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PCSK5 Proteine (PCSK5)

Bezeichnung:
Proprotein Convertase Subtilisin/kexin Type 5 Proteine (PCSK5)
Auf www.antikoerper-online.de finden Sie aktuell 12 Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PCSK5 Antikörper (43) und PCSK5 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 64 PCSK5 Produkte verfügbar.
Synonyme:
b2b585Clo, b2b1549Clo, fur2, MGC98915, Pc5, PC5/6A, PC5A, pc6, PC6A, PCSK5, SPC6, spc6a, subtilase
alle Proteine anzeigen Gen GeneID UniProt
PCSK5 18552 Q04592
Ratte PCSK5 PCSK5 116548 P41413
PCSK5 5125 Q92824

Weitere Synonyme anzeigen

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Am meisten referenzierte PCSK5 Proteine

  1. Human PCSK5 Protein expressed in Wheat germ - ABIN1314358 : Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015 (PubMed)

Weitere Proteine zu PCSK5 Interaktionspartnern

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5) Interaktionspartner

  1. loss of the convertase furin (zeige FURIN Proteine) or PC5/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Proteine) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C (zeige PROC Proteine) in hepatocytes is critical for its thrombin (zeige F2 Proteine) activation.

  2. overexpression of PCs, furin (zeige FURIN Proteine) and PC5, but not PC7 (zeige PCSK7 Proteine), which are all expressed in SMC (zeige DYM Proteine), increase PKGI (zeige PRKG1 Proteine) cleavage in a dose-dependent manner

  3. Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.

  4. PCSK5 and GDF11 (zeige GDF11 Proteine) expression during hindgut morphogenesis could be key factors for normal anorectal development, which can be disturbed by the administration of an overdose of all-trans retinoic acid, leading to anorectal malformations.

  5. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

  6. These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.

  7. Data suggest that intestinal PC5/6 is protective towards tumorigenesis, especially in mouse duodenum, and possibly in human colon.

  8. The proprotein convertase PC5A and a metalloprotease (zeige ADAMTS7 Proteine) are involved in the proteolytic processing of the neural adhesion molecule (zeige CNTN6 Proteine) L1.

  9. large cysteine-rich region acts as an important part of functional domain of PC6

  10. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation

Human Proprotein Convertase Subtilisin/kexin Type 5 (PCSK5) Interaktionspartner

  1. loss of the convertase furin (zeige FURIN Proteine) or PC5/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC Proteine) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 Proteine) activation.

  2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene.

  3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation

  4. Proprotein convertase 5/6 cleaves PDGFA (zeige PDGFA Proteine) in the human endometrium in preparation for embryo implantation.

  5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 (zeige BMP2 Proteine) signaling pathway.

  6. overexpression of PCs, furin (zeige FURIN Proteine) and PC5, but not PC7 (zeige PCSK7 Proteine), which are all expressed in SMC (zeige DYM Proteine), increase PKGI (zeige PRKG1 Proteine) cleavage in a dose-dependent manner

  7. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas

  8. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization.

  9. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

  10. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility

PCSK5 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PCSK5

  • proprotein convertase subtilisin/kexin type 5 (PCSK5)
  • proprotein convertase subtilisin/kexin type 5 (pcsk5)
  • proprotein convertase subtilisin/kexin type 5 (Pcsk5)
  • b2b585Clo Protein
  • b2b1549Clo Protein
  • fur2 Protein
  • MGC98915 Protein
  • Pc5 Protein
  • PC5/6A Protein
  • PC5A Protein
  • pc6 Protein
  • PC6A Protein
  • PCSK5 Protein
  • SPC6 Protein
  • spc6a Protein
  • subtilase Protein

Bezeichner auf Proteinebene für PCSK5

proprotein convertase subtilisin/kexin type 5 , proprotein convertase PC6 , proprotein convertase 6A , proprotein convertase 6B , proprotein convertase 6C , proprotein convertase 6D , proprotein convertase 6E , proprotein convertase 6F , subtilisin-like protease SPC6A , proprotein convertase 5 , proprotein convertase 6 , proprotein convertase PC5 , subtilisin-like proprotein convertase 6 , subtilisin/kexin-like protease PC5 , hPC6 , prohormone convertase 5 , protease PC6

GENE ID SPEZIES
395456 Gallus gallus
446297 Xenopus laevis
464533 Pan troglodytes
484160 Canis lupus familiaris
528098 Bos taurus
779961 Xenopus (Silurana) tropicalis
100589851 Nomascus leucogenys
18552 Mus musculus
116548 Rattus norvegicus
5125 Homo sapiens
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