anti-Hund p65 Antikörper für Immunohistochemistry

Recommended p65 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Nuclear Factor-KB P65 (NFkBP65) Antikörper
  • NFKB3
  • p65
  • NFkB
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • RELA
  • Rela
Epitop
Middle Region
129
85
68
64
50
45
41
39
38
38
27
26
25
23
18
18
17
16
15
15
14
13
13
12
11
9
8
7
6
5
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Human, Maus, Schwein, Ratte (Rattus)
1169
677
520
71
55
55
30
25
24
23
13
8
8
6
4
2
1
1
Wirt
Kaninchen
1008
140
25
11
1
1
Klonalität
Polyklonal
Konjugat
Dieser p65 Antikörper ist unkonjugiert
30
28
22
21
20
19
16
14
14
14
13
10
10
8
8
8
8
8
8
4
4
3
3
3
2
2
2
2
2
2
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
844
442
324
260
207
163
107
105
89
28
19
18
15
12
12
8
6
6
5
5
4
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2779331
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN209104 IF IHC ELISA WB Rabbit IgG AA 297-308 Anmelden zum Anzeigen Polyclonal

General

Antigen Nuclear Factor-KB P65 (NFkBP65) Antikörper
Epitop Middle Region
(129), (85), (68), (64), (50), (45), (41), (39), (38), (38), (27), (26), (25), (23), (18), (18), (17), (16), (15), (15), (14), (13), (13), (12), (11), (9), (8), (7), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Human, Maus, Schwein, Ratte (Rattus)
(1169), (677), (520), (71), (55), (55), (30), (25), (24), (23), (13), (8), (8), (6), (4), (2), (1), (1)
Wirt Kaninchen
(1008), (140), (25), (11), (1), (1)
Klonalität
Polyklonal
Konjugat Dieser p65 Antikörper ist unkonjugiert
(30), (28), (22), (21), (20), (19), (16), (14), (14), (14), (13), (10), (10), (8), (8), (8), (8), (8), (8), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(844), (442), (324), (260), (207), (163), (107), (105), (89), (28), (19), (18), (15), (12), (12), (8), (6), (6), (5), (5), (4), (2), (2), (2), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-p65 Antikörper

Target Details p65 Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN2779331) Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN982837.
Sequenz LVTGAQRPPD PAPAPLGAPG LPNGLLSGDE DFSSIADMDF SALLSQISS
Homologie Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against RELA. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human RELA

Target Details p65

Produktdetails anti-p65 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN2779331) Bilder zurück nach oben
Antigen
Andere Bezeichnung RELA (NFkBP65 Antibody Abstract)
Hintergrund P65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1760 M62399.1 8-1767
Alias Symbols: MGC131774, NFKB3, p65
Protein Interaction Partner: GAN, CCND1, ABCA1, UBC, TCF4, SRSF7, RELA, REL, PRKDC, PLG, PEX1, NFKB2, NFKB1, MUC3A, KRT5, REV1, TXN2, FBXW11, IL1RN, IKBKB, HSPA5, HDAC1, EP300, CREBBP, MAP3K8, CHEK1, CDKN2A, CDK4, SPATA31A3, POTEJ, POTEE, PIWIL4, DIS3L2, DCD, IKBKG, CHUK, PLA2G4A, ST
Protein Size: 551
Molekulargewicht 60 kDa
Gen-ID 5970
NCBI Accession NM_021975, NP_068810
UniProt Q04206
Pathways NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-p65 Antikörper Target Details p65 Handhabung Referenzen für anti-p65 Antikörper (ABIN2779331) Bilder zurück nach oben
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 551 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Referenzen für anti-p65 Antikörper (ABIN2779331) Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-p65 Antikörper (ABIN2779331)

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Wittwer, Schmitz: "NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 294-7, 2008

Bilder

Produktdetails anti-p65 Antikörper Target Details p65 Anwendungsinformationen Handhabung Referenzen für anti-p65 Antikörper (ABIN2779331) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (Middle Region) antibody (ABIN2779331) Host: Rabbit
Target Name: RELA
Sample Tissue: Human Adult Placenta
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (Middle Region) antibody (ABIN2779331) Host: Rabbit
Target Name: RELA
Sample Tissue: Human Fetal Heart
...
Western Blotting (WB) image for anti-Nuclear Factor-KB P65 (NFkBP65) (Middle Region) antibody (ABIN2779331) Host: Rabbit
Target Name: RELA
Sample Tissue: Human Fetal Lung
A...