Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteine (KCNJ11)

Bezeichnung:
Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteine (KCNJ11)
Auf www.antikoerper-online.de finden Sie aktuell 6 Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Antikörper (146) und Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 163 Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Produkte verfügbar.
Synonyme:
BIR, HHF2, IKATP, KIR6.2, mBIR, PHHI, TNDM3
alle Proteine anzeigen Gen GeneID UniProt
KCNJ11 16514 Q61743
Ratte KCNJ11 KCNJ11 83535 P70673
KCNJ11 3767 Q14654

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Weitere Proteine zu Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Interaktionspartnern

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Interaktionspartner

  1. ATP-sensitive K(+) Kir6.2 channels may play a novel role in regulating myocardial energy metabolism.

  2. Cardiac ischemia causes a loss of the sarcolemmal KATP channel density by internalization through a pathway mediated by dynamin (zeige DNM1 Proteine)-dependent endocytosis and CaMKII (zeige CAMK2G Proteine)-mediated signaling. Ischemic preconditioning counteracts thiscloss and restores the density of the sarcolemmal KATP channels.

  3. Lack of kcnj11 expression increases peroxynitrite-mediated modification of the key calcium-handling protein sarcoendoplasmic reticulum Ca(2+)-ATPase after myocardial ischemia-reperfusion injury, contributing to impaired diastolic function.

  4. K(ATP) channels seem to play an essential role in murine myometrial motility via activation of SUR2B (zeige ABCC9 Proteine) and Kir6.2

  5. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

  6. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 (zeige ABCC9 Proteine) variant

  7. The Kir6.2-containing K-ATP channel is required for cardioprotection of resveratrol.

  8. Report mechanical dyssynchrony as an early marker of cardiomyopathic disease in ATP-sensitive K channel (zeige KCNC4 Proteine)-deficient dilated cardiomyopathy.

  9. a role of K(ATP)-channel-dependent neuronal excitability in catecholaminergic neurons in maintaining thermogenic BAT (zeige BAAT Proteine) sympathetic tone and energy homeostasis.

  10. Data indicate that betaIV-Spectrin-targeted CaMKII (zeige CAMK2G Proteine) directly phosphorylates the inwardly-rectifying potassium channel (zeige KCNAB2 Proteine), Kir6.2.

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Interaktionspartner

  1. KCNJ11 mutation causing loss of function of beta-cell KATP channels lead to congenital hyperinsulinism, higher basal [Ca(2+)] i and insulin secretion, increased insulin secretion in response to amino acids but not to glucose, increased basal rate of oxygen consumption and mitochondrial mass, increased rates of glycolysis, increased serine/glycine and glutamine biosynthesis, and low gamma-aminobutyric acid (GABA) levels.

  2. Functional studies indicated that the Kir6.2-G324R mutation reduces the channel ATP sensitivity but that the difference in ATP inhibition between homozygous and heterozygous channels is remarkably small. Nevertheless, the homozygous patient developed neonatal diabetes, whereas the heterozygous parents were, and remain, unaffected.

  3. KCNJ11 expression is decreased in human ischemia cardiomyopathy.

  4. KCNJ11 mutation is associated with permanent neonatal diabetes mellitus.

  5. The polymorphic marker Glu23Lys in the KCNJ11 gene is associated with hypertension in Kyrgyzia.

  6. Cross-linking experiments showed that KATP channel inhibitors promoted interactions between the N terminus of Kir6.2 and SUR1, whereas channel openers did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis and trafficking defects.

  7. The genotype (EE/EK/KK) frequencies (%) for the CTRL group (38.2/50.2/11.6), Type 1 Diabetes (34.3/52.0/13.7), and Type 2 Diabetes (38.2/48.9/12.9) were in Hardy-Weinberg equilibrium and there were no significant differences. The minor allele frequencies (MAF; K) for CTRL (37.0%), Type 1 Diabetes (39.7%), and Type 2 Diabetes (37.4%) were not different among the groups

  8. KCNJ11 mutation is associated with permanent neonatal diabetes.

  9. A male infant who was diagnosed with congenital hyperinsulinism (CHI) with a novel homozygous p.F315I mutation in the kcnj11 channel (KCNJ11) gene, and parents were second cousins both with heterozygous mutations for this gene, and the patient was successfully managed with sirolimus therapy.

  10. The most frequently seen mutations in Turkish patients with congenital hyperinsulinism (CHI) were ATP binding cassette subfamily C member 8 (ABCC8 (zeige ABCC8 Proteine)) gene, followed by 3-hydroxyacyl CoA dehydrogenase (HADH (zeige HADH Proteine)) and kcnj11 channel (KCNJ11) genes.

Rabbit Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Interaktionspartner

  1. Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 (zeige KCNJ8 Proteine) and SUR2B (zeige ABCC9 Proteine) subtypes are reduced in left ventricular hypertrophy models.

Pig (Porcine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Interaktionspartner

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1 (zeige ABCC8 Proteine)), inward rectifying potassium channel (zeige KCNAB2 Proteine) (Kir6.2, associated with Sur1 (zeige ABCC8 Proteine)), glucagon-like peptide 1 receptor (GLP1R (zeige GLP1R Proteine)), and adrenergic receptor alpha 2A (zeige ADRA2A Proteine) (ADRalpha2A)

  2. The predominant K(ATP) channel expressed in pig urethral smooth muscle possesses a unique, heteromeric pore structure with a pore-forming subunit composition of (Kir6.1 (zeige KCNJ8 Proteine))(3)-(Kir6.2).

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Protein Überblick

Protein Überblick

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Alternative names and synonyms associated with Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11)

  • potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11)
  • potassium inwardly-rectifying channel, subfamily J, member 11 (kcnj11)
  • potassium inwardly rectifying channel, subfamily J, member 11 (Kcnj11)
  • BIR Protein
  • HHF2 Protein
  • IKATP Protein
  • KIR6.2 Protein
  • mBIR Protein
  • PHHI Protein
  • TNDM3 Protein

Bezeichner auf Proteinebene für KCNJ11

potassium inwardly-rectifying channel, subfamily J, member 11 , potassium inwardly-rectifying channel J11 , ATP-sensitive inward rectifier potassium channel 11 , ATP-sensitive inward rectifier potassium channel 11-like , inward rectifier K(+) channel Kir6.2 , BIR , potassium channel, inwardly rectifying subfamily J member 11 , potassium inwardly-rectifying channel subfamily J member 11 , IKATP , inward rectifier potassium channel Kir6.2 , beta-cell inward rectifier subunit , inwardly rectifying potassium channel KIR6.2 , potassium channel inwardly rectifing subfamily J member 11 , potassium inwardly rectifying channel, subfamily J, member 11 , ATP-sensitive inward rectifier potassium channel Kir6.2 , inwardly rectifying potassium channel Kir6.2

GENE ID SPEZIES
428846 Gallus gallus
466450 Pan troglodytes
664687 Danio rerio
100401039 Callithrix jacchus
100456411 Pongo abelii
16514 Mus musculus
83535 Rattus norvegicus
100135564 Cavia porcellus
3767 Homo sapiens
485401 Canis lupus familiaris
100008648 Oryctolagus cuniculus
100158240 Sus scrofa
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