RANK Proteine (CD265)

RANK Proteine (CD265)
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alle Proteine anzeigen Gen GeneID UniProt
CD265 21934 O35305
CD265 8792 Q9Y6Q6
Ratte CD265 CD265 498206  

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Am meisten referenzierte RANK Proteine

  1. Human RANK Protein expressed in HEK-293 - ABIN2666569 : Anderson, Maraskovsky, Billingsley, Dougall, Tometsko, Roux, Teepe, DuBose, Cosman, Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. in Nature 1997 (PubMed)
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Weitere Proteine zu RANK Interaktionspartnern

Mouse (Murine) RANK (CD265) Interaktionspartner

  1. Data suggest that mutations at position I248 in DE-loop of murine RANKL (zeige TNFSF11 Proteine) have effects on interaction of RANKL (zeige TNFSF11 Proteine) with RANK and on subsequent activation of osteoclastogenesis by this hetero-multimer. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); RANK = tumor necrosis factor (zeige TNF Proteine) receptor superfamily, member 11a protein)

  2. The persistence of bone erosion and synovial osteoclasts in Rank-deficient mice, and the ability of TNF (zeige TNF Proteine)/IL-6 (zeige IL6 Proteine) to induce osteoclastogenesis, suggest that more than one cytokine pathway exists to generate these bone-resorbing cells in inflamed joints.

  3. Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (zeige CA2 Proteine)+)storage and SERCA (zeige ATP2A3 Proteine) activity, ultimately affecting denervated skeletal muscle function.

  4. present study shows that ginsenoside Rg3 protects against LPS (zeige TLR4 Proteine)-induced acute lung injury through inactivating the NF-kappaB (zeige NFKB1 Proteine) signaling

  5. In palmatine-treated mice, RANKL (zeige TNFSF11 Proteine) and OPG (zeige TNFSF11 Proteine) expression decreased. In the culture supernatant of MC3T3-E1 cells, RANKL (zeige TNFSF11 Proteine) and OPG (zeige TNFSF11 Proteine) levels were significantly reduced by palmatine addition.

  6. Results show that moderate increases in affinity for RANK lead to a substantial augmentation of osteoclast formation, signaling, and bone resorption suggesting a biphasic relationship between RANKL (zeige TNFSF11 Proteine)/RANK affinity and osteoclastogenic capacity.

  7. Dissection of the mechanism by which this occurs indicates that mCripto-1 activates receptor activator NF-kappaB (zeige NFKB1 Proteine)/receptor activator NF-kappaB (zeige NFKB1 Proteine) ligand, and NF-kappaB (zeige NFKB1 Proteine) signaling pathways.

  8. We also show that R-spondin1 (zeige RSPO1 Proteine) is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (zeige WNT2 Proteine) response and mammary cell expansion

  9. findings have uncovered a tumorigenic role for RANKL (zeige TNFSF11 Proteine)/RANK in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment of this understudied head and neck cancer

  10. results indicate that the RANK IVVY motif cooperates with the TRAF (zeige TRAF1 Proteine)-binding motifs to promote osteoclastogenesis, which provides novel insights into the molecular mechanism of RANK signaling in osteoclastogenesis.

Human RANK (CD265) Interaktionspartner

  1. RANK/RANKL (zeige TNFSF11 Proteine) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin (zeige TNFRSF11B Proteine) to prevent bone metastasis.

  2. In histologically normal tissue of BRCA1-mutation carriers and showed that RANK(+) cells are highly proliferative, have grossly aberrant DNA repair and bear a molecular signature similar to that of basal-like breast cancer.

  3. In this review, we will provide a summary of the biological functions of RANK signaling pathway (receptor activator of nuclear factor kappaB ligand RANKL (zeige TNFSF11 Proteine) and its receptor RANK ) and downstream pathways in bone remodeling, immunity and epithelial homeostasis, with a particular emphasis on cancer

  4. Our results suggest that the polymorphism of the RANKL (zeige TNFSF11 Proteine), RANK, and OPG (zeige TNFRSF11B Proteine) genes does not make a significant genetic contribution to heel ultrasound measurements in a population of young Caucasian adults. Further studies replicating the results in independent populations are needed to support these initial findings.

  5. Vav3 (zeige VAV3 Proteine) is a novel TRAF6 (zeige TRAF6 Proteine) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.

  6. OPG (zeige TNFRSF11B Proteine) rs2073618, RANK rs75404003, and RANKL (zeige TNFSF11 Proteine) rs9594782 single nucleotide poymorphisms may predispose LVH in thalassemia patients.

  7. Twenty-one single-nucleotide polymorphisms (SNPs) of TNFSF11, TNFRSF11A, and TNFRSF11B were genotyped. This study suggests that TNFRSF11B but not TNFSF11 and TNFRSF11A genetic polymorphisms are associated with Type 2 Diabetes Mellitus in Southern Han Chinese women.

  8. the OPG/RANKL (zeige TNFSF11 Proteine)/RANK system might be directly influenced by genetic variants of NOTCH1 (zeige NOTCH1 Proteine) in aortic valve calcification.

  9. Postmenopausal women with Rheumatoid Arthritis, carrying either the RANKL (zeige TNFSF11 Proteine)-290T allele or possessing the RANK 575CC genotype were more likely to develop osteoporosis.

  10. The RANK/RANKL (zeige TNFSF11 Proteine) system induces chemoresistance.

RANK (CD265) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.

Alternative names and synonyms associated with RANK (CD265)

  • tumor necrosis factor receptor superfamily, member 11a (Tnfrsf11a)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (TNFRSF11A)
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator (Tnfrsf11a)
  • CD265 Protein
  • FEO Protein
  • LOH18CR1 Protein
  • Ly109 Protein
  • mRANK Protein
  • ODFR Protein
  • OFE Protein
  • OPTB7 Protein
  • OSTS Protein
  • PDB2 Protein
  • RANK Protein
  • RGD1563614 Protein
  • TRANCE-R Protein
  • TRANCER Protein

Bezeichner auf Proteinebene für RANK Proteine (CD265)

osteoclast differentiation factor receptor , receptor activator of NF-KB , receptor activator of NF-kappaB , tumor necrosis factor receptor superfamily member 11A , loss of heterozygosity, 18, chromosomal region 1 , receptor activator of nuclear factor-kappa B

21934 Mus musculus
8792 Homo sapiens
498206 Rattus norvegicus
483957 Canis lupus familiaris
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