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striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB (zeige Ralb ELISA Kits).
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Our results provide the first in vivo characterization of RalA function in the mammalian brain and highlight a novel molecular mechanism for cell polarization.
The constitutively increased RalA activity occludes further increases in RalA activity during induction of long-term depression, causing impaired NMDAR (zeige GRIN1 ELISA Kits)-long-term depression.
findings show either RALA or RALB (zeige Ralb ELISA Kits) is sufficient for tumor growth; either RALA or RALB (zeige Ralb ELISA Kits) is sufficient for cell proliferation; RALA and RALB (zeige Ralb ELISA Kits) act in a redundant fashion
study reports the identification and characterization of a Ral GAP complex (RG1 (zeige PPP1R3A ELISA Kits), RGC2 (zeige RALGAPA2 ELISA Kits)) that mediates the activation of RalA downstream of the PI 3 (zeige PI3 ELISA Kits)-kinase/Akt (zeige AKT1 ELISA Kits) pathway
A novel regulatory pathway involves RalA and phospholipase D (zeige PLD ELISA Kits) in the production of phosphatidic acid during Fc gamma receptor (zeige FCGR1A ELISA Kits)-mediated phagocytosis and phagosome formation.
RalA but not RalB (zeige Ralb ELISA Kits) mediates integrin-dependent membrane raft exocytosis through the exocyst complex. Constitutively active RalA restores membrane raft targeting to promote anchorage-independent growth signaling.
RalA activation elicited by the exchange factor RalGDS (zeige RALGDS ELISA Kits) in response to a rise in intracellular Ca2 (zeige CA2 ELISA Kits)+ and cAMP controls hormone release from pancreatic beta-cells
RalA is activated by H-Ras (zeige HRAS ELISA Kits), which along with ARF6 (zeige ARF6 ELISA Kits), leads to phospholipase D (zeige PLD ELISA Kits) activation
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R and D3R, through GRK2 and beta-arrestins, respectively. Active RalA was found to interact with GRK2 to sequester it from D2R. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
results suggest that the small GTPase (zeige RACGAP1 ELISA Kits) RalA plays an important role in promoting invagination and trafficking of caveolae, not by potentiating the association between Cav-1 (zeige CAV1 ELISA Kits) and FilA but by stimulating PLD2 (zeige PLD2 ELISA Kits)-mediated generation of phosphatidic acid.
agonist-induced Gbetagamma-mediated conversion of RalA from the GTP (zeige AK3 ELISA Kits)-bound form to the GDP-bound form could be a mechanism to facilitate agonist-induced internalization of GPCRs.
RCC2 exhibits guanine exchange factor activity, in vitro and in cells, for the small GTPase (zeige RACGAP1 ELISA Kits) RalA. RCC2 and RalA apparently work together to contribute to the regulation of kinetochore-microtubule interactions in early mitosis.
expression of K-Ras (zeige HRAS ELISA Kits) and RalB (zeige Ralb ELISA Kits) and possibly RalA proteins is critical for maintaining low levels of p53 (zeige TP53 ELISA Kits), and down-regulation of these GTPases reactivates p53 (zeige TP53 ELISA Kits) by significantly enhancing its stability, contributing to suppression of malignant transformation
These results indicate that MLN8237 treatment may be effective for a subset of patients with PDAC independent of RalA S194 phosphorylation
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 (zeige SOX9 ELISA Kits) and ACAN (zeige ACAN ELISA Kits).
Data show that small GTPase (zeige RACGAP1 ELISA Kits) RALA regulates formation of a JIP1 (zeige MAPK8IP1 ELISA Kits) (C-Jun (zeige JUN ELISA Kits)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (zeige MAPK8 ELISA Kits) signaling toward FOXO4 (zeige FOXO4 ELISA Kits) (forkhead box O transcription factor) in response to reactive oxygen species (ROS (zeige ROS1 ELISA Kits)).
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.
RAS-like, family 1
, ral-A protein
, ras-related protein Ral-A
, -ral simian leukemia viral oncogene homolog A (ras related)
, RAS-like protein A
, Ras family small GTP binding protein RALA
, ras related v-ral simian leukemia viral oncogene homolog A