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SQSTM1 Proteine (SQSTM1)

Bezeichnung:
Sequestosome 1 Proteine (SQSTM1)
Auf www.antikoerper-online.de finden Sie aktuell 14 Sequestosome 1 (SQSTM1) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SQSTM1 Antikörper (301) und SQSTM1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 337 SQSTM1 Produkte verfügbar.
Synonyme:
A170, MGC79491, OSF-6, Osi, OSIL, p60, p62, p62B, PDB3, sb:cb621, sqstm1, STAP, zgc:85784, ZIP, ZIP3
alle Proteine anzeigen Gen GeneID UniProt
SQSTM1 8878 Q13501
SQSTM1 18412 Q64337
SQSTM1 113894 O08623

Weitere Synonyme anzeigen

SQSTM1 Proteine (SQSTM1) nach Spezies

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Am meisten referenzierte SQSTM1 Proteine

  1. Human SQSTM1 Protein expressed in Escherichia coli (E. coli) - ABIN666979 : Falchetti, Di Stefano, Marini, Del Monte, Mavilia, Strigoli, De Feo, Isaia, Masi, Amedei, Cioppi, Ghinoi, Bongi, Di Fede, Sferrazza, Rini, Melchiorre, Matucci-Cerinic, Brandi: Two novel mutations at exon 8 of the Sequestosome 1 (SQSTM1) gene in an Italian series of patients affected by Paget's disease of bone (PDB). in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)

Weitere Proteine zu SQSTM1 Interaktionspartnern

Human Sequestosome 1 (SQSTM1) Interaktionspartner

  1. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.

  2. siRNA-mediated knockdown of p62 clearly increased the efficiency of transfection of murine embryonic stem (mES) cells and human HeLa cells. These data indicate that p62 acts as a key regulator of gene delivery.

  3. These studies suggest that p62 is involved in the genesis of nuclear factor kappaB-induced proinflammatory and prolabor mediators.

  4. In this review, we discuss p62-mediated signaling pathways and their roles in liver pathophysiology, especially nonalcoholic steatohepatitis and hepatocellular carcinoma

  5. findings expand the SQSTM1-associated phenotypic spectrum and lend further support to the concept of disturbed selective autophagy pathways in neurodegenerative diseases

  6. Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation

  7. Results demonstrate that p62 (zeige GTF2H1 Proteine) facilitates activation of NRF2 (zeige GABPA Proteine) and mTORC1 and is essential for hepatocellular carcinomas (HCC (zeige FAM126A Proteine)) initiation. High levels of p62 accumulation in non-tumor liver tissue in early-stage HCC patients.

  8. Results show that Nrf2 (zeige GABPA Proteine) prevents TM-induced apoptotic cell death and that TM promotes p62 (zeige GTF2H1 Proteine)-dependent autophagic Keap1 (zeige KEAP1 Proteine) degradation, leading to Nrf2 (zeige GABPA Proteine) activation. In addition, we identified that p62 (zeige GTF2H1 Proteine) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (zeige GABPA Proteine) activation.

  9. Spinal stenosis emerges as a prominent phenotype in SQSTM1 P392L-positive men with aging

  10. p62 is a crucial positive regulator of HIF1alpha, which is a facilitating factor in p62-enhanced tumorigenesis.

Mouse (Murine) Sequestosome 1 (SQSTM1) Interaktionspartner

  1. two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1 (zeige SOD1 Proteine)-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system.

  2. These results demonstrated that p62-dependent mitophagy has an immunosuppressive role to innate immune response and might serve as a potential immunomodulatory target for inflammation-associated diseases.

  3. results indicate that autophagy is important for the removal of excess Endoplasmic Reticulum and hepatic CYP enzymes in mouse livers, a process associated with the autophagy receptor protein p62.

  4. p62 (zeige GTF2H1 Proteine) reduces UVB-induced apoptosis by modulating intrinsic apoptotic signaling through Src (zeige SRC Proteine) phosphorylation.

  5. Our results indicate that JEV replication is impaired in p62-deficient MEFs, suggesting that p62 positively regulates JEV replication in host cells.

  6. Results demonstrate that p62 (zeige GTF2H1 Proteine) facilitates activation of NRF2 (zeige NFE2L2 Proteine) and mTORC1 and is essential for hepatocellular carcinomas (HCC (zeige FAM126A Proteine)) initiation.

  7. p62 may be a crucial mediator for the mitochondrial apoptosis pathway in Monosodium Urate crystal-induced inflammation, which is linked to the acute inflammatory response during the early phase of gout.

  8. Results show that Nrf2 (zeige NFE2L2 Proteine) prevents TM-induced apoptotic cell death and that TM promotes p62 (zeige GTF2H1 Proteine)-dependent autophagic Keap1 (zeige KEAP1 Proteine) degradation, leading to Nrf2 (zeige NFE2L2 Proteine) activation. In addition, we identified that p62 (zeige GTF2H1 Proteine) is essential to protect cells against TM-mediated oxidative damage through Nrf2 (zeige NFE2L2 Proteine) activation.

  9. the molecular basis for the escape of TBC1D25 (zeige TBC1D25 Proteine) from autophagic degradation by performing a chimeric analysis between TBC1D25 (zeige TBC1D25 Proteine) and SQSTM1/p62, was investigated.

  10. p62 (zeige GTF2H1 Proteine) are subjected to parkin (zeige PARK2 Proteine) mediated proteasomal degradation

Zebrafish Sequestosome 1 (SQSTM1) Interaktionspartner

  1. Loss-of-function of SQSTM1 may cause phenotypic features characterized by locomotor deficits and motor neuron axonal defects that are associated with a misregulation of autophagic processes.

SQSTM1 Protein Überblick

Protein Überblick

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Alternative names and synonyms associated with SQSTM1

  • sequestosome 1 (SQSTM1)
  • sequestosome 1 (LOC100342157)
  • sqstm1 protein (sqstm1)
  • sequestosome 1 (Sqstm1)
  • sequestosome 1 (sqstm1)
  • A170 Protein
  • MGC79491 Protein
  • OSF-6 Protein
  • Osi Protein
  • OSIL Protein
  • p60 Protein
  • p62 Protein
  • p62B Protein
  • PDB3 Protein
  • sb:cb621 Protein
  • sqstm1 Protein
  • STAP Protein
  • zgc:85784 Protein
  • ZIP Protein
  • ZIP3 Protein

Bezeichner auf Proteinebene für Sequestosome 1 Proteine (SQSTM1)

sequestosome 1 , sequestosome-1 , sequestosome-1-like , sqstm1 protein , EBI3-associated protein of 60 kDa , EBI3-associated protein p60 , EBIAP , oxidative stress induced like , phosphotyrosine independent ligand for the Lck SH2 domain p62 , phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa , ubiquitin-binding protein p62 , STONE14 , oxidative stress induced , PKC-zeta-interacting protein , protein kinase C-zeta-interacting protein

GENE ID SPEZIES
462333 Pan troglodytes
705481 Macaca mulatta
770805 Gallus gallus
100135450 Ovis aries
100342157 Oryctolagus cuniculus
100385650 Callithrix jacchus
493277 Xenopus (Silurana) tropicalis
100067231 Equus caballus
8878 Homo sapiens
18412 Mus musculus
113894 Rattus norvegicus
406452 Danio rerio
379610 Xenopus laevis
338045 Bos taurus
481459 Canis lupus familiaris
100172461 Pongo abelii
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