SYTL4 Proteine (SYTL4)

Bezeichnung:
Synaptotagmin-Like 4 Proteine (SYTL4)
Auf www.antikoerper-online.de finden Sie aktuell 4 Synaptotagmin-Like 4 (SYTL4) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SYTL4 Antikörper (30) und SYTL4 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 37 SYTL4 Produkte verfügbar.
Synonyme:
Gph, Slp4
alle Proteine anzeigen Gen GeneID UniProt
SYTL4 94121 Q96C24
SYTL4 27359 Q9R0Q1
SYTL4 140594 Q8VHQ7

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Weitere Proteine zu SYTL4 Interaktionspartnern

Human Synaptotagmin-Like 4 (SYTL4) Interaktionspartner

  1. Granuphilin makes granules immobile and fusion-reluctant beneath the plasma membrane. Those granuphilin-positive, docked granules release a portion of granuphilin upon fusion, and fuse at a frequency and time course similar to those of granuphilin-negative undocked granules. Granuphilin forms a 180-nm cluster at the site of each docked granule, along with granuphilin-interacting Rab27a (zeige RAB27A Proteine) and Munc18-1 (zeige STXBP1 Proteine) clusters.

  2. GLUT5 required an interaction cascade of Rab11 (zeige RAB11A Proteine), Myo5B, Slp4a, Munc18-2 (zeige STXBP2 Proteine), and Vamp7 (zeige VAMP7 Proteine) with Stx3 (zeige STX3 Proteine).

  3. Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis.

  4. the mechanisms of granuphilin plasma membrane targeting and release

  5. Recruitment of STXBP1 (zeige STXBP1 Proteine) by the Rab27A (zeige RAB27A Proteine) effector SYTL4 promotes Weibel-Palade body exocytosis.

  6. Slp4 (zeige S1PR4 Proteine) and Rab8 (zeige RAB8A Proteine) are expressed and interact in human platelets, and might be involved in dense granule release.

  7. in insulin (zeige INS Proteine)-producing cells adequate levels of mir (zeige MLXIP Proteine)-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity

  8. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (zeige SEPT9 Proteine) homology domain (SHD (zeige SHD Proteine)) (PMID: 11327731). The SHD (zeige SHD Proteine) of Slp4 (zeige S1PR4 Proteine) specifically and directly binds the GTP (zeige AK3 Proteine)-bound form of Rab3A (zeige RAB3A Proteine), Rab8 (zeige RAB8A Proteine), and Rab27A (zeige RAB27A Proteine).

Mouse (Murine) Synaptotagmin-Like 4 (SYTL4) Interaktionspartner

  1. Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.

  2. granuphilin binds to syntaxin-2 (zeige STX2 Proteine) and syntaxin-3 (zeige STX3 Proteine) as well as syntaxin-1a (zeige STX1A Proteine), it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane.

  3. granuphilin promotes the plasma membrane targeting of insulin (zeige INS Proteine) granules via interaction with syntaxin 1a (zeige STX1A Proteine)

  4. It is shown that the granuphilin promoter is a target of SREBP-1c (zeige SREBF1 Proteine), a transcription factor that controls fatty acid synthesis, and MafA (zeige MAFA Proteine), a beta (zeige SUCLA2 Proteine) cell differentiation factor

  5. Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp (zeige SEPT9 Proteine) homology domain (SHD (zeige SHD Proteine)) (PMID: 11327731). The SHD (zeige SHD Proteine) of Slp4 specifically and directly binds the GTP (zeige AK3 Proteine)-bound form of Rab3A (zeige RAB3A Proteine), Rab8 (zeige RAB8A Proteine), and Rab27A (zeige RAB27A Proteine).

SYTL4 Protein Überblick

Protein Überblick

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with SYTL4

  • synaptotagmin-like 4 (granuphilin-a) (SYTL4)
  • synaptotagmin-like 4 (sytl4)
  • synaptotagmin-like 4 (SYTL4)
  • synaptotagmin-like 4 (Sytl4)
  • Gph Protein
  • Slp4 Protein

Bezeichner auf Proteinebene für Synaptotagmin-Like 4 Proteine (SYTL4)

synaptotagmin-like 4 (granuphilin-a) , synaptotagmin-like 4 , exophilin-2 , granuphilin-a , synaptotagmin-like protein 4 , granuphilin , granuphilin-b , granuphilin b

GENE ID SPEZIES
422260 Gallus gallus
446280 Xenopus laevis
100023319 Monodelphis domestica
100057306 Equus caballus
100155912 Sus scrofa
100539153 Meleagris gallopavo
100589791 Nomascus leucogenys
94121 Homo sapiens
27359 Mus musculus
140594 Rattus norvegicus
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