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In cultured macrophages, LPS (zeige TLR4 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CPT1B Proteine) was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 Proteine) and IkappaBzeta activities.
Data show that I-kappa-B-zeta (IkappaBzeta) regulates macrophage interleukin-10 (zeige IL10 Proteine) (IL_10) expression by directly activated the Il-10 (zeige IL10 Proteine) promoter.
A possible important role of Nfkbiz in modulating the progression of inflammatory diseases in which IFN-gamma (zeige IFNG Proteine) and IL-1 (zeige IL1A Proteine) are abundant.
Nfkbiz-/- keratinocytes were hypoproliferative. In skin from Nfkbiz-/- mice, the expression of the keratinocyte differentiation markers K10 (zeige KRT10 Proteine) and filaggrin (zeige FLG Proteine) were reduced, although that of K14 (zeige KRT14 Proteine) was unchanged.
These data reveal a previously unappreciated role for IkappaB-zeta in IFN-gamma (zeige IFNG Proteine) production in T cells and the immunoregulatory function of T regulatory cells.
The pyrimidine-rich IkappaBzeta-responsive site plays an essential role in productive interaction of IkappaBzeta with the p50 (zeige LSP1 Proteine)-DNA complex.
IkappaB-zeta regulates TLR-mediated CSR by inducing AID
The IkappaB-zeta-Akirin2 (zeige AKIRIN2 Proteine)-BAF60 complex physically links the NF-kappaB (zeige NFKB1 Proteine) and SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) complexes in innate immune cell activation.
The IkappaB-zeta-deficient B cells exhibited impaired proliferation and enhanced up-regulation of CD86 (zeige CD86 Proteine) following stimulation of TLR9 (zeige TLR9 Proteine), but not the BCR (zeige BCR Proteine), indicating critical roles for IkappaB-zeta in TLR signaling in B cells.
IkappaBzeta-deficient mice showed significantly impaired CCL2 (zeige CCL2 Proteine) secretion.
a specific IL-17A (zeige IL17A Proteine)-induced gene, NFKBIZ, which encodes IkappaB-zeta, a transcriptional regulator for NF-kappaB (zeige NFKB1 Proteine), was demonstrated to have a significant role for IL-17A (zeige IL17A Proteine)-induced gene expression.
In cultured macrophages, LPS (zeige IRF6 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CCL2 Proteine) was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 Proteine) and IkappaBzeta activities.
IkappaB-zeta regulates human monocyte pro-inflammatory responses induced by Streptococcus pneumoniae.
TNF-alpha (zeige TNF Proteine)- and IL-17A (zeige IL17A Proteine) mediate synergistic induction of DEFB4 (zeige DEFB104A Proteine) gene expression in human keratinocytes through IkappaBzeta
We propose a previously unappreciated role of IkappaBzeta in the inflammatory micromilieu as well as progression in glioma
These results indicate that the LPS (zeige IRF6 Proteine)/IL-1beta (zeige IL1B Proteine)-MyD88 (zeige MYD88 Proteine) axis plays a crucial role for stabilization of IkappaB-zeta mRNA.
Interferon-gamma (IFN-gamma (zeige IFNG Proteine)) interferes with the IL-1 (zeige IL1A Proteine)/IKB-zeta axis in beta-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFN-gamma (zeige IFNG Proteine) and IL-22 (zeige IL22 Proteine).
NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b (zeige IL1B Proteine)-induced IL-6 (zeige IL6 Proteine) and GMCSF (zeige CSF2 Proteine).
IkappaBzeta functions as an important regulator of IFN-gamma (zeige IFNG Proteine) in human NK cells
NF-kappaB (zeige NFKB1 Proteine)-binding cofactor inhibitor of NF-kappaB (zeige NFKB1 Proteine)-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax (zeige CNTN2 Proteine) transactivates the IkappaB-zeta gene, mainly through NF-kappaB (zeige NFKB1 Proteine).
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
, NF-kappa-B inhibitor zeta
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
, molecule associated with ankyrin repeats induced by lipopolysaccharide
, NF-kappa-B inhibitor zeta-like
, IL-1 inducible nuclear ankyrin-repeat protein
, molecule possessing ankyrin repeats induced by lipopolysaccharide
, molecule possessing ankyrin-repeats induced by lipopolysaccharide
, Ikappa B-zeta variant 3
, molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse