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sortilin negatively regulates TGF-beta (zeige TGFB1 Proteine) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
SORT1 single nucleotide polymorphism and it's association with LDL cholesterol level and risk of coronary heart disease in Pakistani population
Four SNPs within the APOE (zeige APOE Proteine) cluster (rs7412, rs4420638), ABCC2 (zeige ABCC2 Proteine) (rs2002042) and CELSR/SORT1/PSRC1 (zeige PSRC1 Proteine) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
In older men, higher serum sortilin levels associated with higher major adverse cerebrovascular/cardiovascular disease risk and severe abdominal aortic calcification.
sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin (zeige NTS Proteine) binding site, and is a competitor of neurotensin (zeige NTS Proteine)
Focal adhesion kinase-sortilin interactions have an important role in colorectal cancer cells dissociation. (Review)
TDP-43 (zeige TARDBP Proteine) functions within a network of hnRNP (zeige HNRNPC Proteine) proteins to inhibit the production of a truncated human SORT1 receptor.
no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2 (zeige CELSR2 Proteine)-PSRC1 (zeige PSRC1 Proteine)-SORT1 and the risk of coronary artery disease or ischemic stroke
Inverse association between hepatic SORT1 gene expression and hepatic HBsAg expression indicates the possible role of sortilin in HBsAg particle formation.
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Sortilin has been found to inhibit the conversion of proBDNF into mature BDNF (zeige BDNF Proteine) by plasmin (zeige PLG Proteine) and to protect neurons from the apoptotic properties of proBDNF.
By contrast, treatment with dexamethasone, which also induced insulin (zeige INS Proteine) resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side
Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations.
sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase (zeige SMPD1 Proteine) activity and serum IL-6 (zeige IL6 Proteine).
This study demonstrated that Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.
TDP-43 (zeige TARDBP Proteine) functions within a network of hnRNP (zeige HNRNPH2 Proteine) proteins to inhibit the production of a truncated human SORT1 receptor.
Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas and salivary gland.
Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase (zeige SMPD1 Proteine) activity.
Overexpression of SORT1 was shown to reduce Very-Low-Density Lipoproteins , Triglyceride and Apolipoprotein B (zeige APOB Proteine) secretion in mice.
Prosaposin (zeige PSAP Proteine) facilitates sortilin-independent lysosomal trafficking of progranulin (zeige GRN Proteine).
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
, 100 kDa NT receptor
, glycoprotein 95
, neurotensin receptor 3
, glycoprotein 110