critical care medicine, Vol. 21, Issue 10 Suppl, pp. S415-22, 1993

Abrams, Roncarolo, Yssel, Andersson, Gleich, Silver: "Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples." in: Immunological reviews, Vol. 127, Issue 9-10, pp. 5-24, 1992

Beutler, Cerami: "The biology of cachectin/TNF--a primary mediator of the host response." in: Annual review of immunology, Vol. 7, pp. 625-55, 1989

Beutler, Cerami: "Tumor necrosis, cachexia, shock, and inflammation: a common mediator." in: Annual review of biochemistry, Vol. 57, pp. 505-18, 1988

Bilder

Produktdetails anti-Tumor Necrosis Factor Antikörper Target Details Tumor Necrosis Factor Anwendungsinformationen Handhabung Referenzen für anti-Tumor Necrosis Factor Antikörper (ABIN2660471) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor (TNF) antibody (PerCP-Cy5.5) (ABIN2660471) anti-Tumor Necrosis Factor (TNF) antibody (PerCP-Cy5.5)
Flow Cytometry (FACS) image for anti-Tumor Necrosis Factor (TNF) antibody (PerCP-Cy5.5) (ABIN2660471) anti-Tumor Necrosis Factor (TNF) antibody (PerCP-Cy5.5) (Image 2)