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Human rala Protein expressed in Escherichia coli (E. coli) - ABIN667292
Balasubramanian, Meier, Scott, Norambuena, White, Schwartz: RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. in Current biology : CB 2010
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striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (zeige Ralb Proteine).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (zeige GRIN1 Proteine)-long-term depression.
findings show either RALA or RALB (zeige Ralb Proteine) is sufficient for tumor growth; either RALA or RALB (zeige Ralb Proteine) is sufficient for cell proliferation; RALA and RALB (zeige Ralb Proteine) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (zeige PPP1R3A Proteine), RGC2) that mediates the activation of RalA downstream of the PI 3 (zeige PI3 Proteine)-kinase/Akt (zeige AKT1 Proteine) pathway
A novel regulatory pathway involves RalA and phospholipase D in the production of phosphatidic acid during Fc gamma receptor (zeige FCGR1A Proteine)-mediated phagocytosis and phagosome formation.
RalA but not RalB (zeige Ralb Proteine) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (zeige RALGDS Proteine) in response to a rise in intracellular Ca2 (zeige CA2 Proteine)+ and cAMP controls hormone release from pancreatic beta-cells
RalA is activated by H-Ras, which along with ARF6, leads to phospholipase D activation
results suggest that the small GTPase (zeige RACGAP1 Proteine) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (zeige CAV1 Proteine) and FilA but by stimulating PLD2 (zeige PLD2 Proteine)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (zeige AK3 Proteine)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 (zeige RCC2 Proteine) exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (zeige RACGAP1 Proteine) RalA. RCC2 (zeige RCC2 Proteine) and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (zeige HRAS Proteine) and RalB (zeige Ralb Proteine) and possibly RalA proteins is critical for maintaining low levels of p53 (zeige TP53 Proteine), and down-regulation of these GTPases reactivates p53 (zeige TP53 Proteine) by significantly enhancing its stability, contributing to suppression of malignant transformation
These results indicate that MLN8237 treatment may be effective for a subset of patients with PDAC independent of RalA S194 phosphorylation
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 (zeige SOX9 Proteine) and ACAN (zeige ACAN Proteine).
Data show that small GTPase (zeige RACGAP1 Proteine) RALA regulates formation of a JIP1 (zeige MAPK8IP1 Proteine) (C-Jun (zeige JUN Proteine)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (zeige MAPK8 Proteine) signaling toward FOXO4 (zeige FOXO4 Proteine) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (zeige ROS1 Proteine)).
RalA and RalB (zeige Ralb Proteine) exhibit both distinct and redundant roles in tumorigenesis (Review).
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A