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these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK (zeige PRKAA1 ELISA Kits)/Ulk1 (zeige ULK1 ELISA Kits)/Atg13 (zeige ATG13 ELISA Kits) autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer.
MAGED1 binds and positively regulates the transcriptional activity of family members SIM1 (zeige SIM1 ELISA Kits), SIM2 (zeige SIM2 ELISA Kits), NPAS4 (zeige NPAS4 ELISA Kits) and ARNT2 (zeige ARNT2 ELISA Kits), but does not interact with AhR (zeige AHR ELISA Kits), HIF1alpha (zeige HIF1A ELISA Kits) and ARNT (zeige ARNT ELISA Kits). This interaction is mediated by PAS (zeige PASK ELISA Kits) repeat regions which also form the interface for bHLH PAS (zeige PASK ELISA Kits) dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS (zeige PASK ELISA Kits) dimers.
our surprise, NRAGE induces nuclear localization of beta-catenin (zeige CTNNB1 ELISA Kits) and increases its DNA binding ability. Further studies reveal that NRAGE leads to the modification of beta-catenin/Arm with O-linked beta-N-acetylglucosamine (O-GlcNAc (zeige OGT ELISA Kits)), and failure of the association between beta-catenin/Arm and pygopus(pygo) protein, which is required for transcriptional activation of Wnt (zeige WNT2 ELISA Kits) target genes. Therefore, our findings suggest a ...
Loss of GSPT2 (zeige GSPT2 ELISA Kits) and/or MAGED1 function may contribute to the intellectual disability.
The ectopic subcellular localization of NRAGE mediated nuclear translocation of beta-catenin (zeige CTNNB1 ELISA Kits).
High NRAGE expression is associated with esophageal carcinomas.
MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages.
Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factor in colorectal carcinoma
NRAGE may participate in the formation of radioresistance of TE13R120 cells by changing its subcellular localization, but its relationship with cell apoptosis has not been confirmed.
we establish the roles for Dlxin-1, one as an anti-tumorigenic and anti-invasive protein in high-grade gliomas and the other as an inducer of differentiation of glioma stem cells.
Both transient and stable expression of Necdin (zeige NDN ELISA Kits) induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation.
MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model
Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB (zeige CREB ELISA Kits)).
NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB (zeige NFKB1 ELISA Kits) signalling pathway.
Show Ror2 (zeige ROR2 ELISA Kits) expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 (zeige ROR2 ELISA Kits) is a potential factor in the tumorigenesis and metastasis in a Src (zeige SRC ELISA Kits)-dependent manner that is negatively regulated by NRAGE.
We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes
Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD (zeige BEST1 ELISA Kits))
the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT (zeige SLC6A4 ELISA Kits) ubiquitylation.
XIAP (zeige XIAP ELISA Kits)-TAB1 (zeige TAB1 ELISA Kits)-TAK1 (zeige NR2C2 ELISA Kits) complex is dependent on NRAGE for IKK-alpha (zeige CHUK ELISA Kits)/beta phosphorylation and NF-kappaB (zeige NFKB1 ELISA Kits) activation.
MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1 (zeige ARNTL ELISA Kits), Rev-erbalpha (zeige NR1D1 ELISA Kits) and E4bp4 (zeige NFIL3 ELISA Kits) expression through the Rev-Erbalpha (zeige NR1D1 ELISA Kits)/ROR responsive elements (RORE).
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
melanoma antigen family D, 1
, melanoma-associated antigen D1
, melanoma-associated antigen D1-like
, MAGE tumor antigen CCF
, MAGE-D1 antigen
, neurotrophin receptor-interacting MAGE homolog
, sertoli cell necdin-related gene protein 1