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report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB (zeige NFKB1 ELISA Kits) signaling nodes TRAF2 (zeige TRAF2 ELISA Kits), TRAF3 (zeige TRAF3 ELISA Kits), IKKalpha (zeige CHUK ELISA Kits), NIK, and NF-kappaB2/p100 (zeige CUX1 ELISA Kits); also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 (zeige OLFM1 ELISA Kits) is a negative regulator of non-canonical NF-kappaB (zeige NFKB1 ELISA Kits) signalling by interacting with and inhibiting NIK. Thus, OLFM1 (zeige OLFM1 ELISA Kits) may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC (zeige CALR ELISA Kits)) patients.
Results reveal that endothelial Map4k4 (zeige MAP4K4 ELISA Kits) is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 (zeige MAP4K4 ELISA Kits) gene is associated with T2DM in a Chinese Han population, and MAP4K4 (zeige MAP4K4 ELISA Kits) gene variants may contribute to the risk toward the development of T2DM
The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM (zeige ODZ1 ELISA Kits) stage. high OTUD7B/low NIK index can predict an good prognosis.
Interactions between MAP4K4 (zeige MAP4K4 ELISA Kits) gene variants and environmental factors may contribute to MAP4K4 (zeige MAP4K4 ELISA Kits) attenuation in T cells, leading to non-obese T2D.
MAP4K4 (zeige MAP4K4 ELISA Kits) promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
miR (zeige MLXIP ELISA Kits)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4 (zeige MAP4K4 ELISA Kits)
The results of the present study suggested that inhibition of MAP4K4 (zeige MAP4K4 ELISA Kits) may be a therapeutic strategy for gastric cancer.
NIK (zeige MAP4K4 ELISA Kits) pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK (zeige MAP4K4 ELISA Kits) is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK (zeige MAP4K4 ELISA Kits), the authors could show in vivo that NIK (zeige MAP4K4 ELISA Kits) signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK (zeige MAP4K4 ELISA Kits) not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1 (zeige TNFRSF1A ELISA Kits)/RIP1 (zeige RALBP1 ELISA Kits)-dependent cell death independently of the alternative NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK (zeige MAP4K4 ELISA Kits)-induced alternative NF-kappaB (zeige NFKB1 ELISA Kits) signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK (zeige MAP4K4 ELISA Kits), and thus probably the noncanonical NF-kappaB (zeige NFKB1 ELISA Kits) pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 (zeige CD8A ELISA Kits) T cells after exposure to licensing stimuli.
Deletion of NIK (zeige MAP4K4 ELISA Kits) in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF (zeige TNFSF13B ELISA Kits).
We identify NIK (zeige MAP4K4 ELISA Kits) as a critical negative regulator of beta cell function, as pharmacological NIK (zeige MAP4K4 ELISA Kits) activation results in impaired glucose-stimulated insulin (zeige INS ELISA Kits) secretion in mouse and human islets.
the NIK (zeige MAP4K4 ELISA Kits) in thymic stroma may be critically involved in the differentiation of most NKT (zeige CTSL1 ELISA Kits) cell subsets (although the level of NIK (zeige MAP4K4 ELISA Kits) dependence may vary among the subsets), and also the NIK (zeige MAP4K4 ELISA Kits) in NKT (zeige CTSL1 ELISA Kits)-alphabeta cells may be dispensable for their effector function.
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14