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Atp2a2/serca2 is found in a larger subset of cells, but is not ubiquitous as reported in adults.
the genomic organization and the equine ATP2A2 coding sequence and an association analysis for chronic pastern dermatitis using a sample of South German draft horses
Taken together, these results suggest that SERCA2 contributes to the migration of CCL21 (zeige CCL21 ELISA Kits)-activated Dendritic Cells as an important feature of the adaptive immune response and provide novel insights regarding the role of SERCA2 in Dendritic Cells functions.
VMP1 (zeige VMP1 ELISA Kits) modulates SERCA2 activity to control endoplasmic reticulum contacts for autophagosome formation.
The left atrium / right atrium expression ratio was significantly increased in Atrial fibrillation for SERCA2 - gene related to calcium uptake and release, and located on the sarcoplasmic reticulum membrane.
Loss of SERCA2 impairs ER-to-Golgi transport of nascent DC.
We propose that the increased SERCA1a (zeige ATP2A1 ELISA Kits) expression indicates the existence and location of compensating mechanisms in ischemic muscle.
Results show that ATP2A2 is variably expressed in astrocytoma tissues and its expression correlates with tumor grade. Its overexpression suppresses growth of astrocytoma cells.
study identifies a novel splice acceptor site mutation in the ATP2A2 gene, in a family showing Darier disease
Data suggest that mutations of the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) gene may lead to the occurrence of Darier disease (DD) in both familial and sporadic cases with DD.
Phospholamban (zeige PLN ELISA Kits) and sarcolipin (zeige SLN ELISA Kits) are membrane proteins that differentially regulate SERCA (zeige ATP2A3 ELISA Kits) function. (Review)
CAPN3 (zeige CAPN3 ELISA Kits) deficiency leads to degradation of SERCA (zeige ATP2A3 ELISA Kits) proteins and Ca2 (zeige CA2 ELISA Kits)+ dysregulation in the skeletal muscle.
Data suggest that the beneficial effects of SERCA2a gene transfer may involve the attenuation of ER stress-associated myocardial apoptosis.
Oxidative/nitrosative stress associated with lung resection influences SERCA2a activity independent of any influence on protein expression or phospholamban (zeige PLN ELISA Kits) phosphorylation.
overexpression of SERCA2a by in vivo rAAV1-mediated intracoronary gene transfer preserved systolic function, potentially prevented diastolic dysfunction, and improved ventricular remodeling.
Data show that rabbit cold tolerance is probably related to increased muscle oxidative metabolism and heat production by SERCA1 (zeige ATP2A1 ELISA Kits) and that these changes are not completely dependent on normal thyroid function.
These results indicate a mechanism relating SERCA1 (zeige ATP2A1 ELISA Kits) vicinal-cysteines oxidation to muscle fatigue.
Nevertheless, the functional role of protein serotonylation in controlling SAN automaticity is largely unexplored. In this study, we screened the cardiomyocytes proteins and found that sarco(endo)plasmic reticulum Ca ATPase (zeige CA-P60A ELISA Kits) type 2a (SERCA2a) can be serotonylated. Simulation studies using mathematical SAN cell model showed that variation of Ca(2 (zeige CA2 ELISA Kits)+) affinity of SERCA2a pump cause either tachycardia or bradycardia.
Muscle RANK deletion had no significant effects on the sham or denervated slow-twitch soleus muscles. These data identify a novel role for RANK as a key regulator of Ca(2 (zeige CA2 ELISA Kits)+)storage and SERCA (zeige ATP2A3 ELISA Kits) activity, ultimately affecting denervated skeletal muscle function.
Generated were mice harboring N-ethyl-N-nitrosourea (ENU)-induced allelic mutations in Serca2: three missense mutations and one nonsense mutation. Mice harboring these Serca2 mutations developed tumors that were categorized as either early onset squamous cell tumors (SCT), with development similar to null-type knockout mice [2,4] (aggressive form; M682, M814), or late onset tumors (mild form; M1049, M1162).
Identify Atrap (zeige AGTRAP ELISA Kits) as a novel regulatory protein (zeige TGFB1 ELISA Kits) of the cardiac Ca(2+)-ATPase SERCA2a (zeige CA-P60A ELISA Kits). Suggest that Atrap (zeige AGTRAP ELISA Kits) enhances the activity of SERCA2a and, consequently, facilitates ventricular relaxation.
Sustained activation of Toll-like receptor 9 (zeige TLR9 ELISA Kits) causes cardiac and systemic inflammation, and deterioration of SERCA2a depletion-mediated diastolic heart failure.
The LRP1 (zeige LRP1 ELISA Kits)/Pyk2 (zeige PTK2B ELISA Kits) axis represses SERCA2 mRNA expression via HIF-1a (zeige HIF1A ELISA Kits).
This first-in-class small-molecule activator targeting SERCA2a SUMOylation may serve as a potential therapeutic strategy for treatment of heart failure
privileged signal communication between the beta1-adrenergic receptor and SERCA2a impaired in cardiac hypertrophy
SERCA2a gene transfer in the failing heart not only improves contractile function but also directly restores electric stability through amelioration of key arrhythmogenic substrate.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Calcium ATPase at 60A
, ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
, sarcoplasmic/endoplasmic reticulum calcium ATPase 2
, sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like
, ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2
, SR Ca(2+)-ATPase 2
, calcium pump 2
, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
, cardiac Ca2+ ATPase
, endoplasmic reticulum class 1/2 Ca(2+) ATPase
, calcium ATPase
, sarcoplasmic reticulum Ca2+-transport ATPase isoform
, Ca(2+)-transport ATPase class 3
, sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2
, ATPase, Ca++ transporting, slow twitch 2
, sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2
, sarco/endoplasmic reticulum Ca2+-ATPase 2
, sarcoplasmic reticulum slow-twitch Ca2 ATPase