anti-ARHGEF2 (ARHGEF2) Antikörper

Bezeichnung:
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 Antikörper (ARHGEF2)
Auf www.antikoerper-online.de finden Sie aktuell 71 rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Antikörper von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ARHGEF2 Proteine (6) und ARHGEF2 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 88 ARHGEF2 Produkte verfügbar.
Synonyme:
AA408978, GEF, GEF-H1, GEF-H1/LFC, GEFH1, Lbcl1, Lfc, LFP40, MGC75855, MGC82333, MGC86214, mKIAA0651, P40

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anti-Mouse (Murine) ARHGEF2 Antikörper:

anti-Human ARHGEF2 Antikörper:

anti-Rat (Rattus) ARHGEF2 Antikörper:

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Am meisten referenzierte anti-ARHGEF2 Antikörper

  1. Dog (Canine) Monoclonal ARHGEF2 Primary Antibody für IHC (fro), IF - ABIN1105439 : Aijaz, DAtri, Citi, Balda, Matter: Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. in Developmental cell 2005 (PubMed)
    Zeige alle 4 Referenzen für 1105439

  2. Mouse (Murine) Polyclonal ARHGEF2 Primary Antibody für IF, IP - ABIN264980 : Glaven, Whitehead, Bagrodia, Kay, Cerione: The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells. in The Journal of biological chemistry 1999 (PubMed)

Weitere Antikörper gegen ARHGEF2 Interaktionspartner

Xenopus laevis rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Interaktionspartner

Mouse (Murine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Interaktionspartner

  1. human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.

  2. These results identify GEF-H1 as a component of the shear stress response machinery in neutrophils required for a fully competent immune response to bacterial infection.

  3. Study describes a new mode of GEF-H1 activation in response to G-protein-coupled receptor (GPCR (zeige TAS1R3 Antikörper)) ligands that is independent of microtubule depolymerization.

  4. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I (zeige DDX58 Antikörper)-like receptors.

  5. Pak2 (zeige PAK2 Antikörper), but not Pak1 (zeige PAK1 Antikörper), negatively regulates RhoA (zeige RHOA Antikörper) via phosphorylation of the guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) GEF-H1 at an inhibitory site, leading to increased GEF-H1 microtubule binding and loss of RhoA (zeige RHOA Antikörper) stimulation

  6. It was shown that the guanine exchange factors GEF-H1 and ECT2 (zeige ECT2 Antikörper) must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 (zeige ECT2 Antikörper) downregulation.

  7. CAPN6 (zeige CAPN6 Antikörper) acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.

  8. LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras

  9. p114-RhoGEF (zeige ARHGEF18 Antikörper) and Lfc are critically involved in Wnt-3a (zeige WNT3A Antikörper)- and Dvl (zeige DVL1 Antikörper)-induced RhoA (zeige RHOA Antikörper) activation and neurite retraction in N1E-115 cells.

  10. Depletion of GEF-H1 in the murine two-hit model of VILI attenuated vascular leak induced by lung ventilation at high tidal volume and thrombin (zeige F2 Antikörper)-derived peptide TRAP6.

Human rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Interaktionspartner

  1. depletion induces phosphorylation of the microtubule-associated GEF-H1 on Ser886, and thereby promotes RhoA activity and actin stress fiber assembly.

  2. human brain malformation is recapitulated in Arhgef2 mutant mice and identify an aberrant migration of distinct components of the precerebellar system as a pathomechanism underlying the midbrain-hindbrain phenotype. Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder.

  3. Overexpression of miR (zeige MLXIP Antikörper)-194 downregulates the GEF-H1/RhoA (zeige RHOA Antikörper) pathway, inhibits melanoma cancer cell proliferation and metastasis. Furthermore, miR (zeige MLXIP Antikörper)-194 expression is negatively associated with tumor-node-metastasis (TNM (zeige ODZ1 Antikörper)) stages

  4. data suggest that the induction of SGK1 (zeige SGK1 Antikörper) through treatment with dexamethasone alters MT dynamics to increase Sec5 (zeige EXOC2 Antikörper)-GEF-H1 interactions, which promote GEF-H1 targeting to adhesion sites.

  5. this study reports the crystal structure of human GEF-H1 PH domain to 2.45 A resolution.

  6. By stimulating cofilin (zeige CFL1 Antikörper)/PP2A (zeige PPP2R4 Antikörper)-mediated dephosphorylation of the guanine nucleotide exchange factor (zeige RASGRF1 Antikörper) GEF-H1.

  7. regulation of c-Src trafficking requires both microtubules and actin polymerization, and GEF-H1 coordinates c-Src trafficking, acting as a molecular switch between these two mechanisms

  8. Results supported that miR (zeige MLXIP Antikörper)-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 (zeige DOCK3 Antikörper) in NSCLC A549 and H1299 cell lines.

  9. TGF-beta (zeige TGFB1 Antikörper) regulates LARG (zeige ARHGEF12 Antikörper) and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.

  10. Our findings underscore a potent oncogenic role for GEF-H1 in promoting the metastatic potentials of hepatocellular carcinoma, possibly through activation of RhoA (zeige RHOA Antikörper) signalling.

Pig (Porcine) rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) Interaktionspartner

  1. Data indicate that TNF-alpha (zeige TNF Antikörper) stimulates Rac (zeige AKT1 Antikörper), ADAM17/TACE (zeige ADAM17 Antikörper), and RhoA (zeige RHOA Antikörper) through the guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) (GEF)-H1.

  2. Data indicate that GEF-H1 is a target and functional effector of TGF-beta (zeige TGFB1 Antikörper) by orchestrating Rho signaling to regulate gene expression and cell migration.

  3. ERK/GEF-H1/Rho/ROK/pMLC pathway could be a central mechanism whereby electrogenic transmembrane transport processes control myosin phosphorylation and regulate paracellular transport in the tubular epithelium.

  4. the ERK (zeige MAPK1 Antikörper)/GEF-H1/Rho/Rho kinase (zeige ROCK1 Antikörper)/phospho-MLC pathway is the mechanism mediating TNF-alpha (zeige TNF Antikörper)-induced elevation of tubular epithelial permeability, which in turn might contribute to kidney injury

ARHGEF2 Antigen-Profil

Beschreibung des Gens

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with ARHGEF2

  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2) Antikörper
  • Rho/Rac guanine nucleotide exchange factor (GEF) 2 (arhgef2) Antikörper
  • Rho/Rac guanine nucleotide exchange factor 2 (LOC100346634) Antikörper
  • rho/rac guanine nucleotide exchange factor (GEF) 2 (Arhgef2) Antikörper
  • AA408978 Antikörper
  • GEF Antikörper
  • GEF-H1 Antikörper
  • GEF-H1/LFC Antikörper
  • GEFH1 Antikörper
  • Lbcl1 Antikörper
  • Lfc Antikörper
  • LFP40 Antikörper
  • MGC75855 Antikörper
  • MGC82333 Antikörper
  • MGC86214 Antikörper
  • mKIAA0651 Antikörper
  • P40 Antikörper

Bezeichner auf Proteinebene für ARHGEF2

Rho/Rac guanine nucleotide exchange factor (GEF) 2 , guanine nucleotide exchange factor LFC , Rho/Rac guanine nucleotide exchange factor 2 , rho guanine nucleotide exchange factor 2-like , LBC'S first cousin , guanine nucleotide exchange factor H1 , lymphoid blast crisis-like 1 , oncogene LFC , rho guanine nucleotide exchange factor 2 , rhobin , microtubule-regulated Rho-GEF , proliferating cell nucleolar antigen p40 , GEF-H1 , Guanine nucleotide exchange factor H1 , rho/rac guanine nucleotide exchange factor 2 , tight junction-associated guanine nucleotide exchange factor

GENE ID SPEZIES
100057582 Equus caballus
398353 Xenopus laevis
407848 Xenopus (Silurana) tropicalis
457378 Pan troglodytes
719369 Macaca mulatta
100346634 Oryctolagus cuniculus
100434709 Pongo abelii
100601565 Nomascus leucogenys
16800 Mus musculus
9181 Homo sapiens
310635 Rattus norvegicus
403498 Canis lupus familiaris
100145887 Sus scrofa
505940 Bos taurus
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