TRAF6 Proteine (TRAF6)

Bezeichnung:
TNF Receptor-Associated Factor 6 Proteine (TRAF6)
Auf www.antikoerper-online.de finden Sie aktuell 14 TNF Receptor-Associated Factor 6 (TRAF6) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TRAF6 Antikörper (157) und TRAF6 Kits (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 210 TRAF6 Produkte verfügbar.
Synonyme:
2310003F17Rik, AI851288, C630032O20Rik, CG10961, Dmel\\CG10961, dtraf2, dTRAF6, fi15f02, GB10539, MGC:3310, RNF85, TRAF, Traf2, TRAF6, wu:fi15f02, xtraf6, zgc:63704
alle Proteine anzeigen Gen GeneID UniProt
TRAF6 22034 P70196
TRAF6 7189 Q9Y4K3
TRAF6 311245 B5DF45

Weitere Synonyme anzeigen

TRAF6 Proteine (TRAF6) nach Spezies

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Am meisten referenzierte TRAF6 Proteine

  1. Human TRAF6 Protein expressed in HEK-293 Cells - ABIN2734115 : Tikhanovich, Kuravi, Artigues, Villar, Dorko, Nawabi, Roberts, Weinman: Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. in The Journal of biological chemistry 2015 (PubMed)

  2. Human TRAF6 Protein expressed in Wheat germ - ABIN1323514 : Nakada, Tai, Panier, Al-Hakim, Iemura, Juang, ODonnell, Kumakubo, Munro, Sicheri, Gingras, Natsume, Suda, Durocher: Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. in Nature 2010 (PubMed)

Weitere Proteine zu TRAF6 Interaktionspartnern

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 6 (TRAF6) Interaktionspartner

  1. we found that reactive oxygen species-induced autophagy acts as a negative feedback regulator of JNK (zeige MAPK8 Proteine) activity by dissociating Atg9 (zeige ATG9A Proteine)/mAtg9 (zeige ATG9A Proteine) from dTRAF2/TRAF6 in Drosophila.

  2. null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and antimicrobial gene transcription against microbial infection were severely impaired

Mouse (Murine) TNF Receptor-Associated Factor 6 (TRAF6) Interaktionspartner

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine)-regulated apoptosis and the p53 (zeige TP53 Proteine)/PCNA (zeige PCNA Proteine)- and ATM (zeige ATM Proteine)/ATR-Chk1 (zeige CHEK1 Proteine)/2-controlled DNA-damage response pathways.

  2. TRAF6 prevents the mitochondrial translocation of p53 (zeige TP53 Proteine) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (zeige TP53 Proteine) in cytosol.

  3. TRAF6 mediates lysine-63 ubiquitination within the SH2 domain of STAT3 (zeige STAT3 Proteine), which is an essential step for STAT3 (zeige STAT3 Proteine) membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone

  4. this study shows that an interaction of TRAF6 with cullin-5 (zeige CUL5 Proteine) promotes TRAF6 polyubiquitination and lipopolysaccharide signaling

  5. Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors

  6. Data (including data from studies using knockout mice) suggest that RANKL (zeige TNFSF11 Proteine) enhances TNF (zeige TNF Proteine)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 by degrading Traf3 (zeige TRAF3 Proteine), a known inhibitor of osteoclastogenesis. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); TNF (zeige TNF Proteine) = tumor necrosis factor (zeige TNF Proteine); Traf (zeige TRAF1 Proteine) = TNF (zeige TNF Proteine) receptor-associated factor)

  7. the SH3 domain of NOSTRIN (zeige NOSTRIN Proteine) is involved in the NOSTRIN (zeige NOSTRIN Proteine)-TRAF6 interaction and is required for NOSTRIN (zeige NOSTRIN Proteine)-induced down-regulation of endothelial cell proteins

  8. this study shows that TRAF6 overexpression in hematopoietic stem/progenitor cells results in impaired hematopoiesis and bone marrow failure

  9. TRAF6 and H2AX (zeige H2AFX Proteine) overexpression and gammaH2AX (zeige H2AFX Proteine)-mediated HIF1alpha (zeige HIF1A Proteine) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (zeige HIF1A Proteine)-driven tumorigenesis, glycolysis and metastasis.

  10. By studying the response of T (zeige IFT122 Proteine)raf6(+/+) and Traf6(-/-)mouse embryonic fibroblasts to S. typhimurium infection, this study showed that TRAF6 promoted apoptosis by increasing reactive oxygen species accumulation, which led to increased Bax/Bcl-2 ratio, Bax recruitment to mitochondrial membrane, and release of Cyt c into the cytoplasm.

Zebrafish TNF Receptor-Associated Factor 6 (TRAF6) Interaktionspartner

  1. we have now analyzed the in vivo function of Traf6 in the innate immune response without interference of adaptive immunity

  2. Full-length traf6 was functionally characterized.

Human TNF Receptor-Associated Factor 6 (TRAF6) Interaktionspartner

  1. TRAF6 prevents the mitochondrial translocation of p53 (zeige TP53 Proteine) and spontaneous apoptosis by promoting lysine63-linked ubiquitination of p53 (zeige TP53 Proteine) in cytosol.

  2. The E3 ligase TRAF6 binds to DCP1a (zeige DCP1A Proteine) and indirectly regulates DCP1a (zeige DCP1A Proteine) phosphorylation, expression of decapping factors, and gene-specific mRNA decay.

  3. Study showed that patients without a history of atrial fibrillation who develop postoperative atrial fibrillation have a higher percentage of left atrial fibrosis, increased expression of TRAF6, higher serum Ang II (zeige AGT Proteine) levels, and changes in the activities of the MAPKs/TGF-beta1 (zeige TGFB1 Proteine)/TRAF6 pathway.

  4. Low TRAF6 expression is associated with graft-versus-host disease.

  5. Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors

  6. Results suggest that overexpression of miR (zeige MLXIP Proteine)-146a could promote IDD (zeige COL9A3 Proteine) through the TRAF (zeige TRAF1 Proteine)/NF-kappaB (zeige NFKB1 Proteine) pathway.

  7. TRAF6 and H2AX (zeige H2AFX Proteine) overexpression and gammaH2AX (zeige H2AFX Proteine)-mediated HIF1alpha (zeige HIF1A Proteine) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (zeige HIF1A Proteine)-driven tumorigenesis, glycolysis and metastasis.

  8. These findings show that SopB (zeige IFT122 Proteine) suppresses host cell apoptosis by binding to TRAF6 and preventing mitochondrial reactive oxygen species generation.

  9. HCV infection suppressed the host innate immune response through the induction of autophagic degradation of TRAF6. This finding provided important information for further understanding how HCV evades host immunity to establish persistence

  10. Vav3 (zeige VAV3 Proteine) is a novel TRAF6 interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.

TRAF6 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported.

Alternative names and synonyms associated with TRAF6

  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6-b)
  • TNF-receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6 (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (traf6)
  • TNF receptor-associated factor 6 (traf6)
  • TNF receptor-associated factor 6 (Traf6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6)
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase (Traf6)
  • 2310003F17Rik Protein
  • AI851288 Protein
  • C630032O20Rik Protein
  • CG10961 Protein
  • Dmel\\CG10961 Protein
  • dtraf2 Protein
  • dTRAF6 Protein
  • fi15f02 Protein
  • GB10539 Protein
  • MGC:3310 Protein
  • RNF85 Protein
  • TRAF Protein
  • Traf2 Protein
  • TRAF6 Protein
  • wu:fi15f02 Protein
  • xtraf6 Protein
  • zgc:63704 Protein

Bezeichner auf Proteinebene für TRAF6

TNF receptor-associated factor 6-B , E3 ubiquitin-protein ligase TRAF6 , CG10961-PA , TNF-receptor-associated factor 2 , Traf6-PA , TNF receptor-associated factor 6 , TNF receptor-associated factor 6-like , RING finger protein 85 , interleukin-1 signal transducer , TNF-receptor associated factor 6

GENE ID SPEZIES
444777 Xenopus laevis
31746 Drosophila melanogaster
423163 Gallus gallus
451702 Pan troglodytes
493524 Xenopus (Silurana) tropicalis
551819 Apis mellifera
100010055 Monodelphis domestica
100174890 Gasterosteus aculeatus
100395364 Callithrix jacchus
100449432 Pongo abelii
100510771 Anolis carolinensis
100544809 Meleagris gallopavo
100595327 Nomascus leucogenys
22034 Mus musculus
539124 Bos taurus
554561 Danio rerio
7189 Homo sapiens
311245 Rattus norvegicus
100688110 Canis lupus familiaris
396629 Sus scrofa
716907 Macaca mulatta
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