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Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4, PON3 (zeige PON3 Proteine), STAT5a (zeige STAT5A Proteine), and VAX2 (zeige VAX2 Proteine) gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation (zeige HELLS Proteine) analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor
These data demonstrate, that in addition to microtubule-independent Tiam1 (zeige TIAM1 Proteine) activation, HGF (zeige HGF Proteine) engages additional microtubule- and APC (zeige APC Proteine)-dependent pathway of Asef activation.
these results demonstrate potent anti-inflammatory effects by HGF (zeige HGF Proteine) and delineate a key role of Asef in the mediation of the HGF (zeige HGF Proteine) barrier protective and anti-inflammatory effects.
Expression of Asef was associated with lower estimated glomerular filtration rate in kidney disease.
Expression of ARHGEF4 (Rho guanine nucleotide exchange factor 4) is restricted to the brain and may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function
structures thus elucidate the molecular mechanism of Asef recognition by APC (zeige APC Proteine)
Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size
Positive role of Tyr94 phosphorylation in EGF-induced Asef activation following the activation of Rac1.
Asef and APC (zeige APC Proteine) function downstream of HGF (zeige HGF Proteine) and PI3-kinase (zeige PIK3CA Proteine), and play critical roles in growth factor-mediated regulation of cell morphology and migration
Asef has a role in HGF (zeige HGF Proteine)-mediated protection against endothelial hyperpermeability and lung injury.
Asef and Asef2 (zeige SPATA13 Proteine) are required for adenoma formation in Apc (zeige APC Proteine)(Min/+)mice.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
Rho guanine nucleotide exchange factor (GEF) 4
, Rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4-like
, APC-stimulated guanine nucleotide exchange factor 1
, APC-stimulated guanine nucleotide exchange factor