Insulin Proteine (INS)

Bezeichnung:
Insulin Proteine (INS)
Auf www.antikoerper-online.de finden Sie aktuell 48 Insulin (INS) Proteine von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Insulin Antikörper (1086) und Insulin Kits (233) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1376 Insulin Produkte verfügbar.
Synonyme:
AA986540, IDDM2, ILPR, Ins-2, ins1, ins1-a, InsII, Insulin, IRDN, Mody, Mody4, MODY10, proinsulin, xins, zgc:109842
alle Proteine anzeigen Gen GeneID UniProt
INS 3630 P01308
INS 16334 P01326
INS 397415 P01315

Weitere Synonyme anzeigen

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Weitere Proteine zu Insulin Interaktionspartnern

Human Insulin (INS) Interaktionspartner

  1. Results indicate that insulin scores, but not glycemic scores, were positively associated with colorectal cancer (CRC (zeige CALR Proteine)) mortality.

  2. Data suggest that higher dietary intake of glucose, but not of fructose or of sucrose, is associated with insulin resistance; no associations were observed for high dietary intakes of glucose, fructose, or sucrose with loss of function of pancreatic beta-cells in secretion of insulin. This study was conducted in the Netherlands among patients newly diagnosed with prediabetes or type 2 diabetes.

  3. Higher maternal total n-3 PUFAs and specifically DHA levels during pregnancy are associated with higher childhood total-cholesterol, HDL (zeige HSD11B1 Proteine)-cholesterol and insulin levels.

  4. In pancreas sections from autoantibody-positive (Ab+) donors, insulin area and beta-cell mass are maintained before type 1 diabetes onset and that production of proinsulin increases. The pancreatic proinsulin-to-insulin area ratio was also increased in these donors with prediabetes

  5. microRNA-7 can differentiate human induced pluripotent stem cells into functional isletlike cell clusters secreting insulin in a short time.

  6. describe an alternative open reading frame within human insulin mRNA encoding a highly immunogenic polypeptide that is targeted by T cells in Type 1 Diabetes (T1D) patients. Cytotoxic T cells directed against the N-terminal peptide of this nonconventional product are present in the circulation of T1D patients, and such CD8 (zeige CD8A Proteine)(+) T cells are capable of killing human beta cells, and thereby may be diabetogenic.

  7. Insulin stimulation of Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) signaling in Cystic fibrosis (zeige S100A8 Proteine) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR (zeige CFTR Proteine).

  8. The activation mechanism of insulin, IF-I, and IGF-II upon binding to corresponding receptors using molecular dynamics simulations has been reported.

  9. These data implicate the insulin-FoxM1 (zeige FOXM1 Proteine)/PLK1/CENP-A (zeige CENPA Proteine) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  10. The reproducibility of proinsulin:C-peptide ratio (PI:C) benefits from the automated simultaneous determination of both hormones. HOMA2-IR-corrected PI:C may serve as a minimally invasive alternative to the more tedious hyperglycemic clamp test

Pig (Porcine) Insulin (INS) Interaktionspartner

  1. Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.

  2. The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 Proteine) activity and SFK signaling.

  3. PTPLAD1 (zeige PTPLAD1 Proteine) and AMPK (zeige PRKAA1 Proteine) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (zeige ATIC Proteine) later accumulates in the Golgi/endosome fraction.

  4. Pdx-1 (zeige PDX1 Proteine), MafA (zeige MAFA Proteine) and NeuroD1 (zeige NEUROD1 Proteine) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.

  5. The interplay of the adiponectin (zeige ADIPOQ Proteine) system, TNFalpha (zeige TNF Proteine) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (zeige PPARG Proteine), as well as on the activation of main insulin signaling pathways, is reported.

  6. Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.

  7. Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.

  8. Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.

  9. The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (zeige IGF1 Proteine) levels are less easily modified.

  10. insulin increased GCLc (zeige GCLC Proteine) promoter activity, which required a prerequisite increase or decrease in medium glucose

Cow (Bovine) Insulin (INS) Interaktionspartner

  1. Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period

  2. Differences between human and bovine insulin kinetics under shear

  3. increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction

  4. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (zeige LEP Proteine)-NPY (zeige NPY Proteine) and insulin signaling pathways.

  5. Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.

  6. Contains Binding kinetics for insulin binding

  7. Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (zeige VMP1 Proteine)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.

  8. Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.

  9. The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.

  10. In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.

Rabbit Insulin (INS) Interaktionspartner

  1. insulin supports early initiation of the mesodermal factor Brachyury (zeige TBX1 Proteine) and the signalling molecules Wnt3a (zeige WNT3A Proteine) and Wnt4 (zeige WNT4 Proteine) as well as the progression of mesoderm formation

  2. Data show that type 1 diabetic blastocyst did not express insulin mRNA.

Mouse (Murine) Insulin (INS) Interaktionspartner

  1. report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (zeige SOX2 Proteine)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification

  2. Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.

  3. Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.

  4. Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.

  5. have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function

  6. Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.

  7. Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.

  8. Data indicate that insulin/incomplete Freund's adjuvant (IFA) does not prevent but induces diabetes in RIP-CD80GP transgenic mice.

  9. RORalpha is a transcriptional activator of insulin.

  10. Mice deficient in coinhibitory PD-L1 (zeige CD274 Proteine) or PD-1 (zeige PDCD1 Proteine) molecules (PD-L1 (zeige CD274 Proteine)(-/-) and PD-1 (zeige PDCD1 Proteine)(-/-) mice), were used to study induction of preproinsulin (ppins)-specific CD8 (zeige CD8A Proteine) T-cell responses and experimental autoimmune diabetes.

Zebrafish Insulin (INS) Interaktionspartner

  1. Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.

  2. These findings suggest that GHRL (zeige GHRL Proteine) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (zeige GHSR Proteine) in the central nervous system and partly involved in carbohydrate-glycogen (zeige GYS2 Proteine) metabolism.

  3. Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.

Insulin (INS) Protein Überblick

Protein Überblick

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Insulin (INS)

  • insulin (ins)
  • insulin precursor (PIN)
  • insulin (INS)
  • insulin (Ins)
  • insulin II (Ins2)
  • insulin-like (LOC100060077)
  • preproinsulin (ins)
  • AA986540 Protein
  • IDDM2 Protein
  • ILPR Protein
  • Ins-2 Protein
  • ins1 Protein
  • ins1-a Protein
  • InsII Protein
  • Insulin Protein
  • IRDN Protein
  • Mody Protein
  • Mody4 Protein
  • MODY10 Protein
  • proinsulin Protein
  • xins Protein
  • zgc:109842 Protein

Bezeichner auf Proteinebene für Insulin Proteine (INS)

insulin I , insulin , preproinsulin , proinsulin , insulin-2 , insa

GENE ID SPEZIES
100101718 Xenopus (Silurana) tropicalis
100533403 Aplysia californica
3630 Homo sapiens
397415 Sus scrofa
280829 Bos taurus
100009181 Oryctolagus cuniculus
101684928 Mustela putorius furo
483665 Canis lupus familiaris
493804 Felis catus
100379579 Cavia porcellus
396145 Gallus gallus
101794427 Anas platyrhynchos
449570 Pan troglodytes
16334 Mus musculus
100060077 Equus caballus
30262 Danio rerio
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