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On normal salt diet, renal CuZnSOD (zeige SOD1 ELISA Kits) and ECSOD (zeige SOD3 ELISA Kits) proteins were similar but renal MnSOD (zeige SOD2 ELISA Kits) was lower in hGRK4g486V than Non-T mice and remained low on high salt diet. hGRK4gammawild-type mice were normotensive and hGRK4g142V mice were hypertensive but both were salt-resistant and in normal redox balance. Chronic tempol treatment partially prevented the salt-sensitivity of hGRK4g486V mice.
A novel function of GRK4 on triggering a p53 (zeige TP53 ELISA Kits)-independent cellular senescence, which involves an intricate signaling network.
the association between GRK4(142V) and a larger decrease in blood pressure with angiotensin receptor blockers in hypertensive patients.
Subgroup analysis for ethnicity showed that rs1024323 locus of GRK4 gene was associated with hypertension in Caucasians (OR =1.826, 95% CI =1.215-2.745, P=0.004) but not in East Asians and Africans. [meta-analysis]
Thus, we provided new insight into the function of GRKs in agonist-unstimulated GPCR (zeige NMUR1 ELISA Kits) trafficking using a recombinant AM1 receptor and further determined the region of the CLR C (zeige CLEC2G ELISA Kits)-tail responsible for this GRK function.
hGRK4gamma(142V) phosphorylates histone deacetylase (zeige HDAC1 ELISA Kits) type 1 and promotes its nuclear export to the cytoplasm, resulting in increased AT1R (zeige AGTR1 ELISA Kits) expression and greater pressor response to angiotensin II.
A high sodium intake markedly increased the obesity risk in variants of GRK4 A486V regardless of sex amongst Korean children.
The C-terminal region of FMRP (zeige FMR1 ELISA Kits) interacts with a domain of GRK4 mRNA that is folded in four stem loops.
GRK4alpha is more similar to GRK2 (zeige ADRBK1 ELISA Kits) than GRK6 (zeige GRK6 ELISA Kits). A fully ordered kinase C-tail reveals interactions linking the C-tail with important determinants of kinase activity, including the alphaB helix, alphaD helix, and the P-loop
GRK4 genetic polymorphism plays an important role in the regulation of hypertension.
The role of GRK2 (zeige ADRBK1 ELISA Kits) in chronic ET-1 (zeige EDN1 ELISA Kits)-induced insulin (zeige INS ELISA Kits) resistance was investigated.
GRK2 (zeige ADRBK1 ELISA Kits) inhibits WNT (zeige WNT2 ELISA Kits) signaling in osteoblasts
AMPK can function outside of its canonical nutrient-sensing role in specific developmental contexts.
The significance of these findings is that AMPK is important in the regulation of glucagon (zeige GCG ELISA Kits) signaling, suggesting that the organization of metabolic networks is highly conserved and that AMPK plays a prominent role in these networks.
Loss of AMPK activity exacerbates neuronal loss and associated phenotypes in parkin (zeige PARK2 ELISA Kits) and LRRK transgenic flies.
Data suggest that that an Sgt1 (zeige SUGT1 ELISA Kits)/Hsp90 (zeige HSP90 ELISA Kits)-LKB1 (zeige STK11 ELISA Kits)-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors.
AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.
AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut (zeige GUSB ELISA Kits)
These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance.
activated by AMP (zeige AMPH ELISA Kits) in cell-free assays and by stresses that deplete ATP; the phosphorylated DmAMPK alpha subunit (zeige POLG ELISA Kits) was mainly detected in the nucleus
results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures
LKB1 (zeige STK11 ELISA Kits) and AMPK have roles in cell polarity and division [review]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.
, G protein-coupled receptor kinase 2, groucho gene related
, g protein-coupled receptor kinase GRK4
, 5'monophosphate-activated kinase
, AMP-activated kinase
, AMP-activated protein kinase
, AMP-dependent kinase
, G protein-coupled receptor kinase 4
, SNF/AMP-activated protein S/T kinase gamma subunit
, adenosine monophosphate-activated protein kinase
, G-protein-coupled receptor kinase 2-like