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anti-Human UCP2 Antikörper:
anti-Mouse (Murine) UCP2 Antikörper:
anti-Rat (Rattus) UCP2 Antikörper:
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Human Polyclonal UCP2 Primary Antibody für IF (p), IHC (p) - ABIN675428
Chuang, Lin, Huang, Chang, Liou, Chen, Chang, Chan et al.: Peroxisome proliferator-activated receptors ?/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status ... in Journal of neuroinflammation 2012
Show all 2 Pubmed References
except for reduced lipid peroxidation, we did not observe any significant reactive oxygen species reduction associated with increased Ucp2 activation in cold-exposed group.
UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.
The data indicate that in the context of hepatocellular carcinoma, miR (zeige MLXIP Antikörper)-214 acts as a putative tumour suppressor by targeting UCP2 and defines a novel mechanism of regulation of UCP2.
UCP2 inhibition triggered cellular apoptosis and autophagy.
The GG genotype of the UCP1 (zeige UCP1 Antikörper)-3826 A/G polymorphism appears to contribute to the onset of childhood obesity in Turkish children. The GG genotype of UCP1 (zeige UCP1 Antikörper), together with the del/del genotype of the UCP2 polymorphism, may increase the risk of obesity with synergistic effects. The ins (zeige INS Antikörper) allele of the UCP2 exon 8 del/ins (zeige INS Antikörper) polymorphism may contribute to low HDL (zeige HSD11B1 Antikörper) cholesterolemia.
Expression of UCP2 and PLIN1 (zeige PLIN1 Antikörper) genes influences the resting metabolic rate in obese individuals and could predict the weight loss after bariatric surgery.
The lack of association with ECG derived QTd and UCP2 DD may suggest that gene-related QRS (zeige QARS Antikörper) duration prolongation is independent of cardiac hypertrophy.
Cellular feedback regulation may occur between UCP2/UCP3 (zeige UCP3 Antikörper) and ACE (zeige ACE Antikörper). Cellular UCP (zeige UCP1 Antikörper) regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism.
Study reports that insulin (zeige INS Antikörper) resistance-related gene polymorphisms effects colorectal cancer (CRC (zeige CALR Antikörper)) risk. The results showed that the gene polymorphism of ADIPOQ rs2241766 was associated with CRC (zeige CALR Antikörper) risk. Furthermore, the interactions of ADIPOQ rs2241766, UCP2 rs659366, FABP2 (zeige FABP2 Antikörper) rs1799883 and red meat consumption may contribute to the risk of CRC (zeige CALR Antikörper).
the major components of metabolic syndrome in patients with non-alcoholic fatty liver disease (NAFLD (zeige TSC2 Antikörper)) and nutritional intakes according to different genotype of uncoupling protein-2 (UCP2) -866G/A gene polymorphism in these patients, are reported.
Data suggest that UCP2 is an important regulator of mitochondrial redox status and lipid signaling, and that hydrogen peroxide might mediate UCP2's tumor promoting activity in skin.
UCP2 has two glycine-rich motifs, motif 1: EGIRGLWKG (170-178) and a Walker A-like motif 2: EGPRAFYKG (264-272). These motifs seem to be important for the function of UCP2. UCP2/K177E- or UCP2/G174L-expressed cells did not induce enlarged cell shapes. UCP2/K177E and UCP2/G174L produced functional incompetence of the glycine-rich motif 1. Senescent-like cells significantly decreased the mitochondrial membrane potentials.
our findings reveal that UCP2 regulates inflammation responses in astrocytes and plays an important role in the pathogenesis of depression and that UCP2 may be a promising therapeutic target for depression.
These results suggest that Leishmania exploits A20 (zeige TNFAIP3 Antikörper) and UCP2 to impair inflammasome activation for disease propagation
UCP-2 prevents angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E (zeige APOE Antikörper)-knockout mice via antioxidant and antiapoptotic activities.
This study demonstrating a FABP4 (zeige FABP4 Antikörper)-UCP2 axis with the potential to modulate the microglial inflammatory response.
The miR (zeige MLXIP Antikörper)-133a-UCP2 pathway participates in inflammatory bowel disease (IBD) by altering downstream inflammation, oxidative stress and markers of energy metabolism, which provides novel clues and potential therapeutic targets for IBD.
PPARgamma (zeige PPARG Antikörper) inhibited PDGF (zeige PDGFA Antikörper)-BB-induced ROS (zeige ROS1 Antikörper) in VSMCs by upregulating UCP2 expression.
these data offer a novel pathway whereby FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2 expression.
Ucp2 affects glutathione metabolism by regulating hepatic efflux of glutathione. Nrf2 (zeige NFE2L2 Antikörper) deficiency may not aggravate oxidative stress in Ucp2-deficient mice.
Induction of autophagy by SCFAs required PPARgamma (zeige PPARG Antikörper) stimulation of Uncoupling Protein 2 (UCP2) expression that was associated with reduced intracellular ATP levels and activation of PRKAA1/AMPK (zeige PRKAA1 Antikörper) (protein kinase (zeige CDK7 Antikörper), AMP (zeige TMPRSS5 Antikörper)-activated, alpha 1 catalytic subunit). In addition, elimination of gut (zeige GUSB Antikörper) flora by chronic antibiotic treatment diminished basal hepatic autophagy in mice suggesting that gut (zeige GUSB Antikörper) microbiota can regulate hepatic auto...
Despite patent grafts, revascularized hibernating myocardium demonstrates a submaximal response to dobutamine infusion and increased mitochondrial UCP-2 expression.
Seven deletion polymorphisms were covered in introns of linkage genes of UCP2 and UCP3 (zeige UCP3 Antikörper), showing that UCPs have conservation and genetic reliability.
The in vivo data indicate that beta-adrenergic agonists may function in regulating UCP2 and UCP3 (zeige UCP3 Antikörper) expression in selected muscles.
UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 (zeige UCP1 Antikörper) or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro.
A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI (zeige RNF34 Antikörper)) in Angus steers selected to have high or low RFI (zeige RNF34 Antikörper) is presented.
These results suggest that UCP2 play an important role of lipid and energy metabolism in mammary epithelial cells.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.
mitochondrial uncoupling protein 2
, uncoupling protein 2 (mitochondrial, proton carrier)
, Mitochondrial uncoupling protein 2
, uncoupling protein 2
, UCP 2
, solute carrier family 25 member 8
, uncoupling protein 2, mitochondrial
, uncoupling protein homolog
, Uncoupling protein 2, mitochondrial