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analysis of the Kindlin-2-RhoGDIalpha-Rac1 signaling axis that is critical for regulation of podocyte structure and function in vivo
Data suggest that the interaction between PCBP2 (zeige PCBP2 ELISA Kits) and the 3'UTR (zeige UTS2R ELISA Kits) of the ARHGDIA mRNA may induce a local change in RNA structure that favors subsequent binding of miR (zeige MLXIP ELISA Kits)-151-5p and miR-16 (zeige GDE1 ELISA Kits), thus leading to the suppression of ARHGDIA expression.
our results suggest that RhoGDIalpha regulate TRF1 (zeige TERF1 ELISA Kits) and telomere length and may be novel prognostic biomarkers in colorectal cancer
Together, our results suggest a role for Ly-GDI (zeige ARHGDIB ELISA Kits) in the localized regulation of Rho GTPases in platelets and hypothesize a link between the PKC and Rho GTPase (zeige RACGAP1 ELISA Kits) signaling systems in platelet function.
MiR (zeige MLXIP ELISA Kits)-25 is activated by the WNT (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling pathway, and exerts its pro-metastatic function by directly inhibiting the Rho GDP dissociation inhibitor alpha (RhoGDI1). Downregulation of RhoGDI1 enhances expression of Snail (zeige SNAI1 ELISA Kits), thereby promoting EMT (zeige ITK ELISA Kits).
RIP2 (zeige ARHGEF28 ELISA Kits) and RhoGDI bind to p75(NTR (zeige NGFR ELISA Kits)) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 (zeige ARHGEF28 ELISA Kits) recruitment displaces RhoGDI upon ligand binding.
Downregulation of RhoGDI could be a critical mechanism of breast tumor development, which may involve the hyperactivation of Rho GTPases and upregulation of COX-2 (zeige COX2 ELISA Kits) activity.
RHOGDI alpha acetylation interferes with Rho signaling, resulting in alteration of cellular filamentous actin.
the present study has identified loss of ARHGDIA contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis
new mechanistic insights into the understanding of essential role of SUMOylation at Lys (zeige LYZ ELISA Kits)-138 in RhoGDIalpha's biological function.
Increased expression of bovine Rho GDIalpha (zeige GDI1 ELISA Kits) led to electrophysiological alterations that resulted in atrial arrhythmias and AV conduction abnormalities in transgenic mice, whereas ventricular contractile function was largely preserved.
that inhibition of Ca2 (zeige CA2 ELISA Kits)+ channel activity by overexpression of Rho GDI-alpha is mediated by inhibition of RhoA (zeige RHOA ELISA Kits) in cardiac myocytes
Rho GDP association inhibitor (GDI) alpha- mediated disruption of Rho GTPase (zeige RACGAP1 ELISA Kits) activity impairs lens fiber cell migration, elongation and survival.
GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes
Integrin beta 8 and PTP-PEST (zeige PTPN12 ELISA Kits) form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 (zeige CDC42 ELISA Kits) signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1.
RhoGDalpha controls ENaC expression and activity via Rac1.
the association of RhoGDIalpha with TROY (zeige TNFRSF19 ELISA Kits) contributed to TROY (zeige TNFRSF19 ELISA Kits)-dependent RhoA (zeige RHOA ELISA Kits) activation and neurite outgrowth inhibition after Nogo (zeige RTN4 ELISA Kits)-66 stimulation.
Data found that CCK (zeige CCK ELISA Kits)-induced PKCalpha (zeige PKCa ELISA Kits) phosphorylation on RhoGDI1 at Ser96 releases RhoA (zeige RHOA ELISA Kits) and Rac1 from RhoGDI1 to facilitate Rho GTPases signaling.
we demonstrated the regulation of targeting/accumulation of the RhoGDIalpha-Rac1 complex to phagosomes
how the beta cell utilizes RhoGDI for differential Cdc42 and Rac1 cycling
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis (zeige XIRP1 ELISA Kits) and inhibits cardiomyocyte proliferation.
analysis of inhibitory and shuttling functions of rhoGDI-3 (zeige ARHGDIG ELISA Kits) and rhoGDI-1
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993
rho GDI 1
, rho GDP-dissociation inhibitor 1
, rho-GDI alpha
, Rho GDP dissociation inhibitor (GDI) alpha
, Rho GDI alpha