anti-Maus p65 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended p65 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Nuclear Factor-KB P65 (NFkBP65) Antikörper
  • NFKB3
  • p65
  • NFkB
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • RELA
  • Rela
Epitop
pSer536
129
84
68
64
50
45
41
39
38
38
27
26
25
23
18
18
17
16
15
15
14
13
13
12
11
9
8
7
6
6
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
1169
677
520
72
56
55
30
25
25
23
13
8
8
6
4
2
1
1
Wirt
Kaninchen
1008
140
25
11
1
1
Klonalität
Polyklonal
Konjugat
Dieser p65 Antikörper ist unkonjugiert
30
28
22
21
20
19
16
14
14
14
13
10
10
8
8
8
8
8
8
4
4
3
3
3
2
2
2
2
2
2
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
844
443
324
259
207
163
107
104
89
28
19
18
15
12
12
8
6
6
5
5
4
2
2
2
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN730528
$ 329.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN700555 IF (p) IHC (p) WB Rabbit IgG AA 250-300, pSer276 Anmelden zum Anzeigen Polyclonal 2
1 ABIN668961 FACS IF (p) IHC (p) WB Rabbit IgG AA 50-100 Anmelden zum Anzeigen Polyclonal 15
1 ABIN747038 IF (p) IHC (p) WB Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN712886 IF (p) IHC (p) WB Rabbit IgG pThr254 Anmelden zum Anzeigen Polyclonal
1 ABIN2814971 IF (p) Alexa Fluor 594 Rabbit IgG AA 440-490, pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN747044 IF (p) Cy7 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN747045 IF (p) FITC Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN747043 IF (p) Cy5.5 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN747042 IF (p) Cy5 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN747041 IF (p) Cy3 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN876299 IF (p) Alexa Fluor 350 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN876302 IF (p) Alexa Fluor 647 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN876301 IF (p) Alexa Fluor 555 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN876303 IF (p) Alexa Fluor 488 Rabbit IgG pSer468 Anmelden zum Anzeigen Polyclonal
1 ABIN2808014 IF (p) Cy7 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal
1 ABIN2809128 IF (p) Alexa Fluor 350 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal
1 ABIN2809258 IF (p) Alexa Fluor 555 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal
1 ABIN2807768 IF (p) Alexa Fluor 647 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal
1 ABIN2807830 IF (p) Cy3 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal
1 ABIN2807952 IF (p) Cy5.5 Rabbit IgG AA 130-180 Anmelden zum Anzeigen Polyclonal

General

Antigen Nuclear Factor-KB P65 (NFkBP65) Antikörper
Epitop pSer536
(129), (84), (68), (64), (50), (45), (41), (39), (38), (38), (27), (26), (25), (23), (18), (18), (17), (16), (15), (15), (14), (13), (13), (12), (11), (9), (8), (7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(1169), (677), (520), (72), (56), (55), (30), (25), (25), (23), (13), (8), (8), (6), (4), (2), (1), (1)
Wirt Kaninchen
(1008), (140), (25), (11), (1), (1)
Klonalität
Polyklonal
Konjugat Dieser p65 Antikörper ist unkonjugiert
(30), (28), (22), (21), (20), (19), (16), (14), (14), (14), (13), (10), (10), (8), (8), (8), (8), (8), (8), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(844), (443), (324), (259), (207), (163), (107), (104), (89), (28), (19), (18), (15), (12), (12), (8), (6), (6), (5), (5), (4), (2), (2), (2), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-p65 Antikörper

Target Details p65 Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN730528) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human NFKBp65 around the phosphorylation site of(Ser536)
Isotyp IgG

Target Details p65

Produktdetails anti-p65 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN730528) Bilder zurück nach oben
Antigen
Andere Bezeichnung NFKB p65 (NFkBP65 Antibody Abstract)
Hintergrund

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).

Subcellular location: Cytoplasm, Nucleus

Synonyms: p65, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA

Gen-ID 5970
UniProt Q04206
Pathways NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-p65 Antikörper Target Details p65 Handhabung Referenzen für anti-p65 Antikörper (ABIN730528) Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Referenzen für anti-p65 Antikörper (ABIN730528) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-p65 Antikörper (ABIN730528)

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Fu, Shi, Song, Xia, Su, Liu, Song, Song: "Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/IκB/NF-κB signaling." in: Environmental toxicology and pharmacology, Vol. 41, pp. 241-50, 2016

Zhao, Zheng, Hu, Shen, Li: "Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway." in: Life sciences, Vol. 144, pp. 185-93, 2016

Zhang, Zhao, Yuan, Wu, Jiang, Luo, Zhao: "Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway." in: International immunopharmacology, Vol. 38, pp. 167-74, 2016

Gao, Guo, Wang, Lin, Yu, Sheng, Wu, Gong: "Indirubin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice through the inhibition of inflammation and the induction of Foxp3-expressing regulatory T cells." in: Acta histochemica, Vol. 118, Issue 6, pp. 606-14, 2016

Yan, Wu, Li, Meng, Dai, Zheng, Fu: "Cyanidin-3-O-glucoside attenuates acute lung injury in sepsis rats." in: The Journal of surgical research, Vol. 199, Issue 2, pp. 592-600, 2015

Zhao, Liu, Liu, Han, Zhao: "Betulin attenuates lung and liver injuries in sepsis." in: International immunopharmacology, Vol. 30, pp. 50-6, 2015

Bilder

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN730528) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Nuclear Factor-KB P65 (NFkBP65) (pSer536) antibody (ABIN730528) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-N...
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (pSer536) antibody (ABIN730528) Mouse spleen lysates probed with Rabbit Anti-NFKB p65(Ser536) Polyclonal Antibody, Un...
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (pSer536) antibody (ABIN730528) Mouse spleen lysates probed with Rabbit Anti-NFKB p65(Ser536) Polyclonal Antibody, Un...
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (pSer536) antibody (ABIN730528) Mouse lung lysates probed with Rabbit Anti-NFkB p65 (Ser536) Polyclonal Antibody, Unc...