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Human Polyclonal MEF2A Primary Antibody für IHC - ABIN966555
Kato, Zhao, Morikawa, Sugiyama, Chakravortty, Koide, Yoshida, Tapping, Yang, Yokochi, Lee: Big mitogen-activated kinase regulates multiple members of the MEF2 protein family. in The Journal of biological chemistry 2000
Show all 2 Pubmed References
Human Polyclonal MEF2A Primary Antibody für IHC - ABIN966556
Zhao, New, Kravchenko, Kato, Gram, di Padova, Olson, Ulevitch, Han: Regulation of the MEF2 family of transcription factors by p38. in Molecular and cellular biology 1999
Show all 2 Pubmed References
Human Monoclonal MEF2A Primary Antibody für ELISA, WB - ABIN1724919
Guella, Rimoldi, Asselta, Ardissino, Francolini, Martinelli, Girelli, Peyvandi, Tubaro, Merlini, Mannucci, Duga: Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease. in Circulation. Cardiovascular genetics 2009
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Human Polyclonal MEF2A Primary Antibody für IF, IHC - ABIN361950
Satoh, Ohnishi, Sato, Takeyama, Iemura, Natsume, Shibuya: Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. in Molecular and cellular biology 2007
Human Polyclonal MEF2A Primary Antibody für IHC, IHC (p) - ABIN4333438
Zehorai, Seger: Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases. in Molecular and cellular biology 2013
Using a dominant-negative SmMef2 mutant, authors provide evidence that SmMef2 may regulate genes in the WNT (zeige WNT2 Antikörper) pathway.
The authors identify and characterize Mef2 (zeige MYEF2 Antikörper) from the schistosome worm Schistosoma mansoni (SmMef2).
in leiomyosarcomas (LMS), this two-faced trait of MEF2 is relevant for tumor aggressiveness. Class IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2, HDAC4 (zeige HDAC4 Antikörper) and HDAC9 (zeige HDAC9 Antikörper) inversely correlate with overall survival. The knock out of HDAC9 (zeige HDAC9 Antikörper) suppresses the transformed phenotype of LMS cells, by restoring the transcriptional proficiency of some MEF2-target loci
The discovery of a novel MEF2A mutation in a Chinese family with premature CAD (zeige CAD Antikörper)/MI suggests that MEF2A may have a significant role in the pathogenesis of premature CAD (zeige CAD Antikörper)/MI.
The findings of this study are consistent with MEF2A deregulation conferring risk of formal thought disorder.
Variants in the 3'-UTR of MEF2A are associated with coronary artery disease in a Chinese Han population.
p38 MAPK (zeige MAPK14 Antikörper) is a key regulator of canonical Wnt (zeige WNT2 Antikörper) signaling by promoting a phospho-dependent interaction between MEF2 and beta-catenin (zeige CTNNB1 Antikörper) to enhance cooperative transcriptional activity and cell proliferation.
Mechanistically, MEF-2 (zeige MYEF2 Antikörper) was recruited to the viral promoter (LTR, long terminal repeat) in the context of chromatin, and constituted Tax (zeige CNTN2 Antikörper)/CREB (zeige CREB1 Antikörper) transcriptional complex via direct binding to the HTLV-1 LTR.
Our results revealed a link and interaction between MEF2A and miR (zeige MLXIP Antikörper)-143 and suggested a potential mechanism for MEF2A to regulate H(2)O(2) -induced VSMC senescence.
six or seven amino acid deletions and synonymous mutations (147143G-->A)in exon 11 of the MEF2A gene may be correlated with susceptibility to coronary artery disease in the Chinese population
MEF2A is targeted to lysosomes for chaperone-mediated autophagy degradation; oxidative stress-induced (zeige SQSTM1 Antikörper) lysosome destabilization leads to the disruption of MEF2A degradation as well as the dysregulation of its function
MEF2 transcription factors promotes epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma through TGF-beta1 (zeige TGFB1 Antikörper) autoregulation circuitry.
Deficiency of AKT2 (zeige AKT2 Antikörper) in myocardium results in diminished MEF2A abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG (zeige ENDOG Antikörper), which is also regulated by AKT2 (zeige AKT2 Antikörper), is a suppressor of MEF2A in myocardium.
these data indicate that MEF2 (zeige MEF2C Antikörper) and AP-1 (zeige JUN Antikörper) confer antagonistic regulation of Hspb7 (zeige HSPB7 Antikörper) gene expression in skeletal muscle, with implications for autophagy and muscle atrophy.
Nuclear HDAC4 (zeige HDAC5 Antikörper) binds to chromatin as well as to MEF2A transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 (zeige CDKL5 Antikörper) knockout (Cdkl5 (zeige CDKL5 Antikörper) -/Y) mouse model, we found that hypophosphorylated HDAC4 (zeige HDAC5 Antikörper) translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation.
Knockdown of MEF2A significantly reduced hyperglycemia-induced cardiac fibroblast proliferation and migration, myofibroblast differentiation, matrix metalloproteinase activities, and collagen production.
Lentivirus-mediated MEF 2A shRNA accelerates inflammation and atherosclerosis in APOE (zeige APOE Antikörper) knockout mice, but has no effect on lipoprotein levels in plasma.
microRNAs encoded by the Gtl2-Dio3 (zeige DIO3 Antikörper) noncoding RNA locus function downstream of the MEF2A
Our results indicated that exercise-induced CPT1b (zeige CPT1B Antikörper) expression was at least in part mediated by HDAC5 (zeige HDAC5 Antikörper)/MEF2A interaction.
Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B (zeige MEF2B Antikörper), -C, and -D were found to be dispensable for this process.
A role for endogenous MEF2 (zeige MEF2C Antikörper) factors exclusively in hormone/Fsk/cAMP-induced Nr4a1 (zeige NR4A1 Antikörper) gene expression in mouse MA-10 Leydig cells.
These results show that NLK specifically regulates the MEF2A activity required for anterior formation in Xenopus development.
polymorphisms in the bovine MEF2A gene and their effect on the MEF2A mRNA expression level in the longissimus dorsi muscle
Mef2 (zeige MYEF2 Antikörper) controls skeletal muscle formation after terminal differentiation.
Results suggest that myocyte-specific enhancer factor 2A is essential for cardiac contractility
Results suggest that myocyte enhancer factor 2A is essential for zebrafish posterior somite development.
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
myocyte-specific enhancer factor 2A
, myocyte-specific enhancer factor 2a
, myocyte enhancer factor 2A
, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)
, myocyte-specific enhancer factor 2A-like
, myocyte-specific enhancer factor 2A homolog
, serum response factor-like protein 1
, serum response factor-like protein 2
, myocyte enhancer factor 2a