GNB1 Proteine (GNB1)

Bezeichnung:
Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 Proteine (GNB1)
Auf www.antikoerper-online.de finden Sie aktuell 4 Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen GNB1 Antikörper (61) und GNB1 Kits (30) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 100 GNB1 Produkte verfügbar.
Synonyme:
AA409223, C77571, Gnb-1, XGB1, xgbeta1
alle Proteine anzeigen Gen GeneID UniProt
GNB1 14688 P62874
GNB1 2782 P62873
Ratte GNB1 GNB1 24400 P54311

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Weitere Proteine zu GNB1 Interaktionspartnern

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1) Interaktionspartner

  1. Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca (zeige PPP1CA Proteine) and Gnb1 interact in quiescent platelets; then, Ppp1ca (zeige PPP1CA Proteine) and Plcb3 (zeige PLCB3 Proteine) interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca (zeige PPP1CA Proteine) to modulate G protein-coupled receptor (zeige GPR34 Proteine) signaling. (Ppp1ca (zeige PPP1CA Proteine) = protein phosphatase 1 (zeige PPP1CB Proteine), catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein (zeige TRIM23 Proteine), subunit beta-1; Plcb3 (zeige PLCB3 Proteine) = phospholipase C (zeige PLC Proteine), subunit beta-3)

  2. It was concluded that GIRK2 (zeige KCNJ6 Proteine), through its dual responsiveness to G protein beta (zeige GNB3 Proteine)-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.

  3. During corticogenesis, a cilium-transduced, noncanonical IGF-1R (zeige IGF1R Proteine)-Gbetagamma-phospho(T94)Tctex-1 (zeige DYNLT1 Proteine) signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

  4. ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin

  5. Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o (zeige GNAO1 Proteine)) upon activation of mGluR6 (zeige GRM6 Proteine) closes the TRPM1 (zeige TRPM1 Proteine) channel, perhaps via a direct interaction.

  6. WDR26 (zeige WDR26 Proteine) is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration

  7. Our data suggest that the G-protein beta(1)gamma(2) dimer may play an important regulatory role in skeletal muscle excitation-contraction coupling.

  8. G protein subunits beta1 and beta2 have different roles in neutrophil function, as revealed by gene expression silencing in primary mouse neutrophils

  9. G betagamma binds HDAC5 (zeige HDAC5 Proteine) and inhibits its transcriptional co-repression activity

  10. G protein betagamma subunits stimulate type V and VI adenylyl cyclases

Human Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1) Interaktionspartner

  1. Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures.

  2. we demonstrate a pathogenic role of de novo and autosomal dominant mutations in GNB1 as a cause of Global developmental delay and provide insights how perturbation in heterotrimeric G protein function contributes to the disease

  3. PhLP1 binding stabilizes the Gbeta (zeige SUCLG2 Proteine) fold, disrupting interactions with CCT (zeige FLVCR2 Proteine) and releasing a PhLP1-Gbeta (zeige SUCLG2 Proteine) dimer for assembly with Ggamma.

  4. GNB1 and GNB2 alterations confer transformed and resistance phenotypes across a range of human tumors and may be targetable with inhibitors of G protein signaling.

  5. Data indicate that endogenous mTOR (zeige FRAP1 Proteine) interacts with Gbetagamma.

  6. During corticogenesis, a cilium-transduced, noncanonical IGF-1R (zeige IGF1R Proteine)-Gbetagamma-phospho(T94)Tctex-1 (zeige DYNLT1 Proteine) signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.

  7. GNB1 plays an important role in the mTOR (zeige FRAP1 Proteine)-related anti-apoptosis pathway and can potentially be targeted in the treatment of human breast cancer.

  8. Findings suggest a wide-ranging mechanism by which direct interaction of Gbetagamma with specific chromatin bound transcription factors regulates functional gene networks in response to GPCR (zeige NMUR1 Proteine) activation in cells including the angiotensin II type 1 receptor (zeige AGTR1 Proteine).

  9. This study provided evidence that GNB1 gene polymorphisms are related to rapid virological response in HCV-1 and HCV-2 (zeige BMPER Proteine) infected patients. GNB1 may play an important role in activating the antiviral response prior to treatment.

  10. WDR26 (zeige WDR26 Proteine) is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration

Xenopus laevis Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1) Interaktionspartner

  1. Gbeta1gamma2-mediated epithelial sodium channel (ENaC) inhibition involves activation of phospholipase C-beta and its enzymatic products that induce protein kinase C and ERK1/2 signaling pathways.

Cow (Bovine) Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1 (GNB1) Interaktionspartner

  1. Data suggest that a hetero-multimer complex forms between light-activated rhodopsin and light-activated heterotrimeric transducin (zeige GNAT1 Proteine) (T-alpha-1, Gnb1, Gngt1 (zeige GNGT1 Proteine)); the stoichiometry is 1:1 rhodopsin:transducin. The complex appears to form on native rod outer segment membranes upon light activation.

  2. The PIP2-induced orientation of the GRK2 (zeige ADRBK1 Proteine)-Gbeta1gamma2 complex is therefore most likely caused by specific interactions between PIP2 and the GRK2 (zeige ADRBK1 Proteine) PH domain.

  3. determined the crystallographic structure of GRK2 in complex with G protein beta1gamma2 subunits

  4. conclude that GNB1 constitutes over 99% of the GNbeta expressed in bovine rod outer segments and displays structural heterogeneity that is due to post-translational modification, some of which is due to phosphorylation of GNB1.

GNB1 Protein Überblick

Protein Überblick

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

Alternative names and synonyms associated with GNB1

  • guanine nucleotide binding protein (G protein), beta 1 (Gnb1)
  • guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1)
  • guanine nucleotide binding protein (G protein), beta polypeptide 1 (Gnb1)
  • guanine nucleotide binding protein (G protein), beta polypeptide 1 (gnb1)
  • AA409223 Protein
  • C77571 Protein
  • Gnb-1 Protein
  • XGB1 Protein
  • xgbeta1 Protein

Bezeichner auf Proteinebene für GNB1

guanine nucleotide binding protein, beta 1 , guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 , transducin beta chain 1 , G protein, beta-1 subunit , beta subunit, signal-transducing proteins GS/GI , guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1 , Guanine nucleotide-binding protein beta 1 , guanine nucleotide binding protein (G protein), beta 1 , guanine nucleotide-binding protein, beta-1 subunit , rod transducin , beta 1 subunit of heterotrimeric GTP-binding protein

GENE ID SPEZIES
14688 Mus musculus
2782 Homo sapiens
24400 Rattus norvegicus
403912 Canis lupus familiaris
399330 Xenopus laevis
281201 Bos taurus
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